Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jan-Peter H. T. M. Ploemen"'
Publikováno v:
Toxicologic Pathology. 35:834-837
Collection of toxicokinetic data has become a routine practice during the last 15 years in most general toxicity studies on pharma. It enables the correlation of pathological changes with the plasma concentration of drugs and/or their metabolites. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a7abc067ef6f53853c1b41dde2eb76e
https://doi.org/10.1080/01926230701584247
https://doi.org/10.1080/01926230701584247
Autor:
Carol Thijssen-van Zuylen, Willem G.E.J. Schoonen, Pieter Zandberg, Martin J. Smit, G. Jean Horbach, Joop H. J. van Nesselrooij, Jan-Remt Mellema, Jack T. W. E. Vogels, Albert C. Tas, Jan-Peter H. T. M. Ploemen, Cathelijne P. A. M. Kloks
Publikováno v:
Toxicological Sciences. 98:271-285
1H nuclear magnetic resonance (NMR) spectroscopy of rat urine in combination with pattern recognition analysis was evaluated for early noninvasive detection of toxicity of investigational chemical entities. Bromobenzene (B) and paracetamol (P) were a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdfc337fbdadb07e10ff359f447d8713
https://doi.org/10.1093/toxsci/kfm076
https://doi.org/10.1093/toxsci/kfm076
Autor:
Eric Van Esch, Jan-Peter H. T. M. Ploemen, Han van de Sandt, P. Salemink, Jan Kelder, Theo Hafmans, Johan A. van Burgsteden
Publikováno v:
Experimental and Toxicologic Pathology. 55:347-355
Several cationic amphiphilic compounds are known to induce phospholipidosis, a condition primarily characterized by excessive accumulation of phospholipids in different cell types, giving the affected cells a finely foamy appearance. Excessive storag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5db8617a6cf1a864fb5853dd749aa67
https://doi.org/10.1078/0940-2993-00338
https://doi.org/10.1078/0940-2993-00338
Publikováno v:
Toxicologic Pathology. 31:214-219
The incidence of thymic B cell lymphoid follicles was retrospectively studied in 62 male and 58 female healthy control beagle dogs (age 11.3 ± 4.8, range 6 to 23 months). The animals were selected from toxicological studies performed in the period 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd2174af4501f29c2f5fc085fafa556
https://doi.org/10.1080/01926230390183706
https://doi.org/10.1080/01926230390183706
Autor:
Eric Van Esch, Rotimi Oshodi, Wilbert J. A. M. Frieling, Jan-Peter H. T. M. Ploemen, Saskia C. M. de Hoog, Gerry Kaijser
Publikováno v:
Laboratory Animals. 36:181-187
To assess the tolerability of an acid vehicle to be used in toxicology studies, a low pH aqueous solution containing 16.4 mg/ml of citric acid, 4.2 mg/ml of disodium phosphate, 25 mg/ml of mannitol, adjusted with phosphoric acid/NaOH 1 M to pH 3 was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d0b41d6d69b2cd11a44147fbd3ab4c0
https://doi.org/10.1258/0023677021912325
https://doi.org/10.1258/0023677021912325
Autor:
Jan-Peter H. T. M. Ploemen, L. P. C. Delbressine, Denis M. Bayada, Jan Kelder, Peter D. J. Grootenhuis
Publikováno v:
Pharmaceutical Research. 16:1514-1519
Purpose. To study oral absorption and brain penetration as a function of polar molecular surface area.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdd4ca86b763e04f9bf88378ec244779
https://doi.org/10.1023/a:1015040217741
https://doi.org/10.1023/a:1015040217741
Autor:
Martin J. Smit, G. Jean Horbach, Jan-Peter H. T. M. Ploemen, Willem G.E.J. Schoonen, Pieter Zandberg, Cathelijne P. A. M. Kloks, Jack T. W. E. Vogels, Albert C. Tas, Jan-Remt Mellema, Joop H. J. van Nesselrooij, Carol Thijssen-vanZuylen
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 98(1)
A procedure of nuclear magnetic resonance (NMR) urinalysis using pattern recognition is proposed for early detection of toxicity of investigational compounds in rats. The method is applied to detect toxicity upon administration of 13 toxic reference
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51cc67d7b7e9bcea3ef8be7d01ca589b
https://pubmed.ncbi.nlm.nih.gov/17420222
https://pubmed.ncbi.nlm.nih.gov/17420222
Autor:
Jan-Peter H T M, Ploemen, Jan, Kelder, Theo, Hafmans, Han, van de Sandt, Johan A, van Burgsteden, Paul J M, Saleminki, Eric, van Esch
Publikováno v:
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 55(5)
Several cationic amphiphilic compounds are known to induce phospholipidosis, a condition primarily characterized by excessive accumulation of phospholipids in different cell types, giving the affected cells a finely foamy appearance. Excessive storag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::52a3e62821acf805f23458ea31179dcf
https://pubmed.ncbi.nlm.nih.gov/15088636
https://pubmed.ncbi.nlm.nih.gov/15088636
Autor:
Willem G. E. J. Schoonen, Cathelijne P. A. M. Kloks, Jan-Peter H. T. M. Ploemen, Martin J. Smit, Pieter Zandberg, G. Jean Horbach, Jan-Remt Mellema, Carol Thijssen-vanZuylen, Albert C. Tas, Joop H. J. van Nesselrooij, Jack T. W. E. Vogels
Publikováno v:
Toxicological Sciences; Jul2007, Vol. 98 Issue 1, p286-286, 1p
Autor:
Willem G. E. J. Schoonen, Cathelijne P. A. M. Kloks, Jan-Peter H. T. M. Ploemen, G. Jean Horbach, Martin J. Smit, Pieter Zandberg, Jan-Remt Mellema, Carol Thijssen-van Zuylen, Albert C. Tas, Joop H. J. van Nesselrooij, Jack T. W. E. Vogels
Publikováno v:
Toxicological Sciences; Jul2007, Vol. 98 Issue 1, p271-271, 1p