Zobrazeno 1 - 10
of 204
pro vyhledávání: '"Jana, Kasparkova"'
Autor:
Sebastian W. Schleser, Oleksandr Krytovych, Tim Ziegelmeier, Elisabeth Groß, Jana Kasparkova, Viktor Brabec, Thomas Weber, Rainer Schobert, Thomas Mueller
Publikováno v:
Molecules, Vol 28, Iss 13, p 5173 (2023)
The purine derivative fludarabine is part of frontline therapy for chronic lymphocytic leukaemia (CLL). It has shown positive effects on solid tumours such as melanoma, breast, and colon carcinoma in clinical phase I studies. As the treatment of CLL
Externí odkaz:
https://doaj.org/article/6f38c7ca72b449aab20e84b085fab7f8
Autor:
Monika Hreusova, Vojtech Novohradsky, Lenka Markova, Hana Kostrhunova, Ivan Potočňák, Viktor Brabec, Jana Kasparkova
Publikováno v:
Bioinorganic Chemistry and Applications, Vol 2022 (2022)
In this work, gallium(III) complex with cloxyquin (5-chloro-8-quinolinol, HClQ) ligands is shown to effectively inhibit proliferation of rhabdomyosarcoma cells, the frequent, aggressive, and poorly treatable cancer of children. It offers striking sel
Externí odkaz:
https://doaj.org/article/9c53d497024647a2992bcd5d8fe8e554
Autor:
Jana Kasparkova, Hana Kostrhunova, Vojtech Novohradsky, Аlexey A. Logvinov, Viktor V. Temnov, Nataliya E. Borisova, Tatiana A. Podrugina, Lenka Markova, Pavel Starha, Alexey. A. Nazarov, Viktor Brabec
Publikováno v:
Bioinorganic Chemistry and Applications, Vol 2022 (2022)
One concept of improving anticancer effects of conventional platinum-based antitumor drugs consists of conjugating these compounds with other biologically (antitumor) active agents, acting by a different mechanism. Here, we present synthesis, physico
Externí odkaz:
https://doaj.org/article/3ca46adcbf094b3faac19d8bb49e9a33
Autor:
Jana Janockova, Jan Korabecny, Jana Plsikova, Katerina Babkova, Eva Konkolova, Dana Kucerova, Jana Vargova, Jan Koval, Rastislav Jendzelovsky, Peter Fedorocko, Jana Kasparkova, Viktor Brabec, Jan Rosocha, Ondrej Soukup, Slavka Hamulakova, Kamil Kuca, Maria Kozurkova
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 877-897 (2019)
A combination of biochemical, biophysical and biological techniques was used to study calf thymus DNA interaction with newly synthesized 7-MEOTA-tacrine thiourea 12–17 and urea heterodimers 18–22, and to measure interference with type I and II to
Externí odkaz:
https://doaj.org/article/6487d4fed0064893867020e3dda083eb
Autor:
Mueller, Sebastian W. Schleser, Oleksandr Krytovych, Tim Ziegelmeier, Elisabeth Groß, Jana Kasparkova, Viktor Brabec, Thomas Weber, Rainer Schobert, Thomas
Publikováno v:
Molecules; Volume 28; Issue 13; Pages: 5173
The purine derivative fludarabine is part of frontline therapy for chronic lymphocytic leukaemia (CLL). It has shown positive effects on solid tumours such as melanoma, breast, and colon carcinoma in clinical phase I studies. As the treatment of CLL
Autor:
Vojtech Novohradsky, Ilaria Zanellato, Cristina Marzano, Jitka Pracharova, Jana Kasparkova, Dan Gibson, Valentina Gandin, Domenico Osella, Viktor Brabec
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract We present the anticancer properties of cis, cis, trans-[Pt(IV)(NH3)2Cl2(OA)2] [Pt(IV)diOA] (OA = octanoato), Pt(IV) derivative of cisplatin containing two OA units appended to the axial positions of a six-coordinate Pt(IV) center. Our resul
Externí odkaz:
https://doaj.org/article/8c8d7ac8a35249ac83c6856771eb6c7d
Autor:
Vojtech Novohradsky, Lenka Markova, Hana Kostrhunova, Marie Svitelova, Jana Kasparkova, Alessandra Barbanente, Paride Papadia, Nicola Margiotta, James D. Hoeschele, Viktor Brabec
Publikováno v:
Inorganic Chemistry Frontiers. 9:3295-3305
Here, we investigated the mechanism of antiproliferative action in cancer cells of new compounds structurally derived from oxaliplatin, namely a pair of enantiomers [Pt(OXA)(1R,2R-DACHEX)] (1) and [Pt(OXA)(1S,2S-DACHEX)] (2) (OXA = oxalate, DACHEX =
Autor:
Clément Soulié, Jana Kasparkova, Cinzia Imberti, Viktor Brabec, Guy J. Clarkson, Huayun Shi, Martin J. Paterson, Olga Novakova, Peter J. Sadler
Publikováno v:
Chemistry (Weinheim an Der Bergstrasse, Germany)
Photoactivatable agents offer the prospect of highly selective cancer therapy with low side effects and novel mechanisms of action that can combat current drug resistance. 1,8‐Naphthalimides with their extended π system can behave as light‐harve
Autor:
Viktor Brabec, Natalia Cutillas, Hana Kostrhunova, Jana Kasparkova, Vojtech Novohradsky, José Ruiz, Gloria Vigueras, Alicia Marco, Lenka Markova
Publikováno v:
Inorganic Chemistry Frontiers. 8:4696-4711
Several anticancer chemotherapies, while eliminating the bulk of tumor cells, often fail, as they do not obliterate a small fraction of malignant cancer stem cells (CSCs). Thus, developing chemotherapeutics capable of targeting and abrogating CSCs, i
Publikováno v:
Dalton Transactions. 50:8017-8028
Complexes [Ru(η6-pcym)(bpydca)Cl]PF6 (Rudca) and [Ir(η5-Cp*)(bpydca)Cl]PF6 (Irdca) were developed as model compounds for the investigation of multi-targeted ester-functionalized half-sandwich ruthenium(II) and iridium(III) complexes; pcym = 1-methy