Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Jan Zrimec"'
Autor:
Maja Zagorščak, Jan Zrimec, Carissa Bleker, Nadja Nolte, Mojca Juteršek, Živa Ramšak, Kristina Gruden, Marko Petek
Publikováno v:
Frontiers in Plant Science, Vol 15 (2024)
Potato (Solanum tuberosum) is the most popular tuber crop and a model organism. A variety of gene models for potato exist, and despite frequent updates, they are not unified. This hinders the comparison of gene models across versions, limits the abil
Externí odkaz:
https://doaj.org/article/0eac53a5e10a42a2a555498799319e9d
Autor:
Jan Zrimec, Xiaozhi Fu, Azam Sheikh Muhammad, Christos Skrekas, Vykintas Jauniskis, Nora K. Speicher, Christoph S. Börlin, Vilhelm Verendel, Morteza Haghir Chehreghani, Devdatt Dubhashi, Verena Siewers, Florian David, Jens Nielsen, Aleksej Zelezniak
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Design of de novo synthetic regulatory DNA is a promising avenue to control gene expression in biotechnology and medicine. Here the authors present EspressionGAN, a generative adversarial network that uses genomic and transcriptomic data to generate
Externí odkaz:
https://doaj.org/article/bb9aa1851b914f7090a2adb235e06f6d
Autor:
Rasool Saghaleyni, Magdalena Malm, Noah Moruzzi, Jan Zrimec, Ronia Razavi, Num Wistbacka, Hannes Thorell, Anton Pintar, Andreas Hober, Fredrik Edfors, Veronique Chotteau, Per-Olof Berggren, Luigi Grassi, Aleksej Zelezniak, Thomas Svensson, Diane Hatton, Jens Nielsen, Jonathan L. Robinson, Johan Rockberg
Publikováno v:
Cell Reports, Vol 39, Iss 11, Pp 110936- (2022)
Summary: Recombinant protein production can cause severe stress on cellular metabolism, resulting in limited titer and product quality. To investigate cellular and metabolic characteristics associated with these limitations, we compare HEK293 clones
Externí odkaz:
https://doaj.org/article/039c0d28027d41c49243a52c9ff39b2d
Autor:
Gang Li, Yating Hu, Jan Zrimec, Hao Luo, Hao Wang, Aleksej Zelezniak, Boyang Ji, Jens Nielsen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
While temperature impacts the function of all cellular components, it’s hard to rule out how the temperature dependence of cell phenotypes emerged from the dependence of individual components. Here, the authors develop a Bayesian genome scale model
Externí odkaz:
https://doaj.org/article/c4d8dc17c5b3409e95dfdd6fb1d4c551
Autor:
Jan Zrimec, Christoph S. Börlin, Filip Buric, Azam Sheikh Muhammad, Rhongzen Chen, Verena Siewers, Vilhelm Verendel, Jens Nielsen, Mats Töpel, Aleksej Zelezniak
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Regulatory and coding regions of genes are shaped by evolution to control expression levels. Here, the authors use deep learning to identify rules controlling gene expression levels and suggest that all parts of the gene regulatory structure interact
Externí odkaz:
https://doaj.org/article/a9186003c7214e17a2d079a1c50e08ae
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
Utilization of synthetic biology approaches to enhance current plastic degradation processes is of crucial importance, as natural plastic degradation processes are very slow. For instance, the predicted lifetime of a polyethylene terephthalate (PET)
Externí odkaz:
https://doaj.org/article/27ef2d0ac47448b1bfc8c181373dfafd
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Data-driven machine learning is the method of choice for predicting molecular phenotypes from nucleotide sequence, modeling gene expression events including protein-DNA binding, chromatin states as well as mRNA and protein levels. Deep neural network
Externí odkaz:
https://doaj.org/article/c0e2ccb1487a456a858ac610a874838c
Autor:
Gang Li, Jan Zrimec, Boyang Ji, Jun Geng, Johan Larsbrink, Aleksej Zelezniak, Jens Nielsen, Martin KM Engqvist
Publikováno v:
Bioinformatics and Biology Insights, Vol 15 (2021)
Background: A challenge in developing machine learning regression models is that it is difficult to know whether maximal performance has been reached on the test dataset, or whether further model improvement is possible. In biology, this problem is p
Externí odkaz:
https://doaj.org/article/f91f2f6d1f3a43099d369ea653679a51
Autor:
Jan Zrimec, Aleš Lapanje
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract Horizontal gene transfer via plasmid conjugation enables antimicrobial resistance (AMR) to spread among bacteria and is a major health concern. The range of potential transfer hosts of a particular conjugative plasmid is characterised by its
Externí odkaz:
https://doaj.org/article/3526ac343ab744d1b4bfc3bc143535c1
Publikováno v:
Advanced Science, Vol 6, Iss 22, Pp n/a-n/a (2019)
Abstract Biofouling proceeds in successive steps where the primary colonizers affect the phylogenetic and functional structure of a future microbial consortium. Using microbiologically influenced corrosion (MIC) as a study case, a novel approach for
Externí odkaz:
https://doaj.org/article/65097aa951ef44f4ac31be072e8236ed