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Akademický článek

Overexpression of KMT9α Is Associated with Aggressive Basal-like Muscle-Invasive Bladder Cancer

Autor: Florestan J. Koll, Eric Metzger, Jana Hamann, Anna Ramos-Triguero, Katrin Bankov, Jens Köllermann, Claudia Döring, Felix K. H. Chun, Roland Schüle, Peter J. Wild, Henning Reis

Publikováno v: Cells, Vol 12, Iss 4, p 589 (2023)

Muscle-invasive bladder cancer (MIBC) is associated with limited response rates to systemic therapy leading to a significant risk of recurrence and death. A recently discovered histone methyltransferase KMT9, acts as an epigenetic regulator of carcin

Externí odkaz: https://doaj.org/article/d2a64b8c2f5c434597a6c170c69b9018

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Akademický článek

RHAMM deficiency disrupts folliculogenesis resulting in female hypofertility

Autor: Huaibiao Li, Jürgen Moll, Anne Winkler, Lucien Frappart, Stéphane Brunet, Jana Hamann, Torsten Kroll, Marie-Hélène Verlhac, Heike Heuer, Peter Herrlich, Aspasia Ploubidou

Publikováno v: Biology Open, Vol 4, Iss 4, Pp 562-571 (2015)

The postnatal mammalian ovary contains the primary follicles, each comprising an immature oocyte surrounded by a layer of somatic granulosa cells. Oocytes reach meiotic and developmental competence via folliculogenesis. During this process, the granu

Externí odkaz: https://doaj.org/article/c52a9e8199fd4e998666121f62aaf41c

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Supplemental Materials & Methods from Impaired Planar Germ Cell Division in the Testis, Caused by Dissociation of RHAMM from the Spindle, Results in Hypofertility and Seminoma

Autor: Aspasia Ploubidou, Peter Herrlich, Kurt Zatloukal, Matthias Platzer, Bodo M.H. Lange, Heike Heuer, Marie-Laure Yaspo, Moritz Schütte, Stefan Taudien, Marco Groth, Iris Kufferath, Jana Hamann, Torsten Kroll, Anne Winkler, Jürgen Moll, Lucien Frappart, Huaibiao Li

Supplemental Materials & Methods and the references cited within.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72944a0c1595afe168fbee203c75e09b
https://doi.org/10.1158/0008-5472.22413344.v1

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Supplemental Figure Legends from Impaired Planar Germ Cell Division in the Testis, Caused by Dissociation of RHAMM from the Spindle, Results in Hypofertility and Seminoma

Legends of supplemental figures S1-S5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06cde4536f977a80ac0e85a6a8717a95
https://doi.org/10.1158/0008-5472.22413368.v1

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Supplemental Table S1 from Impaired Planar Germ Cell Division in the Testis, Caused by Dissociation of RHAMM from the Spindle, Results in Hypofertility and Seminoma

Overview of human testis biopsy samples, which were analyzed for RHAMM parameters (mRNA expression, protein localization, locus variants, allele frequencies) as well as for expression of CFIm25 and of 12 TGCT susceptibility genes.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5df88b6581e45b7edd6ec3bb17e32b8b
https://doi.org/10.1158/0008-5472.22413341.v1

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Supplemental Figure S1 from Impaired Planar Germ Cell Division in the Testis, Caused by Dissociation of RHAMM from the Spindle, Results in Hypofertility and Seminoma

Its centrosome-targeting domain is indispensable for RHAMM spindle localization and it contributes to maintenance of spindle integrity in vitro.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::008bbccae308631fac120dacdcaf1198
https://doi.org/10.1158/0008-5472.22413362

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Data from Impaired Planar Germ Cell Division in the Testis, Caused by Dissociation of RHAMM from the Spindle, Results in Hypofertility and Seminoma

Hypofertility is a risk factor for the development of testicular germ cell tumors (TGCT), but the initiating event linking these pathologies is unknown. We hypothesized that excessive planar division of undifferentiated germ cells promotes their self

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a2720ac810fb206ff8fdc28e3e6034c9
https://doi.org/10.1158/0008-5472.c.6508691.v1

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Impaired Planar Germ Cell Division in the Testis, Caused by Dissociation of RHAMM from the Spindle, Results in Hypofertility and Seminoma

Autor: Anne Winkler, Marco Groth, Moritz Schütte, Stefan Taudien, Aspasia Ploubidou, Jürgen Moll, Iris Kufferath, Kurt Zatloukal, Peter Herrlich, Huaibiao Li, Heike Heuer, Lucien Frappart, Torsten Kroll, Marie-Laure Yaspo, Matthias Platzer, Bodo Lange, Jana Hamann

Publikováno v: Cancer research : an official organ of the American Association for Cancer Research

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d07ce740fc68b8a0840ed48b3c5e55c0
https://doi.org/10.1158/0008-5472.can-16-0179

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High-Content Microscopy Analysis of Subcellular Structures: Assay Development and Application to Focal Adhesion Quantification

Autor: Torsten, Kroll, David, Schmidt, Georg, Schwanitz, Mubashir, Ahmad, Jana, Hamann, Corinne, Schlosser, Yu-Chieh, Lin, Konrad J, Böhm, Jan, Tuckermann, Aspasia, Ploubidou

Publikováno v: Current protocols in cytometryLiterature Cited. 77

High-content analysis (HCA) converts raw light microscopy images to quantitative data through the automated extraction, multiparametric analysis, and classification of the relevant information content. Combined with automated high-throughput image ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ba6cb7b476c725bd0dadf6157eff16a6
https://pubmed.ncbi.nlm.nih.gov/27367288

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RHAMM deficiency disrupts folliculogenesis resulting in female hypofertility

Autor: Anne Winkler, Heike Heuer, Jürgen Moll, Huaibiao Li, Peter Herrlich, Aspasia Ploubidou, Lucien Frappart, Stéphane Brunet, Torsten Kroll, Marie-Hélène Verlhac, Jana Hamann

Publikováno v: Biology Open
Biology open, 4 (4), 562-571
Biology Open, Royal Society, 2015, 4 (4), pp.562-571. ⟨10.1242/bio.201410892⟩
Biology Open, Vol 4, Iss 4, Pp 562-571 (2015)
Biology open, 4(4): 562-571

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da8bec5b4612cd2dceb8644d92d43dcc
https://pubmed.ncbi.nlm.nih.gov/25750434

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