Výsledky vyhledávání - "Jan-Remt Mellema"

Sensitivity of 1H NMR Analysis of Rat Urine in Relation to Toxicometabonomics. Part I: Dose-Dependent Toxic Effects of Bromobenzene and Paracetamol

Autor: Carol Thijssen-van Zuylen, Willem G.E.J. Schoonen, Pieter Zandberg, Martin J. Smit, G. Jean Horbach, Joop H. J. van Nesselrooij, Jan-Remt Mellema, Jack T. W. E. Vogels, Albert C. Tas, Jan-Peter H. T. M. Ploemen, Cathelijne P. A. M. Kloks

Publikováno v: Toxicological Sciences. 98:271-285

1H nuclear magnetic resonance (NMR) spectroscopy of rat urine in combination with pattern recognition analysis was evaluated for early noninvasive detection of toxicity of investigational chemical entities. Bromobenzene (B) and paracetamol (P) were a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdfc337fbdadb07e10ff359f447d8713
https://doi.org/10.1093/toxsci/kfm076

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Synthesis and NMR-analysis of deuterated and tritiated cyclooctyl acetic acid

Autor: Carel W. Funke, Jan-Remt Mellema, Frans M. Kaspersen, Gerard N. Wagenaars, Irene H. G. Schlachter

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 29:613-616

To increase the bio-availability of naturally occurring steroids, esterification of the 17-hydroxy position is a useful approach. Besides (branched) alkanecarboxylic acids1) and cyclohexanecarboxylic acid2) also cyclooctyl acetic acid (1) was applied

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bda9360234f9febc283ef64502b55567
https://doi.org/10.1002/jlcr.2580290514

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Uniform procedure of (1)H NMR analysis of rat urine and toxicometabonomics Part II: comparison of NMR profiles for classification of hepatotoxicity

Autor: Martin J. Smit, G. Jean Horbach, Jan-Peter H. T. M. Ploemen, Willem G.E.J. Schoonen, Pieter Zandberg, Cathelijne P. A. M. Kloks, Jack T. W. E. Vogels, Albert C. Tas, Jan-Remt Mellema, Joop H. J. van Nesselrooij, Carol Thijssen-vanZuylen

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology. 98(1)

A procedure of nuclear magnetic resonance (NMR) urinalysis using pattern recognition is proposed for early detection of toxicity of investigational compounds in rats. The method is applied to detect toxicity upon administration of 13 toxic reference

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51cc67d7b7e9bcea3ef8be7d01ca589b
https://pubmed.ncbi.nlm.nih.gov/17420222

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Synthesis of the self-complementary RNA-DNA hybrid:R(GCG)D(TATACGC)

Autor: G. Wille, Andrew H.-J. Wang, C. A. A. Van Boeckel, Cornelis Altona, H. P. Westerink, J. H. Van Boom, Jan-Remt Mellema, G. A. Van Der Marel

Publikováno v: Recueil des Travaux Chimiques des Pays-Bas. 100:389-390

A nucleic acid fragment containing a RNA trimer and a DNA heptamer wich are linked by a 3′-5′-internucleotide phosphodiester bond has been synthesized by a phosphotriester approach. The sequence of the nucleosides is such that they will form a se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::40af3912c5a353069ee460a364dcc30f
https://doi.org/10.1002/recl.19811001011

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Complete assignment and conformational analysis of a deoxyribotetranucleotide, d(TAAT). A 360 and 500 MHz NMR study

Autor: Cornelis Altona, C. A. G. Haasnoot, Jan-Remt Mellema, Jacques H. van Boom

Publikováno v: Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis. 655:256-264

A proton NMR study at 360 MHz and 500 MHz was carried out on the tetranucleoside triphosphate d(TAAT) at a temperature of 27 degrees C. Extensive decoupling experiments allowed a complete and unambiguous spectral assignment. The data are interpreted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::396bebc36890479fb253a1fa8ea17608
https://doi.org/10.1016/0005-2787(81)90016-2

