Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jan-Rung Mo"'
Autor:
Manfred Kraus, Yuxun Wang, Dan Aleksandrowicz, Eric Bachman, Alexander A Szewczak, Deborah Walker, Lin Xu, Melaney Bouthillette, Kaleen M Childers, Brian Dolinski, Andrew M Haidle, Johnny Kopinja, Linda Lee, Jongwon Lim, Kevin D Little, Yanhong Ma, Anjili Mathur, Jan-Rung Mo, Erin O'Hare, Ryan D Otte, Brandon M Taoka, Wenxian Wang, Hong Yin, Anna A Zabierek, Weisheng Zhang, Shuxia Zhao, Joe Zhu, Jonathan R Young, C Gary Marshall
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37207 (2012)
A high percentage of patients with the myeloproliferative disorder polycythemia vera (PV) harbor a Val617→Phe activating mutation in the Janus kinase 2 (JAK2) gene, and both cell culture and mouse models have established a functional role for this
Externí odkaz:
https://doaj.org/article/e1af821b8d2243da83151c870eaab2ae
Autor:
Jan-Rung Mo, Anjili Mathur, Minilik Angagaw, Shuxia Zhao, Yuxun Wang, Diana Gargano, Alessandra DiBacco, Eric S Bachman
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e7286 (2009)
Splenic enlargement (splenomegaly) develops in numerous disease states, although a specific pathogenic role for the spleen has rarely been described. In polycythemia vera (PV), an activating mutation in Janus kinase 2 (JAK2(V617)) induces splenomegal
Externí odkaz:
https://doaj.org/article/710f5ab188684f0988a70f6dc513a604
Autor:
Jennifer R. Molina, Joseph M. Gozgit, Melissa M. Vasbinder, Ryan P. Abo, Kaiko kunii, Kristy G. Kuplast-Barr, Bin Gui, Sunaina P. Nayak, Elena Minissale, Kerren K. Swinger, Tim J. Wigle, Alvin Z. Lu, Danielle J. Blackwell, Christina R. Majer, Yue Ren, Ellen Bamberg, Mario Niepel, Jan-Rung Mo, William D. Church, Ahmed S. Mady, Jeff Song, Zacharenia A. Varsamis, Luke Utley, Patricia E. Rao, Timoty J. Mitchison, Kevin W. Kuntz, Victoria M. Richon, Kristen McEachern, Heike Keilhack
Publikováno v:
Cancer Research. 82:2154-2154
Targeting cytosolic nucleic acid sensing pathways to activate the Type I interferon (IFN) response is an emerging therapeutic strategy being explored in oncology. The PARP family consists of seventeen enzymes that regulate fundamental biological proc
Autor:
Tim J. Wigle, Luke Utley, Kevin Wayne Kuntz, Jeff Song, Jan-Rung Mo, W. David Church, Sunaina P. Nayak, Heike Keilhack, Yue Ren, Alvin Lu, Danielle J. Blackwell, Ryan Abo, Kaiko Kunii, Christina R. Majer, Ahmed S.A. Mady, Melissa M. Vasbinder, Ellen Bamberg, Kerren Kalai Swinger, Bin Gui, Victoria M. Richon, Mario Niepel, Patricia E. Rao, Kristy Kuplast-Barr, Jennifer R. Molina, Timothy J. Mitchison, Joseph M. Gozgit, Elena Minissale, Zacharenia A. Varsamis
Publikováno v:
Cancer cell. 39(9)
PARP7 is a monoPARP that catalyzes the transfer of single units of ADP-ribose onto substrates to change their function. Here, we identify PARP7 as a negative regulator of nucleic acid sensing in tumor cells. Inhibition of PARP7 restores type I interf
Autor:
Tim J. Wigle, Elena Minissale, Alvin Lu, Kristy Kuplast-Barr, W. David Church, Jennifer R. Molina, Heike Keilhack, Kaiko Kunii, Anne Cheung, Yue Ren, Christina R. Majer, Christopher Reik, Kevin Wayne Kuntz, Mario Niepel, Victoria M. Richon, Laurie B. Schenkel, Kerren Kalai Swinger, Jan-Rung Mo, Danielle J. Blackwell, Ryan Abo, Melissa M. Vasbinder
Publikováno v:
