Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Jan-Willem Theunissen"'
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0219999 (2019)
While pigs and rabbits are used as models for human immune diseases, FcγR binding is poorly characterized in both test species. To evaluate antibody binding to FcγRIIIA, a receptor involved in antibody-dependent cellular cytotoxicity, chimerized an
Externí odkaz:
https://doaj.org/article/da49978ff79a4f018a5599a517d06552
Autor:
Thi-Sau Migone, Zoia Levashova, Sebastian Guelman, Ryan Dorfman, Andrew D. Avery, Anthony B. Cooper, Maryam M. Bhatti, Allen G. Cai, Jan-Willem Theunissen
The primary function of tissue factor (TF) resides in the vasculature as a cofactor of blood clotting; however, multiple solid tumors aberrantly express this transmembrane receptor on the cell surface. Here, we developed anti-TF antibody–drug conju
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a9af9f3eb10a892b4846b80595d9a01
https://doi.org/10.1158/1535-7163.c.6537849.v1
https://doi.org/10.1158/1535-7163.c.6537849.v1
Autor:
Thi-Sau Migone, Zoia Levashova, Sebastian Guelman, Ryan Dorfman, Andrew D. Avery, Anthony B. Cooper, Maryam M. Bhatti, Allen G. Cai, Jan-Willem Theunissen
Supplementary Table S1. Screening Data; Supplementary Table S2. Binding Data; Supplementary Table S3. TGA Data; Supplementary Table S4. ADC Data With Ranking
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69db7bae4996febd810a10a32193713f
https://doi.org/10.1158/1535-7163.22504785
https://doi.org/10.1158/1535-7163.22504785
Autor:
Thi-Sau Migone, Zoia Levashova, Sebastian Guelman, Ryan Dorfman, Andrew D. Avery, Anthony B. Cooper, Maryam M. Bhatti, Allen G. Cai, Jan-Willem Theunissen
Supplementary Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ab831a13a6726f0627401e143473ccb
https://doi.org/10.1158/1535-7163.22504788.v1
https://doi.org/10.1158/1535-7163.22504788.v1
Autor:
Sindy Liao-Chan, Barbara Daine-Matsuoka, Nathan Heald, Tiffany Wong, Tracey Lin, Allen G Cai, Michelle Lai, Joseph A D'Alessio, Jan-Willem Theunissen
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0124708 (2015)
Antibodies against cell surface antigens may be internalized through their specific interactions with these proteins and in some cases may induce or perturb antigen internalization. The anti-cancer efficacy of antibody-drug conjugates is thought to r
Externí odkaz:
https://doaj.org/article/36d07d62512441548835e2f6c9405095
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 7, p e0219999 (2019)
PLoS ONE, Vol 14, Iss 7, p e0219999 (2019)
While pigs and rabbits are used as models for human immune diseases, FcγR binding is poorly characterized in both test species. To evaluate antibody binding to FcγRIIIA, a receptor involved in antibody-dependent cellular cytotoxicity, chimerized an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b9bb6dccefa3c0e9414ffe2badd01a3
https://pubmed.ncbi.nlm.nih.gov/31323052
https://pubmed.ncbi.nlm.nih.gov/31323052
Autor:
Allen G. Cai, Ryan Dorfman, Thi-Sau Migone, Avery Andrew, Sebastian Guelman, Cooper Anthony, Zoia Levashova, Jan-willem Theunissen, Maryam M. Bhatti
Publikováno v:
Molecular cancer therapeutics. 17(11)
The primary function of tissue factor (TF) resides in the vasculature as a cofactor of blood clotting; however, multiple solid tumors aberrantly express this transmembrane receptor on the cell surface. Here, we developed anti-TF antibody–drug conju
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6d114a6e46087c6a73c7738a64fa338
https://pubmed.ncbi.nlm.nih.gov/30126944
https://pubmed.ncbi.nlm.nih.gov/30126944
Autor:
Randall L. Halcomb, Amanda Valdiosera, David Y. Jackson, Lawrence Chinn, Jonathan S. Melnick, Migone Thi Sau, Mark R. Flory, Derrick Houser, Edward H. van der Horst, Maureen Fitch-Bruhns, Simeon Bowers, Edward Ha, Jorge Monteon, Jan Willem Theunissen, Gary Probst, Tiffany Wong, Paul W. Sauer, Zoia Levashova, Kristy Venstrom, Abel Bermudez, Sindy Liao-Chan, Christopher R. Behrens
Publikováno v:
Mol Pharm
Conventional antibody–drug conjugates (ADCs) are heterogeneous mixtures of chemically distinct molecules that vary in both drugs/antibody (DAR) and conjugation sites. Suboptimal properties of heterogeneous ADCs have led to new site-specific conjuga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d883318e923b6b79e4a53f04cf24bb2c
https://doi.org/10.1021/acs.molpharmaceut.5b00432
https://doi.org/10.1021/acs.molpharmaceut.5b00432
Publikováno v:
Cancer Research. 69:6007-6010
Ligand-dependent and ligand-independent activation of the Hedgehog (Hh) signaling pathway is involved in tumorigenesis. The importance of mutations in Hh pathway components leading to constitutive signaling has been well established in basal cell car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c559f2187cddaad3c67aa309bc5184b
https://doi.org/10.1158/0008-5472.can-09-0756
https://doi.org/10.1158/0008-5472.can-09-0756
Autor:
Gregory M, Hayes, Belinda, Cairns, Zoia, Levashova, Lawrence, Chinn, Myra, Perez, Jan-Willem, Theunissen, Sindy, Liao-Chan, Abel, Bermudez, Mark R, Flory, Karl J, Schweighofer, Edward, H van der Horst
Publikováno v:
American journal of translational research. 7(6)
Soft tissue sarcoma (STS) is a heterogenous tumor arising from the embryonic mesoderm represented by approximately 50 histological subtypes. Effective therapeutic intervention is lacking for recurrent, late stage and metastatic disease. CD39, a cell-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7fb25e0153d13a8f2d5c3b6112897862
https://pubmed.ncbi.nlm.nih.gov/26279761
https://pubmed.ncbi.nlm.nih.gov/26279761