Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jana Dobrovolna"'
Autor:
Andra S. Martinikova, Miroslav Stoyanov, Anna Oravetzova, Yannick P. Kok, Shibo Yu, Jana Dobrovolna, Pavel Janscak, Marcel vanVugt, Libor Macurek
Publikováno v:
Molecular Oncology, Vol 18, Iss 1, Pp 6-20 (2024)
Oncogene‐induced replication stress has been recognized as a major cause of genome instability in cancer cells. Increased expression of cyclin E1 caused by amplification of the CCNE1 gene is a common cause of replication stress in various cancers.
Externí odkaz:
https://doaj.org/article/bca8c70888bf4c5eb9181c8b76ab63bf
Autor:
Martin Andrs, Henriette Stoy, Barbora Boleslavska, Nagaraja Chappidi, Radhakrishnan Kanagaraj, Zuzana Nascakova, Shruti Menon, Satyajeet Rao, Anna Oravetzova, Jana Dobrovolna, Kalpana Surendranath, Massimo Lopes, Pavel Janscak
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Excessive oxidative stress is widely perceived as a key factor in cancer progression. Here, the authors reveal that oxidative stress induces transcription-dependent replication fork stalling that appears to be a major source of chromosomal rearrangem
Externí odkaz:
https://doaj.org/article/745c0a072ad8422ca874cba769fe660b
Autor:
Michael Bauer, Zuzana Nascakova, Anca-Irina Mihai, Phil F. Cheng, Mitchell P. Levesque, Simon Lampart, Robert Hurwitz, Lennart Pfannkuch, Jana Dobrovolna, Melanie Jacobs, Sina Bartfeld, Anders Dohlman, Xiling Shen, Alevtina A. Gall, Nina R. Salama, Antonia Töpfer, Achim Weber, Thomas F. Meyer, Pavel Janscak, Anne Müller
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The bacterial pathogen Helicobacter pylori is known for its ability to induce DNA double-strand breaks in the genome of its target cells. Here, we show that H. pylori-induced DNA damage and replication stress occurs in S-phase cells as a result of R-
Externí odkaz:
https://doaj.org/article/776595ded02849959ccfec289f6e8902
Autor:
Andra S. Martinikova, Miroslav Stoyanov, Anna Oravetzova, Yannick P. Kok, Shibo Yu, Jana Dobrovolna, Pavel Janscak, Marcel van Vugt, Libor Macurek
Publikováno v:
Molecular Oncology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::002d0e2bea494925e239a3b44e2c2e34
https://doi.org/10.1002/1878-0261.13433
https://doi.org/10.1002/1878-0261.13433
Autor:
null Andra S. Martinikova, null Miroslav Stoyanov, null Anna Oravetzova, null Yannick P. Kok, null Shibo Yu, null Jana Dobrovolna, null Pavel Janscak, null Marcel van Vugt, null Libor Macurek
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87ad7a32bff781c99611837832fa513d
https://doi.org/10.1002/1878-0261.13433/v2/response1
https://doi.org/10.1002/1878-0261.13433/v2/response1
Autor:
Zuzana Nascakova, Vaclav Urban, Barbora Boleslavska, Edita Vlachova, Jana Dobrovolna, Anna Oravetzova, Pavel Janscak
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 3740, p 3740 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 7
International Journal of Molecular Sciences
Volume 22
Issue 7
R-loops are three-stranded structures generated by annealing of nascent transcripts to the template DNA strand, leaving the non-template DNA strand exposed as a single-stranded loop. Although R-loops play important roles in physiological processes su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8654ddb1bd18d5a08b9267e8c38c9c0c
https://www.mdpi.com/1422-0067/22/7/3740
https://www.mdpi.com/1422-0067/22/7/3740
Publikováno v:
Genes
Genes, Vol 11, Iss 2, p 232 (2020)
Genes, Vol 11, Iss 2, p 232 (2020)
RECQ5 belongs to the RecQ family of DNA helicases. It is conserved from Drosophila to humans and its deficiency results in genomic instability and cancer susceptibility in mice. Human RECQ5 is known for its ability to regulate homologous recombinatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e399ac2beb741e0733f8b030c831eb
http://europepmc.org/articles/PMC7073763
http://europepmc.org/articles/PMC7073763
Autor:
Esin Isik, Nagaraja Chappidi, Martin Andrs, Antonio Porro, Chiara Balbo Pogliano, Jana Dobrovolna, Massimo Lopes, Pavel Janscak, Ralph Zellweger, Zuzana Nascakova, Shruti Menon, Barbora Boleslavska, Joao Matos
Publikováno v:
Molecular cell. 77(3)
Formation of co-transcriptional R-loops underlies replication fork stalling upon head-on transcription-replication encounters. Here, we demonstrate that RAD51-dependent replication fork reversal induced by R-loops is followed by the restart of semico
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b16cabcc2cd13aaa0efac0dbe2ef38b
https://pubmed.ncbi.nlm.nih.gov/31759821
https://pubmed.ncbi.nlm.nih.gov/31759821
RECQ5 helicase promotes resolution of conflicts between replication and transcription in human cells
Publikováno v:
The Journal of Cell Biology
Urban et al. show that RECQ5 DNA helicase promotes RAD18-dependent PCNA ubiquitination and the processing of replication intermediates upon collisions between replication and transcription complexes.
Collisions between replication and transcript
Collisions between replication and transcript
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d1bf107163f985648065bbbf4067958
https://doi.org/10.1083/jcb.201507099
https://doi.org/10.1083/jcb.201507099
Publikováno v:
Biophysical chemistry. 225
DNA replication is the most vulnerable process of DNA metabolism in proliferating cells and therefore it is tightly controlled and coordinated with processes that maintain genomic stability. Human RecQ helicases are among the most important factors i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b2045e19bad790391199064295b1051
https://pubmed.ncbi.nlm.nih.gov/27876204
https://pubmed.ncbi.nlm.nih.gov/27876204