Zobrazeno 1 - 10
of 227
pro vyhledávání: '"Jan-Willem N. Akkerman"'
Autor:
Eelo Gitz, Charlotte D. Koopman, Alèkos Giannas, Cornelis A Koekman, Dave J. van den Heuvel, Hans Deckmyn, Jan-Willem N. Akkerman, Hans C. Gerritsen, Rolf T. Urbanus
Publikováno v:
Haematologica, Vol 98, Iss 11 (2013)
Initial platelet arrest at the exposed arterial vessel wall is mediated through glycoprotein Ibα binding to the A1 domain of von Willebrand factor. This interaction occurs at sites of elevated shear force, and strengthens upon increasing hydrodynami
Externí odkaz:
https://doaj.org/article/416b501626d346d48127422e50bd7fd3
Autor:
Rolf T. Urbanus, Dianne E. van der Wal, Cornelis A. Koekman, Albert Huisman, Dave J. van den Heuvel, Hans C. Gerritsen, Hans Deckmyn, Jan-Willem N. Akkerman, Roger E.G. Schutgens, Eelo Gitz
Publikováno v:
Haematologica, Vol 98, Iss 7 (2013)
Externí odkaz:
https://doaj.org/article/d02b378c30ff454daad639326dab94f2
Autor:
Dianne E. van der Wal, Eelo Gitz, Vivian X. Du, Kimberly S.L. Lo, Cornelis A. Koekman, Sabine Versteeg, Jan Willem N. Akkerman
Publikováno v:
Haematologica, Vol 97, Iss 10 (2012)
Background Cold storage of platelets reduces bacterial growth and preserves their hemostatic properties better than current procedures do. However, storage at 0°C induces [14-3-3ζ-glycoprotein Ibα] association, 14-3-3ζ release from phospho-Bad, B
Externí odkaz:
https://doaj.org/article/e044bb58444c49e592cf512d08810e0b
Autor:
Anja J. Gerrits, Eelo Gitz, Cornelis A. Koekman, Frank L. Visseren, Timon W. van Haeften, Jan Willem N. Akkerman
Publikováno v:
Haematologica, Vol 97, Iss 8 (2012)
Background In normal platelets, insulin inhibits agonist-induced Ca2+ mobilization by raising cyclic AMP. Platelet from patients with type 2 diabetes are resistant to insulin and show increased Ca2+ mobilization, aggregation and procoagulant activity
Externí odkaz:
https://doaj.org/article/f5fd389423f24b9eb86cf34500b6bebb
Autor:
Rehana Perveen, Kevin Funk, Jean Thuma, Shelli Wulf Ridge, Yanyan Cao, Jan Willem N Akkerman, Xiaozhuo Chen, Huzoor Akbar
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e26238 (2011)
BACKGROUND: We have shown that 1,2,3,4,6-penta-O-galloyl-α-D-glucopyranose (α-PGG), an orally effective hypoglycemic small molecule, binds to insulin receptors and activates insulin-mediated glucose transport. Insulin has been shown to bind to its
Externí odkaz:
https://doaj.org/article/ab2c3a8c656f4bb787bb22398ab2b269
Autor:
Tessa A.M. Steevels, Geertje H.A. Westerlaken, Marloes R. Tijssen, Paul J. Coffer, Peter J. Lenting, Jan Willem N. Akkerman, Linde Meyaard
Publikováno v:
Haematologica, Vol 95, Iss 12 (2010)
Background The collagen receptor glycoprotein VI generates activating signals through an immunoreceptor tyrosine-based activating motif on the co-associated Fc receptor gamma chain. Leukocyte-associated immunoglobulin-like receptor-1 also ligates col
Externí odkaz:
https://doaj.org/article/3f7316c7d4af4d58881b6bf4885a4ca0
Autor:
Jan-Willem N. Akkerman
Publikováno v:
Energetics of Secretion Responses ISBN: 9781315150970
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5bba031a1b28a7f2dc17a3db16453fb
https://doi.org/10.1201/9781315150970-1
https://doi.org/10.1201/9781315150970-1
Autor:
Steve Jupe, Johan W. M. Heemskerk, Susanne M. de Witt, Christian Weber, Nadine J.A. Mattheij, Marion A.H. Feijge, Myrto Kostadima, David J. Adams, Jacqueline K. White, Judith M.E.M. Cosemans, Willem H. Ouwehand, Oliver Soehnlein, Martin H. Prins, Luigi Grassi, Stuart Meacham, Jan Willem N. Akkerman, Frauke Swieringa, Constance C.F.M.J. Baaten, Ramiro Ramirez-Solis
Publikováno v:
Blood, 132(24), E35. American Society of Hematology
Blood, 132(24), E35-E46. The American Society of Hematology
Blood, 132(24), E35-E46. The American Society of Hematology
Antithrombotic therapies reduce cardiovascular diseases by preventing arterial thrombosis and thromboembolism, but at expense of increased bleeding risks. Arterial thrombosis studies using genetically modified mice have been invaluable for identifica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d11317083a683bd8ac032b0599ffcb
https://dspace.library.uu.nl/handle/1874/377309
https://dspace.library.uu.nl/handle/1874/377309
Autor:
Cornelis A. Koekman, Dianne E. van der Wal, Sabine Versteeg, Eelo Gitz, Kimberly S.L. Lo, Jan Willem N. Akkerman, Vivian X. Du
Publikováno v:
Haematologica. 97:1514-1522
Background Cold storage of platelets reduces bacterial growth and preserves their hemostatic properties better than current procedures do. However, storage at 0°C induces [14-3-3ζ-glycoprotein Ibα] association, 14-3-3ζ release from phospho-Bad, B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af83809d1c88b18d856be0486640755
https://doi.org/10.3324/haematol.2011.059956
https://doi.org/10.3324/haematol.2011.059956
Autor:
Erik Tournoij, Jan-Willem N. Akkerman, Vivian X. Du, Arnold C. Koekman, Rob Ruijtenbeek, Mark Roest, Frans L. Moll
Publikováno v:
Platelets. 23:617-625
The main responses of P2Y(1) ligation are platelet shape change and transient aggregation while P2Y(12) ligation amplifies P2Y(1)-induced aggregation and accelerates aggregation, secretion and thromboxane A(2) production induced by other agonist-rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79578bed00fbb61a1c090d8125ed648d
https://doi.org/10.3109/09537104.2011.645924
https://doi.org/10.3109/09537104.2011.645924