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pro vyhledávání: '"Jan-Eric Boekenkamp"'
Autor:
Maik Kschischo, Ann-Kathrin Schmidt, Holger Bastians, Jan-Eric Boekenkamp, Karoline Pudelko, Katharina Berger
Publikováno v:
Oncogene
Whole chromosome instability (W-CIN) is a hallmark of human cancer and contributes to the evolvement of aneuploidy. W-CIN can be induced by abnormally increased microtubule plus end assembly rates during mitosis leading to the generation of lagging c
Autor:
Sara Vanessa Bernhard, Katarzyna Seget-Trzensiok, Christian Kuffer, Dragomir B. Krastev, Lisa-Marie Stautmeister, Mirko Theis, Kristina Keuper, Jan-Eric Boekenkamp, Maik Kschischo, Frank Buchholz, Zuzana Storchova
Publikováno v:
Cellular oncology
Background Whole genome doubling is a frequent event during cancer evolution and shapes the cancer genome due to the occurrence of chromosomal instability. Yet, erroneously arising human tetraploid cells usually do not proliferate due to p53 activati
Autor:
Jan-Eric Boekenkamp, Mirko Theis, Katarzyna Seget-Trzensiok, Zuzana Storchova, Dragomir B Krastev, Kristina Keuper, Sara Vanessa Bernhard, Maik Kschischo, Frank Buchholz, Christian Kuffer
Tetraploidy is frequent in cancer and whole genome doubling shapes the evolution of cancer genomes, thereby driving the transformation, metastasis and drug resistance. Yet, human cells usually arrest when they become tetraploid due to p53 activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36a59eb486d17b90494b58378a5fe902
https://doi.org/10.1101/2020.09.18.303834
https://doi.org/10.1101/2020.09.18.303834