Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Jan-Willem N. Akkerman"'
Autor:
Eelo Gitz, Charlotte D. Koopman, Alèkos Giannas, Cornelis A Koekman, Dave J. van den Heuvel, Hans Deckmyn, Jan-Willem N. Akkerman, Hans C. Gerritsen, Rolf T. Urbanus
Publikováno v:
Haematologica, Vol 98, Iss 11 (2013)
Initial platelet arrest at the exposed arterial vessel wall is mediated through glycoprotein Ibα binding to the A1 domain of von Willebrand factor. This interaction occurs at sites of elevated shear force, and strengthens upon increasing hydrodynami
Externí odkaz:
https://doaj.org/article/416b501626d346d48127422e50bd7fd3
Autor:
Rolf T. Urbanus, Dianne E. van der Wal, Cornelis A. Koekman, Albert Huisman, Dave J. van den Heuvel, Hans C. Gerritsen, Hans Deckmyn, Jan-Willem N. Akkerman, Roger E.G. Schutgens, Eelo Gitz
Publikováno v:
Haematologica, Vol 98, Iss 7 (2013)
Externí odkaz:
https://doaj.org/article/d02b378c30ff454daad639326dab94f2
Autor:
Rehana Perveen, Kevin Funk, Jean Thuma, Shelli Wulf Ridge, Yanyan Cao, Jan Willem N Akkerman, Xiaozhuo Chen, Huzoor Akbar
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e26238 (2011)
BACKGROUND: We have shown that 1,2,3,4,6-penta-O-galloyl-α-D-glucopyranose (α-PGG), an orally effective hypoglycemic small molecule, binds to insulin receptors and activates insulin-mediated glucose transport. Insulin has been shown to bind to its
Externí odkaz:
https://doaj.org/article/ab2c3a8c656f4bb787bb22398ab2b269
Autor:
Jan-Willem N. Akkerman
Publikováno v:
Energetics of Secretion Responses ISBN: 9781315150970
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5bba031a1b28a7f2dc17a3db16453fb
https://doi.org/10.1201/9781315150970-1
https://doi.org/10.1201/9781315150970-1
Autor:
Cornelis A. Koekman, Dianne E. van der Wal, Sabine Versteeg, Eelo Gitz, Kimberly S.L. Lo, Jan Willem N. Akkerman, Vivian X. Du
Publikováno v:
Haematologica. 97:1514-1522
Background Cold storage of platelets reduces bacterial growth and preserves their hemostatic properties better than current procedures do. However, storage at 0°C induces [14-3-3ζ-glycoprotein Ibα] association, 14-3-3ζ release from phospho-Bad, B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af83809d1c88b18d856be0486640755
https://doi.org/10.3324/haematol.2011.059956
https://doi.org/10.3324/haematol.2011.059956
Autor:
Erik Tournoij, Jan-Willem N. Akkerman, Vivian X. Du, Arnold C. Koekman, Rob Ruijtenbeek, Mark Roest, Frans L. Moll
Publikováno v:
Platelets. 23:617-625
The main responses of P2Y(1) ligation are platelet shape change and transient aggregation while P2Y(12) ligation amplifies P2Y(1)-induced aggregation and accelerates aggregation, secretion and thromboxane A(2) production induced by other agonist-rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79578bed00fbb61a1c090d8125ed648d
https://doi.org/10.3109/09537104.2011.645924
https://doi.org/10.3109/09537104.2011.645924
Publikováno v:
Diabetes
OBJECTIVE Patients with type 2 diabetes have an increased risk of cardiovascular disease and show abnormalities in the coagulation cascade. We investigated whether increased synthesis of tissue factor (TF) by platelets could contribute to the hyperco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d1ff34c31d773c040c06ea9322ac327
https://doi.org/10.2337/db09-1008
https://doi.org/10.2337/db09-1008
Autor:
E. Tournoij, Jan Willem N. Akkerman, Stefan Schulte-Merker, Frans L. Moll, Leonard I. Zon, P. G. De Groot, Gerhard J. Weber
Publikováno v:
Journal of Thrombosis and Haemostasis, 8(3), 588-595. Wiley-Blackwell
Summary. Background: We have used the advantages of the zebrafish model system to demonstrate which of the vertebrate Myosin Light Chain Kinase (MLCK) genes is expressed in thrombocytes and important for thrombus formation. Methods and Results: Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd9bbf7996af330064a32211f67e8f9f
https://hdl.handle.net/20.500.11755/37b3e8e5-25de-443b-9fe5-0170f1ffd7ad
https://hdl.handle.net/20.500.11755/37b3e8e5-25de-443b-9fe5-0170f1ffd7ad
Autor:
Willem H. Ouwehand, Nilesh J. Samani, Panos Deloukas, Frank Dudbridge, Jan-Willem N. Akkerman, Sarah L. Bray, Alison J. Coffey, Michael Steward, Marc Hoylaerts, Jonathan Stephens, Catherine M. Rice, Angela Rankin, Alison H. Goodall, Nicholas A. Watkins, Stephen F. Garner, Adam Walker, Philippa Burns, David Bentley, Jane Rogers, Richard W. Farndale, Chris I. Jones, Mark E. Earthrowl, W. Angenent, Kerstin Koch, Bernard de Bono
Publikováno v:
Blood. 114:1405-1416
Platelet response to activation varies widely between individuals but shows interindividual consistency and strong heritability. The genetic basis of this variation has not been properly explored. We therefore systematically measured the effect on fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::754778b171d8f70653c2447c3cd566aa
https://doi.org/10.1182/blood-2009-02-202614
https://doi.org/10.1182/blood-2009-02-202614
Publikováno v:
Scandinavian Journal of Haematology. 17:71-77
Gel filtered platelet suspensions were concentrated by repeated dehydration against polyethyleneglycol 20,000 followed by dialysis against slightly hypotonic buffer. This method increased the platelet concentration 2-3 times with a recovery of 80-100
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77740a3ae819b1548af99a6d5f2db9d9
https://doi.org/10.1111/j.1600-0609.1976.tb02843.x
https://doi.org/10.1111/j.1600-0609.1976.tb02843.x