Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Jan-Peter Sowa"'
Autor:
Christine March, Maximilian Thormann, Sarah Geipel, Jan-Peter Sowa, Felix Barajas Ordonez, Maciej Pech, Jazan Omari, Peter Lemmer
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Sarcopenia is common in patients with liver cirrhosis and related to higher mortality. Implantation of a transjugular intrahepatic portosystemic shunt (TIPS) is a feasible method for reducing cirrhosis-related portal hypertension, but also p
Externí odkaz:
https://doaj.org/article/2bbd5c9c9a3b4d7caddfa15d993c97c5
Autor:
Anna-Sophia Leven, Robert K. Gieseler, Martin Schlattjan, Thomas Schreiter, Marco Niedergethmann, Theodor Baars, Hideo A. Baba, Mustafa K. Özçürümez, Jan-Peter Sowa, Ali Canbay
Publikováno v:
Adipocyte, Vol 10, Iss 1, Pp 558-573 (2021)
The role of visceral white adipose tissue (vWAT) in the progression of non-alcoholic liver disease (NAFLD) with its sub entities non-alcoholic fatty liver and steatohepatitis (NAFL; NASH) is underinvestigated. We thus explored mechanisms of fibrosis
Externí odkaz:
https://doaj.org/article/845cd90359424267aa600f842a6842c3
Autor:
Theodor Baars, Jan-Peter Sowa, Ursula Neumann, Stefanie Hendricks, Mona Jinawy, Julia Kälsch, Guido Gerken, Tienush Rassaf, Dominik Heider, Ali Canbay
Publikováno v:
Archives of Medical Science, Vol 16, Iss 1, Pp 71-80 (2019)
Introduction Liver parameters are associated with cardiovascular disease risk and severity of stenosis. It is unclear whether liver parameters could predict the long-term outcome of patients after acute myocardial infarction (AMI). We performed an un
Externí odkaz:
https://doaj.org/article/08464551f1f64ee48708edfc6e9c22a9
Autor:
Joeri Lambrecht, Stefaan Verhulst, Inge Mannaerts, Jan-Peter Sowa, Jan Best, Ali Canbay, Hendrik Reynaert, Leo A. van Grunsven
Publikováno v:
EBioMedicine, Vol 43, Iss , Pp 501-512 (2019)
Background: Platelet Derived Growth Factor Receptor beta (PDGFRβ) has been associated to hepatic stellate cell activation and has been the target of multiple therapeutic studies. However, little is known concerning its use as a diagnostic agent. Met
Externí odkaz:
https://doaj.org/article/5f85e40af5a64303a768e25e13006a94
Autor:
Guillermo Mazzolini, Catalina Atorrasagasti, Agostina Onorato, Estanislao Peixoto, Martin Schlattjan, Jan-Peter Sowa, Svenja Sydor, Guido Gerken, Ali Canbay
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract Mechanisms that control progression from simple steatosis to steato-hepatitis and fibrosis in patients with non-alcoholic fatty liver disease (NAFLD) are unknown. SPARC, a secreted matricellular protein, is over-expressed in the liver under
Externí odkaz:
https://doaj.org/article/1c427a079f5b42e8bf090c1de65c88de
Autor:
Thomas Schreiter, Robert K. Gieseler, Ramiro Vílchez-Vargas, Ruy Jauregui, Jan-Peter Sowa, Susanne Klein-Scory, Ruth Broering, Roland S. Croner, Jürgen W. Treckmann, Alexander Link, Ali Canbay
Publikováno v:
Pharmaceutics, Vol 13, Iss 12, p 2009 (2021)
A transcriptome-wide analysis of human liver for demonstrating differences between young and old humans has not yet been performed. However, identifying major age-related alterations in hepatic gene expression may pinpoint ontogenetic shifts with imp
Externí odkaz:
https://doaj.org/article/e92bcc90299442c9aed68102b82fb9b0
Autor:
Clemens Schotten, Bastian Ostertag, Jan-Peter Sowa, Paul Manka, Lars P. Bechmann, Gudrun Hilgard, Claudio Marquardt, Marc Wichert, Hidenori Toyoda, Christian M. Lange, Ali Canbay, Philip Johnson, Heiner Wedemeyer, Jan Best
Publikováno v:
Pharmaceuticals, Vol 14, Iss 8, p 735 (2021)
Despite vaccination programs and direct antiviral treatments, the incidence of virus-related hepatocellular carcinoma (HCC) remains high, while ultrasound-based detection rates for early-stage HCC is continuously low. To address this insufficiency, w
Externí odkaz:
https://doaj.org/article/045468dca41d475ab6d9de7bf5362464
Autor:
Svenja Sydor, Paul Manka, Jan Best, Sami Jafoui, Jan-Peter Sowa, Miguel Eugenio Zoubek, Virginia Hernandez-Gea, Francisco Javier Cubero, Julia Kälsch, Diana Vetter, Maria Isabel Fiel, Yujin Hoshida, C. Billie Bian, Leonard J. Nelson, Han Moshage, Klaas Nico Faber, Andreas Paul, Hideo A. Baba, Guido Gerken, Scott L. Friedman, Ali Canbay, Lars P. Bechmann
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Krüppel-like factor 6 (KLF6) is a transcription factor and tumor suppressor. We previously identified KLF6 as mediator of hepatocyte glucose and lipid homeostasis. The loss or reduction of KLF6 is linked to the progression of hepatocellular
Externí odkaz:
https://doaj.org/article/2286249dec7344db8e423965de3b8b26
Autor:
Svenja Sydor, Jan-Peter Sowa, Dominik A. Megger, Martin Schlattjan, Sami Jafoui, Lena Wingerter, Alexander Carpinteiro, Hideo A. Baba, Lars P. Bechmann, Barbara Sitek, Guido Gerken, Erich Gulbins, Ali Canbay
Publikováno v:
Molecular Metabolism, Vol 6, Iss 5, Pp 416-427 (2017)
Objective: Alterations in sphingolipid and ceramide metabolism have been associated with various diseases, including nonalcoholic fatty liver disease (NAFLD). Acid sphingomyelinase (ASM) converts the membrane lipid sphingomyelin to ceramide, thereby
Externí odkaz:
https://doaj.org/article/d4b49d3c590246118696cbb458efdda9
Autor:
Ali Canbay, Julia Kälsch, Ursula Neumann, Monika Rau, Simon Hohenester, Hideo A Baba, Christian Rust, Andreas Geier, Dominik Heider, Jan-Peter Sowa
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0214436 (2019)
BACKGROUND & AIMS:Current non-invasive scores for the assessment of severity of non-alcoholic fatty liver disease (NAFLD) and identification of patients with non-alcoholic steatohepatitis (NASH) have insufficient performance to be included in clinica
Externí odkaz:
https://doaj.org/article/49e3a3f4ce94411c8eef5076c65c3771