Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jana Gomez"'
Autor:
Jesus M. Duran Ramirez, Jana Gomez, Blake M. Hanson, Taha Isa, Terence M. Myckatyn, Jennifer N. Walker
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 1 (2023)
ABSTRACT Breast implant-associated infections (BIAIs) are the primary complication following placement of breast prostheses in breast cancer reconstruction. Given the prevalence of breast cancer, reconstructive failure due to infection results in sig
Externí odkaz:
https://doaj.org/article/44db0430232149a29ccad1416c1da08a
Autor:
Jesus M. Duran Ramirez, Jana Gomez, Chloe L. P. Obernuefemann, Nathaniel C. Gualberto, Jennifer N. Walker
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Catheter-associated urinary tract infections (CAUTIs) are one of the most common healthcare-associated infections in the US, accounting for over 1 million cases annually and totaling 450 million USD. CAUTIs have high morbidity and mortality rates and
Externí odkaz:
https://doaj.org/article/7f4fd995482b4477aba9ce1ff97cb8e5
Autor:
Jesus M. Duran Ramirez, Jana Gomez, Blake Hanson, Taha Isa, Terence Myckatyn, Jennifer N Walker
Breast implant-associated infections (BIAIs) are a common complication following breast prostheses placement and account for ∼100,000 infections annually. The frequency, high cost of treatment, and morbidity make BIAIs a significant health burden f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::172cd9b4f29328628d05b1a87d153c5f
https://doi.org/10.1101/2022.07.18.500563
https://doi.org/10.1101/2022.07.18.500563
Autor:
Jana Gomez, Jair L. Siqueira-Neto, Drake M. Mellott, Jorge Cruz-Reyes, Emily Desormeaux, Claudia Calvet Alvarez, Jean A. Bernatchez, Thomas D. Meek, Linfeng Li, Xiang Zhai, Elizabeth Alvarez Hernandez, Balachandra Chenna, James H. McKerrow
Publikováno v:
J Med Chem
Cruzain, an essential cysteine protease of the parasitic protozoan, Trypanosoma cruzi, is an important drug target for Chagas disease. We describe here a new series of reversible but time-dependent inhibitors of cruzain, composed of a dipeptide scaff
Autor:
Zachary T Goodall, Wenshe R. Liu, Miriam A. Giardini, Arthur Laganowsky, Claudia M. Calvet, Jiyun Zhu, Kai S Yang, Jana Gomez, Diane Thomas, Chien-Te K Tseng, Balachandra Chenna, A. Joshua Wand, Jair L. Siqueira-Neto, Linfeng Li, Aleksandra Drelich, Zahra Moghadamchargari, Jean A. Bernatchez, Lauren R Blankenship, Drake M. Mellott, Jorge Cruz-Reyes, Thomas D. Meek, Taylor R. Cole, Elizabeth Alvarez Hernandez, Andrew Rademacher
Publikováno v:
Journal of medicinal chemistry. 64(15)
Cysteine proteases comprise an important class of drug targets, especially for infectious diseases such as Chagas disease (cruzain) and COVID-19 (3CL protease, cathepsin L). Peptide aldehydes have proven to be potent inhibitors for all of these prote