Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jan-David Nicolas"'
Autor:
Jan-David Nicolas, Marten Bernhardt, Karl Toischer, Marius Reichardt, Tim Salditt, Charlotte Neuhaus
Publikováno v:
Biophysical journal 119(7), 1309-1323 (2020). doi:10.1016/j.bpj.2020.08.019
Biophysical Journal
Biophysical Journal
We present a multiscale imaging approach to characterize the structure of isolated adult murine cardiomyocytes based on a combination of full-field three-dimensional coherent x-ray imaging and scanning x-ray diffraction. Using these modalities, we pr
Autor:
Tim Salditt, Susanne F. Schlick, Amara Khan, Malte Tiburcy, Karl Toischer, Frauke Alves, Jan-David Nicolas, Marten Bernhardt, Andrea Markus, Wolfram-Hubertus Zimmermann
Publikováno v:
Progress in biophysics & molecular biology 144, 151-165 (2019). doi:10.1016/j.pbiomolbio.2018.05.012
With the development of advanced focusing optics for x-rays, we can now use x-ray beams with spot sizes in the micro- or nanometer range to scan cells and large areas of tissues and continuously record the diffraction signals. From this data, x-ray s
Autor:
Karina, Joppe, Jan-David, Nicolas, Tilman A, Grünewald, Marina, Eckermann, Tim, Salditt, Paul, Lingor
Publikováno v:
Biomed Opt Express
In this work we use scanning X-ray microscopy to study the structure and elemental composition of neuromelanin-positive neurons in substantia nigra tissue of Parkinson patients (PD) and controls. A total of 53 neurons were analyzed with X-ray fluores
Autor:
H. Mittelstadt, Michael Sprung, Tim Salditt, Marten Bernhardt, Sarah Köster, Markus Osterhoff, Andrew Wittmeier, Benjamin Harke, Jan-David Nicolas, Matthias Reuss
Publikováno v:
Microscopy and Microanalysis. 24:64-67
Publikováno v:
Journal of Synchrotron Radiation. 25:1196-1205
For almost half a century, optical tweezers have successfully been used to micromanipulate micrometre and sub-micrometre-sized particles. However, in recent years it has been shown experimentally that, compared with single-beam traps, the use of two
Autor:
Tim Salditt, Jan-David Nicolas, Frauke Alves, Manfred Burghammer, M. Andrea Markus, Marten Bernhardt
Publikováno v:
Journal of Synchrotron Radiation. 24:1163-1172
A scanning X-ray diffraction study of cardiac tissue has been performed, covering the entire cross section of a mouse heart slice. To this end, moderate focusing by compound refractive lenses to micrometer spot size, continuous scanning, data acquisi
Autor:
Martin Krenkel, Stefan Luther, Marten Bernhardt, Claudia Richter, Jan-David Nicolas, Tim Salditt
Publikováno v:
Journal of Applied Crystallography. 50:612-620
This article presents scanning small-angle X-ray scattering (SAXS) experiments on the actomyosin assemblies in freeze-dried neo-natal rat cardiac muscle cells. By scanning the cells through a sub-micrometre focused beam, the local structure and filam
Publikováno v:
Journal of synchrotron radiation 26(4), 980-990 (2019). doi:10.1107/S1600577519006817
Soft materials are easily affected by radiation damage from intense, focused synchrotron beams, often limiting the use of scanning diffraction experiments to radiation-resistant samples. To minimize radiation damage in experiments on soft tissue and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1404ed6883dd713756ceabd07e7ab9ee
https://bib-pubdb1.desy.de/record/435027
https://bib-pubdb1.desy.de/record/435027
Autor:
Jan-David Nicolas
Publikováno v:
Göttingen Series in x-ray Physics ISBN: 9783863954208
The past 70 years of muscle research have profoundly shaped our current understanding of the structure and function of muscle. X-ray diffraction became a key method in its structural analysis and yielded valuable insights into the molecular arrangeme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d71166231801147eba9b9a38187aef4
https://doi.org/10.17875/gup2019-1178
https://doi.org/10.17875/gup2019-1178
Autor:
Haugen Mittelstädt, Tim Salditt, Michael Sprung, Markus Osterhoff, Sarah Köster, Andrew Wittmeier, Matthias Reuss, Benjamin Harke, Jan David Nicolas, Marten Bernhardt
Publikováno v:
Journal of synchrotron radiation. 26(Pt 4)
A dedicated stimulated emission depletion (STED) microscope had been designed and implemented into the Göttingen Instrument for Nano-Imaging with X-rays (GINIX) at the synchrotron beamline P10 of the PETRA III storage ring (DESY, Hamburg). The micro