Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Jan-David Nicolas"'
Autor:
Jan-David Nicolas, Marten Bernhardt, Karl Toischer, Marius Reichardt, Tim Salditt, Charlotte Neuhaus
Publikováno v:
Biophysical journal 119(7), 1309-1323 (2020). doi:10.1016/j.bpj.2020.08.019
Biophysical Journal
Biophysical Journal
We present a multiscale imaging approach to characterize the structure of isolated adult murine cardiomyocytes based on a combination of full-field three-dimensional coherent x-ray imaging and scanning x-ray diffraction. Using these modalities, we pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87e36f9e25a39fcf8936d9478caddb84
https://doi.org/10.1016/j.bpj.2020.08.019
https://doi.org/10.1016/j.bpj.2020.08.019
Autor:
Tim Salditt, Susanne F. Schlick, Amara Khan, Malte Tiburcy, Karl Toischer, Frauke Alves, Jan-David Nicolas, Marten Bernhardt, Andrea Markus, Wolfram-Hubertus Zimmermann
Publikováno v:
Progress in biophysics & molecular biology 144, 151-165 (2019). doi:10.1016/j.pbiomolbio.2018.05.012
With the development of advanced focusing optics for x-rays, we can now use x-ray beams with spot sizes in the micro- or nanometer range to scan cells and large areas of tissues and continuously record the diffraction signals. From this data, x-ray s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c69411753758aacf7c06bd8a395a4c80
https://doi.org/10.1016/j.pbiomolbio.2018.05.012
https://doi.org/10.1016/j.pbiomolbio.2018.05.012
Autor:
Karina, Joppe, Jan-David, Nicolas, Tilman A, Grünewald, Marina, Eckermann, Tim, Salditt, Paul, Lingor
Publikováno v:
Biomed Opt Express
In this work we use scanning X-ray microscopy to study the structure and elemental composition of neuromelanin-positive neurons in substantia nigra tissue of Parkinson patients (PD) and controls. A total of 53 neurons were analyzed with X-ray fluores
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::602811621756c7415afea9c824b94f83
https://pubmed.ncbi.nlm.nih.gov/33014542
https://pubmed.ncbi.nlm.nih.gov/33014542
Autor:
H. Mittelstadt, Michael Sprung, Tim Salditt, Marten Bernhardt, Sarah Köster, Markus Osterhoff, Andrew Wittmeier, Benjamin Harke, Jan-David Nicolas, Matthias Reuss
Publikováno v:
Microscopy and Microanalysis. 24:64-67
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb6eb0d7f056e73c2c72a20f7c3ef7c3
https://doi.org/10.1017/s1431927618012734
https://doi.org/10.1017/s1431927618012734
Publikováno v:
Journal of Synchrotron Radiation. 25:1196-1205
For almost half a century, optical tweezers have successfully been used to micromanipulate micrometre and sub-micrometre-sized particles. However, in recent years it has been shown experimentally that, compared with single-beam traps, the use of two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04ff83413b21907f17903093cce66392
https://doi.org/10.1107/s1600577518006574
https://doi.org/10.1107/s1600577518006574
Autor:
Tim Salditt, Jan-David Nicolas, Frauke Alves, Manfred Burghammer, M. Andrea Markus, Marten Bernhardt
Publikováno v:
Journal of Synchrotron Radiation. 24:1163-1172
A scanning X-ray diffraction study of cardiac tissue has been performed, covering the entire cross section of a mouse heart slice. To this end, moderate focusing by compound refractive lenses to micrometer spot size, continuous scanning, data acquisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd744f3327ce97195ab9b4a08b223e50
https://doi.org/10.1107/s1600577517011936
https://doi.org/10.1107/s1600577517011936
Autor:
Martin Krenkel, Stefan Luther, Marten Bernhardt, Claudia Richter, Jan-David Nicolas, Tim Salditt
Publikováno v:
Journal of Applied Crystallography. 50:612-620
This article presents scanning small-angle X-ray scattering (SAXS) experiments on the actomyosin assemblies in freeze-dried neo-natal rat cardiac muscle cells. By scanning the cells through a sub-micrometre focused beam, the local structure and filam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4185a575e14cf2fe5455a7ed455b825
https://doi.org/10.1107/s1600576717003351
https://doi.org/10.1107/s1600576717003351
Publikováno v:
Journal of synchrotron radiation 26(4), 980-990 (2019). doi:10.1107/S1600577519006817
Soft materials are easily affected by radiation damage from intense, focused synchrotron beams, often limiting the use of scanning diffraction experiments to radiation-resistant samples. To minimize radiation damage in experiments on soft tissue and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1404ed6883dd713756ceabd07e7ab9ee
https://bib-pubdb1.desy.de/record/435027
https://bib-pubdb1.desy.de/record/435027
Autor:
Jan-David Nicolas
Publikováno v:
Göttingen Series in x-ray Physics ISBN: 9783863954208
The past 70 years of muscle research have profoundly shaped our current understanding of the structure and function of muscle. X-ray diffraction became a key method in its structural analysis and yielded valuable insights into the molecular arrangeme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d71166231801147eba9b9a38187aef4
https://doi.org/10.17875/gup2019-1178
https://doi.org/10.17875/gup2019-1178
Autor:
Jan-David Nicolas, Amara Khan, Andrea Markus, Belal A. Mohamed, Karl Toischer, Frauke Alves, Tim Salditt
Publikováno v:
'Scientific Reports ', vol: 10, pages: 19317-1-19317-15 (2020)
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
We demonstrate a label-free imaging approach to study cardiac remodeling of fibrotic and hypertrophic hearts, bridging scales from the whole organ down to the molecular level. To this end, we have used mice subjected to transverse aortic constriction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e533a28bdd6ea60e18ad4f42e3571ce0
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:57144
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:57144