Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jan-Gert Brüning"'
Autor:
Jan-Gert Brüning, Kenneth J. Marians
Publikováno v:
Nucleic Acids Research
The vast majority of the genome is transcribed by RNA polymerases. G+C-rich regions of the chromosomes and negative superhelicity can promote the invasion of the DNA by RNA to form R-loops, which have been shown to block DNA replication and promote g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06773067a4c7e6b9637c92e6f4bc0fad
http://europepmc.org/articles/PMC7544221
http://europepmc.org/articles/PMC7544221
Autor:
Jan-Gert Brüning, Kenneth J. Marians
Publikováno v:
Nucleic Acids Research
Collisions between the replisome and RNA polymerases [RNAP(s)] are the main obstacle to DNA replication. These collisions can occur either head-on or co-directionally with respect to the direction of translocation of both complexes. Whereas head-on c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4d88a1b46109b86412ed89b2a19046f
https://pubmed.ncbi.nlm.nih.gov/34469567
https://pubmed.ncbi.nlm.nih.gov/34469567
Autor:
Aisha H, Syeda, Adam J M, Wollman, Alex L, Hargreaves, Jamieson A L, Howard, Jan-Gert, Brüning, Peter, McGlynn, Mark C, Leake
Publikováno v:
Nucleic Acids Research
DNA replication must cope with nucleoprotein barriers that impair efficient replisome translocation. Biochemical and genetic studies indicate accessory helicases play essential roles in replication in the presence of nucleoprotein barriers, but how t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::095fdcd8c3ad72350788de4389f70bae
https://pubmed.ncbi.nlm.nih.gov/31028385
https://pubmed.ncbi.nlm.nih.gov/31028385
Publikováno v:
Journal of Molecular Biology
Replicative helicases play central roles in chromosome duplication and their assembly onto DNA is regulated via initiators and helicase loader proteins. The Escherichia coli replicative helicase DnaB and the helicase loader DnaC form a DnaB6–DnaC6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c779829d20ca517bbf282e706790d0b2
Publikováno v:
Brüning, J G, Howard, J A L, Myka, K K, Dillingham, M S & McGlynn, P 2018, ' The 2B subdomain of Rep helicase links translocation along DNA with protein displacement ', Nucleic Acids Research, vol. 46, no. 17, gky673, pp. 8917-8925 . https://doi.org/10.1093/nar/gky673
Nucleic Acids Research
Nucleic Acids Research
Helicases catalyse DNA and RNA strand separation. Proteins bound to the nucleic acid must also be displaced in order to unwind DNA. This is exemplified by accessory helicases that clear protein barriers from DNA ahead of advancing replication forks.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19581e64547e68749ba9dda280270099
https://hdl.handle.net/1983/d3620190-3208-47f0-b925-db5f7c7cbcb4
https://hdl.handle.net/1983/d3620190-3208-47f0-b925-db5f7c7cbcb4
Publikováno v:
Journal of Molecular Biology. 426:3917-3928
Complete, accurate duplication of the genetic material is a prerequisite for successful cell division. Achieving this accuracy is challenging since there are many barriers to replication forks that may cause failure to complete genome duplication or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ef220dc8ac96d351e75cd57e76c9552
https://doi.org/10.1016/j.jmb.2014.10.001
https://doi.org/10.1016/j.jmb.2014.10.001
Publikováno v:
Methods (San Diego, Calif.). 108
Helicases are a subfamily of translocases that couple the directional translocation along a nucleic acid lattice to the separation of nucleic acid duplexes using the energy derived from nucleoside triphosphate hydrolysis. These enzymes perform essent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3c529737719ebf8a665c8e881fa7f5ff
https://pubmed.ncbi.nlm.nih.gov/27017910
https://pubmed.ncbi.nlm.nih.gov/27017910