Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Jana Holubova"'
Autor:
Anna Lepesheva, Adriana Osickova, Jana Holubova, David Jurnecka, Sarka Knoblochova, Carlos Espinosa-Vinals, Ladislav Bumba, Karolina Skopova, Radovan Fiser, Radim Osicka, Peter Sebo, Jiri Masin
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Pore-forming repeats in toxins (RTX) are key virulence factors of many Gram-negative pathogens. We have recently shown that the aromatic side chain of the conserved tyrosine residue 940 within the acylated segment of the RTX adenylate cyclas
Externí odkaz:
https://doaj.org/article/6f873568b2e4490a9da5948d8fb80b36
Autor:
Nela Klimova, Jana Holubova, Gaia Streparola, Jakub Tomala, Ludmila Brazdilova, Ondrej Stanek, Ladislav Bumba, Peter Sebo
Publikováno v:
PLoS Pathogens, Vol 18, Iss 6, p e1010577 (2022)
The adenylate cyclase (ACT) and the pertussis (PT) toxins of Bordetella pertussis exert potent immunomodulatory activities that synergize to suppress host defense in the course of whooping cough pathogenesis. We compared the mouse lung infection capa
Externí odkaz:
https://doaj.org/article/881f5b46d1f04874b1279ed1b9cd2ffd
Autor:
Jana Holubova, Ondrej Stanek, Attila Juhasz, Illiassou Hamidou Soumana, Peter Makovicky, Peter Sebo
Publikováno v:
PLoS Pathogens, Vol 18, Iss 4, p e1010402 (2022)
Pulmonary infections caused by Bordetella pertussis used to be the prime cause of infant mortality in the pre-vaccine era and mouse models of pertussis pneumonia served in characterization of B. pertussis virulence mechanisms. However, the biological
Externí odkaz:
https://doaj.org/article/5061be2846c0463c8a747164e5321cd1
Autor:
Maryam Golshani, Waheed Ur Rahman, Adriana Osickova, Jana Holubova, Jinery Lora, Nataliya Balashova, Peter Sebo, Radim Osicka
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 20, p 12598 (2022)
The pertussis agent Bordetella pertussis produces a number of virulence factors, of which the filamentous hemagglutinin (FhaB) plays a role in B. pertussis adhesion to epithelial and phagocytic cells. Moreover, FhaB was recently found to play a cruci
Externí odkaz:
https://doaj.org/article/e23a5aa7fd7d40388b6390cfea172099
Autor:
Jan Bayram, Ivana Malcova, Larisa Sinkovec, Jana Holubova, Gaia Streparola, David Jurnecka, Jan Kucera, Radislav Sedlacek, Peter Sebo, Jana Kamanova
Publikováno v:
PLoS Pathogens, Vol 16, Iss 8, p e1008512 (2020)
Bordetella bronchiseptica and Bordetella pertussis are closely related respiratory pathogens that evolved from a common bacterial ancestor. While B. bronchiseptica has an environmental reservoir and mostly establishes chronic infections in a broad ra
Externí odkaz:
https://doaj.org/article/609338df51f94ddb8a7a6e9190e83304
Autor:
Jawid Nazir Ahmad, Jana Holubova, Oldrich Benada, Olga Kofronova, Ludek Stehlik, Martina Vasakova, Peter Sebo
Publikováno v:
mBio, Vol 10, Iss 5 (2019)
ABSTRACT Monocytes arriving at the site of infection differentiate into functional effector macrophages to replenish the resident sentinel cells. Bordetella pertussis, the pertussis agent, secretes an adenylate cyclase toxin-hemolysin (CyaA) that bin
Externí odkaz:
https://doaj.org/article/0e10c91101794d2cb60859cedefcfb04
Autor:
Jana Holubova, Attila Juhasz, Jiri Masin, Ondrej Stanek, David Jurnecka, Adriana Osickova, Peter Sebo, Radim Osicka
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11655 (2021)
The whooping cough agent, Bordetella pertussis, secretes an adenylate cyclase toxin–hemolysin (CyaA, ACT, or AC-Hly) that catalyzes the conversion of intracellular ATP to cAMP and through its signaling annihilates the bactericidal activities of hos
Externí odkaz:
https://doaj.org/article/0803fecdd7814728ba5514a977f1ed41
Autor:
Anna Malandra, Waheed Ur Rahman, Nela Klimova, Gaia Streparola, Jana Holubova, Adriana Osickova, Simone Bariselli, Peter Sebo, Radim Osicka
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 16, p 9064 (2021)
The mucus layer protects airway epithelia from damage by noxious agents. Intriguingly, Bordetella pertussis bacteria provoke massive mucus production by nasopharyngeal epithelia during the initial coryza-like catarrhal stage of human pertussis and th
Externí odkaz:
https://doaj.org/article/c8c7de1cdf384ae88be2fb1d02340f98
Autor:
Ondrej Stanek, Irena Linhartova, Jana Holubova, Ladislav Bumba, Zdenko Gardian, Anna Malandra, Barbora Bockova, Shihono Teruya, Yasuhiko Horiguchi, Radim Osicka, Peter Sebo
Publikováno v:
Toxins, Vol 12, Iss 9, p 596 (2020)
Pathogenic Bordetella bacteria release a neurotropic dermonecrotic toxin (DNT) that is endocytosed into animal cells and permanently activates the Rho family GTPases by polyamination or deamidation of the glutamine residues in their switch II regions
Externí odkaz:
https://doaj.org/article/98ac1536e9904eb0a2b2fcb22602eb9c
Autor:
Maryam, Golshani, Waheed Ur, Rahman, Adriana, Osickova, Jana, Holubova, Jinery, Lora, Nataliya, Balashova, Peter, Sebo, Radim, Osicka
Publikováno v:
International journal of molecular sciences. 23(20)
The pertussis agent