Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Jan-Kan Chen"'
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1, p 46 (2021)
The pluripotent transcription factor NANOG is essential for maintaining embryonic stem cells and driving tumorigenesis. We previously showed that PKC activity is involved in the regulation of NANOG expression. To explore the possible involvement of m
Externí odkaz:
https://doaj.org/article/e8071bac95f8430aa31150961d571c3d
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 2, p 694 (2021)
The Yes-associated protein (YAP) is a transcriptional co-activator that plays critical roles in organ development and tumorigenesis, and is verified to be inhibited by the Hippo signaling pathway. In the present study, we show that the YAP 3′UTR is
Externí odkaz:
https://doaj.org/article/86e4a2b05be346ca88a0760ed4ae7514
Publikováno v:
Journal of Functional Foods, Vol 18, Iss , Pp 737-745 (2015)
Resveratrol (RSV) is a natural polyphenol that exerts anti-diabetic effects. The present study was aimed to elucidate the effects of RSV treatment on type 1 diabetes mellitus (DM) induced metabolic disorders in rats. Streptozotocin (STZ) induced type
Externí odkaz:
https://doaj.org/article/c40a41ff2be94e7dbe85795acf6690b3
Autor:
Song-Shu Lin, Steve W.N. Ueng, Chi-Chien Niu, Li-Jen Yuan, Chuen-Yung Yang, Wen-Jer Chen, Mel S. Lee, Jan-Kan Chen
Publikováno v:
Stem Cell Research, Vol 12, Iss 1, Pp 260-274 (2014)
We hypothesized that the effect of hyperbaric oxygen (HBO) on bone formation is increased via osteogenic differentiation of bone marrow stromal cells (BMSCs), which is regulated by Wnt3a/β-catenin signaling. Our in vitro data showed that HBO increas
Externí odkaz:
https://doaj.org/article/4c3a75ca075e4935b11e2c85e1c75fac
Autor:
Jeng-Yuan Yao, Jan-Kan Chen
Publikováno v:
Biomedical Journal, Vol 35, Iss 6, Pp 457-463 (2012)
pidermis is composed mainly of keratinocytes and is the major barrier of human body. The development and maintenance of normal epithelial structures and functions require the transcription factor p63. The p63 gene encodes proteins with structures
Externí odkaz:
https://doaj.org/article/60a59ab7da5f4f08b3e8493b370cfc28
Autor:
Kuan-Hsing Chen, Yi-Ling Chen, Hsiang-Yu Tang, Cheng-Chieh Hung, Tzung-Hai Yen, Mei-Ling Cheng, Ming-Shi Shiao, Jan-Kan Chen
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 7, p 1921 (2018)
Dietary leucine supplementation has been explored for the therapeutic intervention of obesity and obesity-induced metabolic dysfunctions. In this study, we aim to examine the effects of dietary leucine supplementation in db/db mice. Mice were treated
Externí odkaz:
https://doaj.org/article/331d4f5b835f490993e84ae00cf38b6b
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 2, Iss , Pp - (2015)
The first two authors contributed equally to this work.Silence of p120-catenin has shown promise in inducing proliferation in human corneal endothelial cells (HCECs), but there is concern regarding off-target effects in potential clinical application
Externí odkaz:
https://doaj.org/article/8c47adf8ecb64758beb38eb9284872cb
Autor:
Fu-Ying Lee, Demei Lee, Tzu-Chia Lee, Jan-Kan Chen, Ren-Chin Wu, Kuan-Chieh Liu, Shih-Jung Liu
Publikováno v:
Polymers, Vol 9, Iss 9, p 416 (2017)
This study developed multi-layered lidocaine- and epinephrine-eluting biodegradable poly[(d,l)-lactide-co-glyco lide] (PLGA)/collagen nanofibers. An electrospinning technique was employed to fabricate the multi-layer biodegradable drug-eluting nanofi
Externí odkaz:
https://doaj.org/article/e988dfe2b92e427f847ffe437f369230
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 46, p 46 (2022)
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 46
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 46
International Journal of Molecular Sciences
The pluripotent transcription factor NANOG is essential for maintaining embryonic stem cells and driving tumorigenesis. We previously showed that PKC activity is involved in the regulation of NANOG expression. To explore the possible involvement of m
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1862:12-24
The Yes-associated protein (YAP) is a transcription coactivator that plays crucial roles in organ size control and tumorigenesis, and was demonstrated to be inhibited by the Hippo signaling pathway. To date, the molecular mechanisms regulating the ex