Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jana, Peremartí"'
Publikováno v:
Metallomics. 12:2161-2173
Arsenic induces oncogenic effects activating stress-related signalling pathways. This can result in the over-activation of the AP-1 protein, specifically its FRA1 component. FRA1 is a transcription factor frequently overexpressed in epithelial tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87a356cdc1dd26cecc26817151b29134
https://doi.org/10.1039/d0mt00209g
https://doi.org/10.1039/d0mt00209g
Publikováno v:
Metallomics : integrated biometal science. 12(12)
Arsenic induces oncogenic effects activating stress-related signalling pathways. This can result in the over-activation of the AP-1 protein, specifically its FRA1 component. FRA1 is a transcription factor frequently overexpressed in epithelial tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::98cfeadc30e6b41d4578719737e7a3ad
https://pubmed.ncbi.nlm.nih.gov/33313624
https://pubmed.ncbi.nlm.nih.gov/33313624
Autor:
J C States, Laila Al-Eryani, Samantha F. Jenkins, Chendil Damodaran, Ashish Tyagi, Sabine Waigel, Jana Peremartí
Publikováno v:
Toxicological Sciences. 162:645-654
Arsenic is a widely distributed toxic natural element. Chronic arsenic ingestion causes several cancers, especially skin cancer. Arsenic-induced cancer mechanisms are not well defined, but several studies indicate that mutation is not the driving for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beedc736362e1912c994690a8bf6e2cb
https://doi.org/10.1093/toxsci/kfx292
https://doi.org/10.1093/toxsci/kfx292
Publikováno v:
Toxicology and Applied Pharmacology. 409:115303
DNA damage plays a crucial role in the transforming potential of the human carcinogen arsenic. The arsenic biotransformation enzyme AS3MT is known to participate in the generation of ROS after arsenic exposure, whereas MTH1 sanitizes oxidized dNTP po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f09c81b70280ec0501f4c094675d8a2
https://doi.org/10.1016/j.taap.2020.115303
https://doi.org/10.1016/j.taap.2020.115303
Publikováno v:
Archives of Toxicology. 90:1893-1905
Chronic exposure to arsenic is known to increase the incidence of cancer in humans. Our previous work demonstrated that environmentally relevant arsenic exposures generate an accelerated accumulation of pre-carcinogen 8-OH-dG DNA lesions under Ogg1-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3530e579ececeb37f3fdbe2da355abe8
https://doi.org/10.1007/s00204-015-1605-7
https://doi.org/10.1007/s00204-015-1605-7
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 779:144-151
Inorganic arsenic (i-As) is a genotoxic and carcinogenic environmental contaminant known to affect millions of people worldwide. Our previous work demonstrated that chronic sub-toxic i-As concentrations were able to induce biologically significant le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b97ac07add0b77d70d28f87f10097503
https://doi.org/10.1016/j.mrfmmm.2015.07.004
https://doi.org/10.1016/j.mrfmmm.2015.07.004
Publikováno v:
Toxicological Sciences. 142:93-104
Chronic arsenic exposure is known to enhance the genotoxicity/carcinogenicity of other DNA-damaging agents by inhibiting DNA repair activities. Interference with nucleotide excision repair and base excision repair are well documented, but interaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b64de8f5733472dc260ba6dad4bad844
https://doi.org/10.1093/toxsci/kfu159
https://doi.org/10.1093/toxsci/kfu159