Výsledky vyhledávání - "Jan den Hartigh"

Eradication of meticillin-resistant Staphylococcus aureus from human skin by the novel LL-37-derived peptide P10 in four pharmaceutical ointments

Autor: Marion Rietveld, Jan W. Drijfhout, Alwin E. Adriaans, Peter H. Nibbering, Kirsten J. M. Schimmel, Robert A. Cordfunke, Suzan Commandeur, Sarah Zwart, Abdoelwaheb El Ghalbzouri, Elisabeth M. Haisma, Anikó Göblyös, Bep Ravensbergen, Jan den Hartigh, Remko van Leeuwen

Publikováno v: International Journal of Antimicrobial Agents, 54(5), 610-618. ELSEVIER

Skin bacterial colonization/infection is a frequent cause of morbidity in patients with chronic wounds and allergic/inflammatory skin diseases. This study aimed to develop a novel approach to eradicate meticillin-resistant Staphylococcus aureus (MRSA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d1d989a7219782a5a850e344b063d61
http://hdl.handle.net/1887/122411

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Development of a Pharmacokinetic Model of Mitotane

Autor: Hester Ettaieb, Henk-Jan Guchelaar, Hans Gelderblom, T M A Kerkhofs, Kees Neef, Luc J J Derijks, Harm R. Haak, Jan den Hartigh

Publikováno v: Therapeutic Drug Monitoring, 37(1), 58-65
Therapeutic Drug Monitoring, 37(1), 58-65. LIPPINCOTT WILLIAMS & WILKINS

Background: Mitotane is the drug of choice in medical treatment of adrenocortical carcinoma. The antineoplastic effect seems to be correlated with a minimum plasma level of 14 mg/L, but plasma concentration build-up is in general slow due to the long

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d7814e9bee6243e56395fb48b75767
https://doi.org/10.1097/ftd.0000000000000102

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Individualized dosing of tyrosine kinase inhibitors: are we there yet?

Autor: Henk-Jan Guchelaar, Hans Gelderblom, Nielka P. van Erp, Djoeke de Wit, Jan den Hartigh

Publikováno v: Drug Discovery Today, 20, 18-36
Drug Discovery Today, 20(1), 18-36
Drug Discovery Today, 20, 1, pp. 18-36

Item does not contain fulltext Tyrosine kinase inhibitors (TKIs) are registered at a fixed oral dose, despite their large variability in pharmacokinetics (PK). Given that the evidence for a relation between drug exposure and treatment outcome is grow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eacc2b2d8b1e792b2e46a7737a2679c
https://hdl.handle.net/2066/153157

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Pharmacodynamics of Cefepime Combined with Tazobactam against Clinically Relevant Enterobacteriaceae in a Neutropenic Mouse Thigh Model

Autor: Maria J. Melchers, Anita C. van Mil, Jan den Hartigh, Claudia M. Lagarde, Johan W. Mouton

Publikováno v: Antimicrobial Agents and Chemotherapy, 61, e00267-17-e00267-17
Antimicrobial Agents and Chemotherapy, 61, 9, pp. e00267-17-e00267-17
Antimicrobial Agents and Chemotherapy, 61(9)
Antimicrobial Agents & Chemotherapy, 61(9):e00267-17. American Society for Microbiology

The lack of new antibiotics has prompted investigation of the combination of two existing agents—cefepime, a broad-spectrum cephalosporin, and tazobactam—to broaden their efficacy against extended-spectrum beta-lactamase (ESBL)-producing Enteroba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::771e13a23e3e38ef0663ca00fbaaa3c1
https://doi.org/10.1128/AAC.00267-17

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Limited Sampling Model for Advanced Mycophenolic Acid Therapeutic Drug Monitoring After Liver Transplantation

Autor: Rogier R. Press, Serge Cremers, Andrzej Baranski, P. Langers, Jan den Hartigh, Bart van Hoek, Akin Inderson

Publikováno v: Therapeutic Drug Monitoring, 36(2), 141-147

The immunosuppressive drug mycophenolate mofetil (MMF), with mycophenolic acid (MPA) as active metabolite, is a nonnephrotoxic alternative to calcineurin inhibitors. Therapeutic drug monitoring (TDM) of MPA may improve clinical benefit from MMF thera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b1958ad212acd7ef1f2cc6e02a39d01
https://doi.org/10.1097/ftd.0b013e3182a37a1e

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A validated assay for the simultaneous quantification of six tyrosine kinase inhibitors and two active metabolites in human serum using liquid chromatography coupled with tandem mass spectrometry

