Výsledky vyhledávání - "Jana Cesnekova"

YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis, and cell proliferation

Autor: Jiri Zeman, Daniela Fornuskova, Kamila Vinsova, Lukas Stiburek, Laszlo Wenchich, Olga Kostkova, Josef Houstek, Jana Cesnekova

Publikováno v: Molecular Biology of the Cell

Loss-of-function studies show that the human mitochondrial YME1L protease ensures cell proliferation, maintains normal cristae morphology and complex I activity, acts in an antiapoptotic manner, protects mitochondria from accumulation of oxidatively

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50fd59161f0245227f0a9e480c0e8c0f
https://doi.org/10.1091/mbc.e11-08-0674

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The mammalian homologue of yeast Afg1 ATPase (lactation elevated 1) mediates degradation of nuclear-encoded complex IV subunits

Autor: Marie Rodinova, Jana Cesnekova, Josef Houstek, Jiri Zeman, Hana Hansikova, Lukas Stiburek

Publikováno v: The Biochemical journal. 473(6)

Mitochondrial protein homeostasis is crucial for cellular function and integrity and is therefore maintained by several classes of proteins possessing chaperone and/or proteolytic activities. In the present study, we focused on characterization of LA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b34aa988550da5b1dd2b48b0108931d
https://pubmed.ncbi.nlm.nih.gov/26759378

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LACE1 interacts with p53 and mediates its mitochondrial translocation and apoptosis

Autor: Jana, Cesnekova, Jana, Spacilova, Hana, Hansikova, Josef, Houstek, Jiri, Zeman, Lukas, Stiburek

Publikováno v: Oncotarget

p53 is a major cellular tumor suppressor that in addition to its nuclear, transcription-dependent activity is also known to function extranuclearly. Cellular stressors such as reactive oxygen species can promote translocation of p53 into mitochondria

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::23150ef0f8e1c920a7e2a85192105d62
https://pubmed.ncbi.nlm.nih.gov/27323408

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Characterization of mitochondrial Lace1 ATPase (LB168)

Autor: Jana Cesnekova, Lukas Stiburek, Josef Houstek, Jiri Zeman

Publikováno v: The FASEB Journal. 28

Lace1 (Lactation elevated 1) is a human homolog of yeast Afg1 (ATPase family gene 1) ATPase with sequence identity ranging from 41,5 % H. sapiens vs. S. cerevisiae to 88,9 % H. sapiens vs. M. muscu...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cc7a6ef1f14fbbe9185eefc79ec80975
https://doi.org/10.1096/fasebj.28.1_supplement.lb168

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