Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Jana Šmardová"'
Autor:
Jana Šmardová
Mnohobuněcný organismus představuje spolecenstvi buněk, ktere se vyvijeji a vykonavaji svou funkci ve vymezenem case a prostoru pro maximalni užitek celeho systemu, jehož jsou soucasti. Nadory vznikaji z buněk, ktere porusuji zakladni pravidla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::890cedbefd1a53117c5f098ef6ab9ea9
https://doi.org/10.5817/cz.muni.m210-9700-2021
https://doi.org/10.5817/cz.muni.m210-9700-2021
Autor:
Jana Šmardová
Can the functioning of human society be compared to the functioning of tumors in the human body? How do tumors come about? Why are we so interested in them? What can we learn from them? In this book, the multicellular organism is presented as a compl
Autor:
Vincent Carbonnier, Flora Doffe, Andreas C. Joerger, Manon Tissier, Šárka Pavlová, Johanna Sofia Margareta Mattsson, Guido Kroemer, Isabelle Martins, Šárka Pospíšilová, B. Leroy, Patrick Micke, Thierry Soussi, Klas G. Wiman, Jana Šmardová
Publikováno v:
Cell Death and Differentiation
Cell Death and Differentiation, Nature Publishing Group, 2020, ⟨10.1038/s41418-020-00672-0⟩
Cell Death and Differentiation, 2020, ⟨10.1038/s41418-020-00672-0⟩
Cell Death and Differentiation, Nature Publishing Group, 2020, ⟨10.1038/s41418-020-00672-0⟩
Cell Death and Differentiation, 2020, ⟨10.1038/s41418-020-00672-0⟩
Infrequent and rare genetic variants in the human population vastly outnumber common ones. Although they may contribute significantly to the genetic basis of a disease, these seldom-encountered variants may also be miss-identified as pathogenic if no
Autor:
Jana Šmardová
Title in English: What can we learn from tumors?: Parallels in cell and human behavior Can the functioning of human society be compared to the functioning of tumors in the human body? How do tumors come about? Why are we so interested in them? What c
Autor:
Jitka Malčíková, Renata Hrabálková, Jana Šmardová, Lenka Zlamalikova, David Šálek, Mojmír Moulis, Jiri Jarkovsky, Barbora Ravčuková, Miluše Svitáková, Jan Šmarda, Kvetoslava Liskova
Publikováno v:
Oncology Reports. 38:2535-2542
Mutations and deletions of the tumor suppressor TP53 gene are the most frequent genetic alterations detected in human tumors, though they are rather less frequent in lymphomas. However, acquisition of the TP53 mutation was demonstrated to be one of t
Autor:
Mojmír Moulis, Jitka Malčíková, Jiri Mayer, Jana Šmardová, Martin Trbušek, Andrea Marečková, David Šálek, Karol Pál, Lenka Radová, Andrea Janíková, Nikola Tom, Leos Kren
Publikováno v:
Leukemialymphoma. 60(6)
Mantle cell lymphoma (MCL) is characterized by the hallmark t(11;14)(q13;q32) translocation, leading to cyclin D1 over-expression. Additionally, disrupting the DNA damage response pathway through ATM or TP53 defects plays an important role in MCL pat
Publikováno v:
Oncology Reports. 35:2673-2680
D-type cyclins are involved in cell cycle regulation and play an important role in the pathogenesis of lymphomas. Aberrant expression of cyclin D1 is associated with mantle cell lymphoma (MCL) and serves as a diagnostic marker of MCL. Analysis of cyc
Publikováno v:
Methods in Molecular Biology ISBN: 9781493988754
Chronic lymphocytic leukemia (CLL) represents a prototype disease in which TP53 gene defects lead to inferior prognosis. Here, we present two distinct methodologies which can be used to identify TP53 mutations in CLL patients; both protocols are prim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::396da0f8ce20b9628dbf62ece13955b5
https://doi.org/10.1007/978-1-4939-8876-1_6
https://doi.org/10.1007/978-1-4939-8876-1_6