Autor: Trees J. Hessing, Djoeke de Wit, Nielka P. van Erp, Hans Gelderblom, Henk-Jan Guchelaar, Jan den Hartigh

Publikováno v: Journal of Chromatography. B, 937, pp. 33-43
Journal of Chromatography. B, 937, 33-43
Journal of Chromatography B, 937, 33-43

Item does not contain fulltext A sensitive, sophisticated and practical bioanalytical assay for the simultaneous determination of six tyrosine kinase inhibitors (imatinib, sunitinib, nilotinib, dasatinib, pazopanib, regorafenib) and two active metabo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0adf9969d989217bfe900cc7ef0cc8a8
https://doi.org/10.1016/j.jchromb.2013.08.013

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Development of a Nose Cream Containing the Synthetic Antimicrobial Peptide P60.4Ac for Eradication of Methicillin-Resistant Staphylococcus aureus Carriage

Autor: Jan den Hartigh, Anikó Göblyös, Pieter S. Hiemstra, Kirsten J. M. Schimmel, Robert A. Cordfunke, A. Rob P. M. Valentijn, Jaap Oostendorp, Hee Lam Chan, Lorainne M. Fathers, Jan W. Drijfhout, Peter H. Nibbering

Publikováno v: Journal of Pharmaceutical Sciences, 102(10), 3539-3544

Methicillin-resistant Staphylococcus aureus (MRSA) infections are an increasing problem, and current treatment options are suboptimal. Nasal carriage of MRSA is a major risk factor for infection, but nasal eradication strategies are increasingly cons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bb730e05cdcebcc542dea6b5acbdcc2
https://doi.org/10.1002/jps.23695

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Antimicrobial Peptide P60.4Ac-Containing Creams and Gel for Eradication of Methicillin-Resistant Staphylococcus aureus from Cultured Skin and Airway Epithelial Surfaces

Autor: Jan den Hartigh, Jan W. Drijfhout, Anikó Göblyös, Elisabeth M. Haisma, Ronald W. A. L. Limpens, Peter H. Nibbering, Abdoelwaheb El Ghalbzouri, Jasmijn A. Schrumpf, Robert A. Cordfunke, Kirsten J. M. Schimmel, Bep Ravensbergen, Pieter S. Hiemstra, Alwin E Adriaans

Publikováno v: Antimicrobial Agents and Chemotherapy, 60(7), 4063-4072. AMER SOC MICROBIOLOGY
Antimicrobial Agents and Chemotherapy, 60(7), 4063-4072

We previously found the LL-37-derived peptide P60.4Ac to be effective against methicillin-resistant Staphylococcus aureus (MRSA) on human epidermal models (EMs). The goal of this study was to identify the preferred carrier for this peptide for topica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44cbca0d2fc41c35d076f2de67559b8f
https://hdl.handle.net/1887/99322

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Food intervention to make therapy with pazopanib more patient-friendly and affordable

Autor: Angela Colbers, Floor J E Lubberman, Hans Gelderblom, Winette T. A. van der Graaf, Peter F.A. Mulders, David M. Burger, Nielka P. van Erp, Saskia A C Luelmo, Jan den Hartigh, Carla M.L. van Herpen, Frank G A Jansman

Publikováno v: Journal of Clinical Oncology, 34(15). AMER SOC CLINICAL ONCOLOGY

11040Background: Pazopanib has been registered for advanced soft tissue sarcoma (STS) and metastatic renal cell carcinoma (mRCC) and is used at a fixed oral dose of 800 mg taken fasted. However, ingesting pazopanib with food is a more patient friendl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1295388efbd4ed5bd79c2893189efb4
https://research.rug.nl/en/publications/b713ef5d-68f4-45e6-946a-01e314b1d275

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Morphine Induces Hyperalgesia without Involvement of µ-Opioid Receptor or Morphine-3-glucuronide

Autor: Maarten Swartjes, Koen van de Wetering, Jos H Beijnen, Albert Dahan, Amanda R. Waxman, Jan den Hartigh, Caroline A. Arout, Benjamin Kest, René Mooren

Publikováno v: Molecular Medicine. 18:1320-1326

Opioid-induced hyperalgesia (OIH) is a paradoxical increase in pain perception that may manifest during opioid treatment. For morphine, the metabolite morphine-3-glucuronide (M3G) is commonly believed to underlie this phenomenon. Here, in three separ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f6634b010023d9235067cd1382df3fc
https://doi.org/10.2119/molmed.2012.00244

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