Cell Chemical Biology. 28:1158-1168.e13
Summary PARP14 has been implicated by genetic knockout studies to promote protumor macrophage polarization and suppress the antitumor inflammatory response due to its role in modulating interleukin-4 (IL-4) and interferon-γ signaling pathways. Here,
Autor:
Luke Utley, Kaiko Kunii, Danielle J. Blackwell, Ryan Abo, Jan-Rung Mo, Mario Niepel, Yue Ren, David Church, Joseph M. Gozgit, Kevin Wayne Kuntz, Patricia E. Rao, Kerren Kalai Swinger, Jeff Song, Melissa Vasbinder, Kristy Kuplast-Barr, Victoria M. Richon, Timothy J. Mitchison, Christina R. Majer, Alvin Lu, Bin Gui, Jennifer R. Molina, Elena Minissale, Heike Keilhack, Tim J. Wigle, Ellen Bamberg
Publikováno v:
Cancer Research. 81:48-48
Targeting cytosolic nucleic acid sensing pathways and the Type I interferon (IFN) response is an emerging therapeutic strategy being explored in oncology. The PARP family consists of seventeen enzymes that regulate fundamental biological processes in
Autor:
Alvin Lu, Ryan Abo, Jan-Rung Mo, Kevin Wayne Kuntz, Victoria M. Richon, Patrick Flynn, Melissa Vasbinder, Timothy J. Mitchison, Mario Niepel, Andrew G. Santospago, Bin Gui, Heike Keilhack, Joseph M. Gozgit, Zacharenia A. Varsamis
Publikováno v:
Cancer Research. 81:1021-1021
Genomic instability in cancer cells leads to cellular stress through the accumulation of aberrant nucleic acid species in the cytosol. We have shown that PARP7, a monoPARP, is a negative regulator of cytosolic nucleic acid sensing in cancer cells. RB
Autor:
Alvin Lu, Tim J. Wigle, Yue Ren, Mario Niepel, Danielle J. Blackwell, Ryan Abo, Bin Gui, Heike Keilhack, Jan-Rung Mo
Publikováno v:
Biochemical pharmacology. 167
Poly-ADP-ribose polymerases (PARPs) are a family of enzymes responsible for transferring individual or chains of ADP-ribose subunits to substrate targets as a type of post-translational modification. PARPs regulate a wide variety of important cellula
Autor:
Danielle J. Blackwell, Ryan Abo, Christina R. Majer, Jan-Rung Mo, Victoria M. Richon, Yue Ren, Alvin Lu, Luke Utley, Zacharenia A. Varsamis, Tim J. Wigle, Mario Niepel, Bin Gui, Kevin Wayne Kuntz, Jeff Song, Kerren Kalai Swinger, Kaiko Kunii, William Church, Sunaina P. Nayak, Joseph M. Gozgit, Melissa Vasbinder, Ellen Bamberg, Patricia E. Rao, Kristy Kuplast-Barr, Heike Keilhack, Timothy J. Mitchison
Publikováno v:
Cancer Research. 80:3405-3405
Targeting cytosolic nucleic acid sensing pathways and the Type I interferon (IFN) response is an emerging therapeutic strategy being explored in oncology. PARP7 is a member of the monoPARP class of enzymes, which catalyze the transfer of single units
Autor:
Patricia E. Rao, Danielle J. Blackwell, Ryan Abo, Kaiko Kunii, Kristy Kuplast-Barr, W. David Church, Victoria M. Richon, Heike Keilhack, Melissa M. Vasbinder, Jan-Rung Mo, Luke Utley, Ellen Bamberg, Mario Niepel, Zacharenia A. Varsamis, Yue Ren, Alvin Lu, Timothy J. Mitchison, Tim J. Wigle, Christina R. Majer, Kevin Wayne Kuntz, Jeff Song, Kerren Kalai Swinger, Joseph M. Gozgit, Bin Gui, Sunaina P. Nayak
Publikováno v:
Cancer Research. 80:DDT02-01
RBN-2397: A first-in-class PARP7 inhibitor targeting a newly discovered cancer vulnerability in stress-signaling pathways PARP7 is a monoPARP that catalyzes the transfer of single units of ADP-ribose onto substrates to change their function (MARylati