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Conformational aspects of malic acid: A multidisciplinary approach

Autor: Jan-Remt Mellema, Pieter F. W. Stouten, Jan Kroon, Bas R. Leeflang, Bouke P. van Eijck

Publikováno v: Journal of Molecular Structure. 189:65-80

Malic acid molecules can adopt three different staggered conformations of minimum energy with respect to rotation around the central C-C bond: gauche - (g- ), trans (t) and gauche + (g+ ). The conformational behaviour of the acid and of its dissociat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::264e328ea10dbcc83b170ee1209c6cb7
https://doi.org/10.1016/0022-2860(88)80213-8

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Conformational analysis of the single-helical DNA fragment d(T-A-A-T) in aqueous solution. The combined use of NMR proton chemical shifts and coupling constants obtained at 300 MHz and 500 MHz

Autor: Cornelis Altona, Jacques H. van Boom, Jan-Remt Mellema, Cornelis A. G. Haasnoot, August K. Jellema

Publikováno v: European Journal of Biochemistry. 141:165-175

Proton NMR studies at 300 MHz and 500 MHz were carried out on the tetranucleoside trisphosphate d(T-A-A-T). The thermodynamics of the three stacking interactions, derived from chemical shift versus temperature profiles, were used to extrapolate the o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::917355b486c00724f8b02b12c0be9e52
https://doi.org/10.1111/j.1432-1033.1984.tb08171.x

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Synthesis of Fragments of the Capsular Polysaccharide of Haemophilus Influnzae Type B Part II. Preparation and Structural Analysis of Fragments Comprising two and Three Repeating Units

Autor: Jan-Remt Mellema, P. Hoogerhout, Gerard N. Wagenaars, D. Evenberg, C. A. A. Van Boeckel, Jan Poolman, G. A. Van Der Marel, A. W. M. Lefeber, J. H. Van Booma, Carel W. Funke

Publikováno v: Journal of Carbohydrate Chemistry. 7:399-416

The synthesis of spacer-containing fragments of the capsular poly-saccharide of H. influenzas, comprising two and three repeating units (9a and 9b, respectively), is presented. Ribosylribitol building blocks 1 and 2 were coupled with bis [1-benzotria

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0a39bbc02783d0d89ca92068315d1ce
https://doi.org/10.1080/07328308808058933

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Proton NMR study and confomiational analysis of d(CGT), d(TCG) and (CGTCG) in aqueous solution. The effect of a dangling thymidlne and of a tbymidine mismatch on DNA mini-duplexes

Autor: Gijs A. van der Marel, Comelis Altona, Jacques H. van Boom, Rob van der Woerd, Jan-Remt Mellema

Publikováno v: Nucleic Acids Research. 12:5061-5078

Proton NMR studies of d(CGT), d(TCG) and d(CGTCG) were carried out at 300 and 500 MHz. The temperature and concentration dependence of the chemical shifts of various resonances indicates duplex formation only in the cases of d(TCG) and d(CGTCG). It i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f28a5b59e71d13547af7dc8893a931fe
https://doi.org/10.1093/nar/12.12.5061

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Sequence-dependent structural variation in single-helical DNA. Proton NMR studies of d(T-A-T-A) and d(A-T-A-T) in aqueous solution

Autor: Jan-Remt Mellema, Cornelis Altona, Jacques H. van Boom, Gijs A. van der Marel, Cornelis A. G. Haasnoot, Jane M. L. Pieters

Publikováno v: European journal of biochemistry. 143(2)

The two deoxyribotetranucleoside triphosphates d(T-A-T-A) and d(A-T-A-T) were investigated in aqueous solution by one- and two-dimensional proton NMR at 300 and 500 MHz. It is demonstrated that both compounds occur predominantly in the single-helical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::338422efab1a35fbc3ce79dffb2e5143
https://pubmed.ncbi.nlm.nih.gov/6547907

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