Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jan van Ooyen"'
Autor:
Angela Kranz, Tino Polen, Christian Kotulla, Annette Arndt, Graziella Bosco, Michael Bussmann, Ava Chattopadhyay, Annette Cramer, Cedric-Farhad Davoudi, Ursula Degner, Ramon Diesveld, Raphael Freiherr von Boeselager, Kim Gärtner, Cornelia Gätgens, Tobias Georgi, Christian Geraths, Sabine Haas, Antonia Heyer, Max Hünnefeld, Takeru Ishige, Armin Kabus, Nicolai Kallscheuer, Larissa Kever, Simon Klaffl, Britta Kleine, Martina Kočan, Abigail Koch-Koerfges, Kim J. Kraxner, Andreas Krug, Aileen Krüger, Andreas Küberl, Mohamed Labib, Christian Lange, Christina Mack, Tomoya Maeda, Regina Mahr, Stephan Majda, Andrea Michel, Xenia Morosov, Olga Müller, Arun M. Nanda, Jens Nickel, Jennifer Pahlke, Eugen Pfeifer, Laura Platzen, Paul Ramp, Doris Rittmann, Steffen Schaffer, Sandra Scheele, Stephanie Spelberg, Julia Schulte, Jens-Eric Schweitzer, Georg Sindelar, Ulrike Sorger-Herrmann, Markus Spelberg, Corinna Stansen, Apilaasha Tharmasothirajan, Jan van Ooyen, Philana van Summeren-Wesenhagen, Michael Vogt, Sabrina Witthoff, Lingfeng Zhu, Bernhard J. Eikmanns, Marco Oldiges, Georg Schaumann, Meike Baumgart, Melanie Brocker, Lothar Eggeling, Roland Freudl, Julia Frunzke, Jan Marienhagen, Volker F. Wendisch, Michael Bott
Publikováno v:
Scientific Data, Vol 9, Iss 1, Pp 1-10 (2022)
Abstract Corynebacterium glutamicum is the major host for the industrial production of amino acids and has become one of the best studied model organisms in microbial biotechnology. Rational strain construction has led to an improvement of producer s
Externí odkaz:
https://doaj.org/article/40c95f8ff8694597bb7bae3c633c682c
Publikováno v:
Journal of Biotechnology. 192:96-101
Corynebacterium glutamicum, like Mycobacterium tuberculosis, is a member of the Corynebacteriales, which have linear fatty acids and as branched fatty acids the mycolic acids. We identified accD1 and fasA as key genes of fatty acid synthesis, encodin
Autor:
Michael Vogt, Won-Gi Bang, Karin Krumbach, Michael Bott, Lothar Eggeling, Bianca Klein, Stephan Noack, Jan van Ooyen
Publikováno v:
Applied Microbiology and Biotechnology. 99:791-800
L-Isoleucine is an essential amino acid, which is required as a pharma product and feed additive. Its synthesis shares initial steps with that of L-lysine and L-threonine, and four enzymes of L-isoleucine synthesis have an enlarged substrate specific
Publikováno v:
Engineering in Life Sciences. 13:393-398
The wild type of Corynebacterium glutamicum does not excrete l-lysine, but mutants are developed to use C. glutamicum for the large-scale production of this amino acid. l-lysine is derived from oxaloacetate and pyruvate. A reduced entry of these prec
Publikováno v:
Metabolic engineering. 38
The pentanol isomers 2-methyl-1-butanol and 3-methyl-1-butanol represent commercially interesting alcohols due to their potential application as biofuels. For a sustainable microbial production of these compounds, Corynebacterium glutamicum was engin
Publikováno v:
Biotechnology and Bioengineering. 109:2070-2081
We here developed a series of Corynebacterium glutamicum strains with gradual decreased specific citrate synthase (CS) activity and quantified in a multifaceted approach the consequences of residual activity on the transcriptome, metabolome, and flux
Autor:
Lothar Eggeling, Jan van Ooyen, Michael Bussmann, Bernhard J. Eikmanns, Denise Emer, Michael Bott
Publikováno v:
Journal of Biotechnology. 154:140-148
Citrate synthase (CS) is located at a major branch point in the metabolism and is required for both tricarboxylic acid and glyoxylic acid cycle activity. Here we show that the CS gene gltA of Corynebacterium glutamicum is monocistronic, but that two
Autor:
Jörg Soppa, Jan van Ooyen
Publikováno v:
Microbiology. 153:3303-3313
Two unrelated protein families catalyse the oxidative decarboxylation of 2-oxoacids, i.e. the 2-oxoacid dehydrogenase complexes (OADHCs) and the 2-oxoacid ferredoxin oxidoreductases (OAFORs). In halophilic archaea, OAFORs were found to be responsible
Publikováno v:
Applied and environmental microbiology. 81(22)
Peptidyl-prolyl cis / trans isomerases (PPIases) catalyze the rate-limiting protein folding step at peptidyl bonds preceding proline residues and were found to be involved in several biological processes, including gene expression, signal transductio
Autor:
Michael Vogt, Jan van Ooyen, Sabine Haas, Michael Bott, Simon Klaffl, Tino Polen, Lothar Eggeling
Publikováno v:
Metabolic engineering. 22
Using metabolic engineering, an efficient L-leucine production strain of Corynebacterium glutamicum was developed. In the wild type of C. glutamicum, the leuA-encoded 2-isopropylmalate synthase (IPMS) is inhibited by low L-leucine concentrations with