Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Jan-Ingvar Jönsson"'
Autor:
Emma Rörby, Jörgen Adolfsson, Erik Hultin, Thomas Gustafsson, Kourosh Lotfi, Jörg Cammenga, Jan-Ingvar Jönsson
Publikováno v:
Experimental Hematology & Oncology, Vol 10, Iss 1, Pp 1-14 (2021)
Abstract Background Fms-related tyrosine kinase 3 (FLT3) receptor serves as a prognostic marker and therapeutic target in acute myeloid leukemia (AML). Approximately one-third of AML patients carry mutation in FLT3, associated with unfavourable progn
Externí odkaz:
https://doaj.org/article/1dba84575ec44799a51953ec59e38b1b
Publikováno v:
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-4 (2020)
Abstract This commentary presents the vision of the International Consortium for Personalised Medicine (ICPerMed) on how personalised medicine (PM) will lead to the next generation of healthcare by 2030. This vision focuses on five perspectives: indi
Externí odkaz:
https://doaj.org/article/a078a54056654f17b0480118f196d700
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171714 (2017)
BACKGROUND:Accumulating evidence suggests that hypoxic areas in the bone marrow are crucial for maintenance of hematopoietic stem cells (HSCs) by supporting a quiescent state of cell cycle and regulating the transplantation capacity of long-term (LT)
Externí odkaz:
https://doaj.org/article/5afbb05bdf5f425e993835e0fea63089
Autor:
Deepti Verma, Eva Särndahl, Henrik Andersson, Per Eriksson, Mats Fredrikson, Jan-Ingvar Jönsson, Maria Lerm, Peter Söderkvist
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34977 (2012)
The Q705K polymorphism in NLRP3 has been implicated in several chronic inflammatory diseases. In this study we determine the functional role of this commonly occurring polymorphism using an in-vitro system.NLRP3-WT and NLRP3-Q705K were retrovirally t
Externí odkaz:
https://doaj.org/article/1d9ac372a87f4746af8fcb763333518e
Autor:
Klara Martinsson, Thomas Skogh, Seyed Ali Mousavi, Trond Berg, Jan-Ingvar Jönsson, Per Hultman
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13413 (2010)
BACKGROUND: Inorganic mercury (Hg) induces a T-cell dependent, systemic autoimmune condition (HgIA) where activating Fcγ-receptors (FcγRs) are important for the induction. In this study we examined the influence of activating FcγRs on circulating
Externí odkaz:
https://doaj.org/article/d1e1f9a0f7304cb29ffc1de5ca11d944
Autor:
Kourosh Lotfi, Jörgen Adolfsson, Jörg Cammenga, Emma Rörby, Thomas Gustafsson, Jan-Ingvar Jönsson, Erik Hultin
Publikováno v:
Experimental Hematology & Oncology, Vol 10, Iss 1, Pp 1-14 (2021)
Experimental Hematology & Oncology
Experimental Hematology & Oncology
Background Fms-related tyrosine kinase 3 (FLT3) receptor serves as a prognostic marker and therapeutic target in acute myeloid leukemia (AML). Approximately one-third of AML patients carry mutation in FLT3, associated with unfavourable prognosis and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8cccda456952ff75f0bfbef98b97407
https://doaj.org/article/1dba84575ec44799a51953ec59e38b1b
https://doaj.org/article/1dba84575ec44799a51953ec59e38b1b
Autor:
Zengren Zhao, Jie Ping, Lasse Jensen, Xia Jiang, Sebastian Gnosa, Zhi-Yong Zhang, Xiao-Feng Sun, Jan-Ingvar Jönsson, Weiyingqi Cui, Eric Lam, Na Liu, Zaheer Ali, Xin Wang, Stéphanie Blockhuys, Maria Kopsida, Ning Xie
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 104:1153-1164
Purpose To explore whether the Rho protein is involved in the radioresistance of colorectal cancer and investigate the underlying mechanisms. Methods and Materials Rho GTPase expression was measured after radiation treatment in colon cancer cells. Rh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda0c310a4f1615a8adf5a973b7a542d
https://doi.org/10.1016/j.ijrobp.2019.04.021
https://doi.org/10.1016/j.ijrobp.2019.04.021
Hematopoietic stem cells are used in transplantations for patients with hematologic malignancies. Scarce sources require efficient strategies of expansion, including polymeric biomaterials mimicking architectures of bone marrow tissue. Tissue microen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4f8d3a00a3fb729ef5cf6cadd802c04
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-160752
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-160752
Autor:
Yanjuan Tang, Josefine Åhsberg, Camilla Halvarsson, Wan Man Wong, Jan-Ingvar Jönsson, Amanda Nordigården, Emma Rörby, Komal Kumar
Publikováno v:
Experimental Hematology. 43:554-564
The phosphatidylinositol 3-kinase/AKT pathway is an integral component of signaling involved in the development of many cancers, including myeloid leukemias such as chronic myeloid leukemia and acute myeloid leukemia (AML). Increased AKT1 activity is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78856ce9ef5c5eaf41dc4a4c175b8ff9
https://doi.org/10.1016/j.exphem.2015.04.007
https://doi.org/10.1016/j.exphem.2015.04.007
Publikováno v:
International Journal of Molecular Sciences; Volume 18; Issue 5; Pages: 943
Despite advances in the head and neck squamous cell carcinoma (HNSCC) treatment modalities, drug resistance and cancer recurrence are often reported. Hypoxia signaling through hypoxia-inducible factor 1 (HIF-1) promotes angiogenesis and metastasis by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::9be6b00a272885140319e29746a6c6b7