Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jan van der Schueren"'
Autor:
Maarten Gees, Sara Musch, Steven Van der Plas, Anne-Sophie Wesse, Ann Vandevelde, Katleen Verdonck, Oscar Mammoliti, Tzyh-Chang Hwang, Kathleen Sonck, Pieter Stouten, Andrew M. Swensen, Mia Jans, Jan Van der Schueren, Luc Nelles, Martin Andrews, Katja Conrath
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
There is still a high unmet need for the treatment of most patients with cystic fibrosis (CF). The identification and development of new Cystic Fibrosis Transmembrane conductance Regulator (CFTR) modulators is necessary to achieve higher clinical ben
Externí odkaz:
https://doaj.org/article/99852fe337bc4182a943b73d103f71f5
Autor:
Sebastien Dropsit, Pieter F. W. Stouten, Linda Tomaskovic, Thierry Christophe, Ellen van der Aar, Maarten Gees, Luc Nelles, Mia Jans, Monica Borgonovi, Evelyne M. Quinton, Katja Conrath, Jan Van Der Schueren, Caroline Joannesse, Hans Kelgtermans, Martin James Inglis Andrews, Sebastien Laurent Xavier Martina, Oscar Mammoliti, Ann De Blieck, Steven Emiel Van Der Plas, Tom De Munck
Publikováno v:
Journal of Medicinal Chemistry. 61:1425-1435
Cystic fibrosis (CF) is caused by mutations in the gene for the cystic fibrosis transmembrane conductance regulator (CFTR). With the discovery of Ivacaftor and Orkambi, it has been shown that CFTR function can be partially restored by administering o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc1598dc3e22fb401aa0908c21814b75
https://doi.org/10.1021/acs.jmedchem.7b01288
https://doi.org/10.1021/acs.jmedchem.7b01288
Autor:
Kathleen Sonck, Mia Jans, Katja Conrath, Ann Vandevelde, Andrew M. Swensen, Pieter F. W. Stouten, Oscar Mammoliti, Maarten Gees, Katleen Verdonck, Steven Emiel Van Der Plas, Anne Sophie Wesse, Jan Van Der Schueren, Luc Nelles, Martin James Inglis Andrews, Sara Musch, Tzyh Chang Hwang
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Frontiers in Pharmacology
Frontiers in Pharmacology
There is still a high unmet need for the treatment of most patients with cystic fibrosis (CF). The identification and development of new Cystic Fibrosis Transmembrane conductance Regulator (CFTR) modulators is necessary to achieve higher clinical ben
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fee33c28983985798adc777f3acffec6
https://www.frontiersin.org/article/10.3389/fphar.2018.01221/full
https://www.frontiersin.org/article/10.3389/fphar.2018.01221/full
Autor:
Steven E, Van der Plas, Hans, Kelgtermans, Tom, De Munck, Sébastien L X, Martina, Sébastien, Dropsit, Evelyne, Quinton, Ann, De Blieck, Caroline, Joannesse, Linda, Tomaskovic, Mia, Jans, Thierry, Christophe, Ellen, van der Aar, Monica, Borgonovi, Luc, Nelles, Maarten, Gees, Pieter, Stouten, Jan, Van Der Schueren, Oscar, Mammoliti, Katja, Conrath, Martin, Andrews
Publikováno v:
Journal of medicinal chemistry. 61(4)
Cystic fibrosis (CF) is caused by mutations in the gene for the cystic fibrosis transmembrane conductance regulator (CFTR). With the discovery of Ivacaftor and Orkambi, it has been shown that CFTR function can be partially restored by administering o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::528097bcdc809fb179a6c30494225cb7
https://pubmed.ncbi.nlm.nih.gov/29148763
https://pubmed.ncbi.nlm.nih.gov/29148763
Autor:
Mark Jacques Yvonne Lambrecht, Emir Mesic, Remko Johannes Clasen, Rudi Tissingh, Kim Thys, Peter Herwig Maria Tomme, Heidi Pavliska, Marcel Hoffmann, Libin Ma, Gert-Jan Arts, Kristina Dokic, Jan van der Schueren, Helmuth van Es, Sofie Herman, Frits Michiels, Richele Dooijes, Ellen Langemeijer, Reginald Christophe Xavier Brys
Publikováno v:
Genome Research. 13:2325-2332
RNA interference is a powerful tool for studying gene function and for drug target discovery in diverse organisms and cell types. In mammalian systems, small interfering RNAs (siRNAs), or DNA plasmids expressing these siRNAs, have been used to down-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b92c3f60af4ced0c083c5478d6b4ed49
https://doi.org/10.1101/gr.1332603
https://doi.org/10.1101/gr.1332603
Autor:
Frits, Michiels, Helmuth, van Es, Luc, van Rompaey, Pascal, Merchiers, Bart, Francken, Karen, Pittois, Jan, van der Schueren, Reginald, Brys, Johan, Vandersmissen, Filip, Beirinckx, Sofie, Herman, Kristina, Dokic, Hugo, Klaassen, Evi, Narinx, Annick, Hagers, Wendy, Laenen, Ivo, Piest, Heidi, Pavliska, Yvonne, Rombout, Ellen, Langemeijer, Libin, Ma, Christel, Schipper, Marc De, Raeymaeker, Stephane, Schweicher, Mia, Jans, Kris, van Beeck, Ing-Ren, Tsang, Onno, van de Stolpe, Peter, Tomme, Gert-Jan, Arts, Joost, Donker
Publikováno v:
Nature Biotechnology. 20:1154-1157
With the publication of the sequence of the human genome, we are challenged to identify the functions of an estimated 70,000 human genes1,2 and the much larger number of proteins encoded by these genes. Of particular interest is the identification of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c39165a7d768f6df3f64cf7c9dd4731
https://doi.org/10.1038/nbt746
https://doi.org/10.1038/nbt746
Autor:
Jacqueline Vander Stappen, Guido Volckaert, Elisabeth Vanstreels, Maria-Helena Voet, Jan Van der Schueren, Johan Robben
Publikováno v:
Yeast (Chichester, England). 20(1)
We describe the generation of null-mutants of 12 open reading frames (ORFs), discovered during the systematic sequencing of the Saccharomyces cerevisiae genome. These ORFs are located on chromosome IV (YDL183c), on chromosome VII (YGL139w, YGL140c, Y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c5a3e94f504fb09c444ca3629c4cd8c
https://pubmed.ncbi.nlm.nih.gov/12489128
https://pubmed.ncbi.nlm.nih.gov/12489128
Autor:
Ing-Ren Tsang, Karen Pittois, Peter Herwig Maria Tomme, Stephane Schweicher, Luc Van Rompaey, Libin Ma, Hugo Klaassen, Filip Beirinckx, Sofie Herman, Heidi Pavliska, Helmuth van Es, Bart Francken, Pascal Gerard Merchiers, Christel Schipper, Johan Vandersmissen, Marc De Raeymaeker, Wendy Laenen, Onno van de Stolpe, Annick Hagers, Mia Jans, Reginald Brys, Frits Michiels, Kris Van Beeck, Ivo Piest, Ellen Langemeijer, Yvonne Rombout, Kristina Dokic, Evi Narinx, Jan van der Schueren
Publikováno v:
Nature Biotechnology. 21:199-199
Nat. Biotechnol. 20, 1154–1157 (2002). Gert-Jan Arts and Joost Donker were inadvertently omitted from the list of authors when this report was submitted for publication. The authors regret the omission.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af716b23f655713eb6076b6a313ae653
https://doi.org/10.1038/nbt0203-199a
https://doi.org/10.1038/nbt0203-199a