Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Jan Zitko"'
Autor:
Martin Juhás, Andrea Bachtíková, Daria Elżbieta Nawrot, Paulína Hatoková, Vinod Sukanth Kumar Pallabothula, Adéla Diepoltová, Ondřej Janďourek, Pavel Bárta, Klára Konečná, Pavla Paterová, Vít Šesták, Jan Zitko
Publikováno v:
Pharmaceuticals, Vol 16, Iss 3, p 384 (2023)
In the original publication [...]
Externí odkaz:
https://doaj.org/article/aa4e4ec8b1be476ba24f0f7a8a0e83ab
Autor:
Vinod Sukanth Kumar Pallabothula, Marek Kerda, Martin Juhás, Ondřej Janďourek, Klára Konečná, Pavel Bárta, Pavla Paterová, Jan Zitko
Publikováno v:
Biomolecules, Vol 12, Iss 11, p 1561 (2022)
Multidrug-resistant tuberculosis (MDR-TB) poses a significant threat to mankind and as such earned its place on the WHO list of priority pathogens. New antimycobacterials with a mechanism of action different to currently used agents are highly requir
Externí odkaz:
https://doaj.org/article/8407d76be4d84611821259c8a5fa6dd2
Autor:
Martin Juhás, Andrea Bachtíková, Daria Elżbieta Nawrot, Paulína Hatoková, Vinod Sukanth Kumar Pallabothula, Adéla Diepoltová, Ondřej Janďourek, Pavel Bárta, Klára Konečná, Pavla Paterová, Vít Šesták, Jan Zitko
Publikováno v:
Pharmaceuticals, Vol 15, Iss 5, p 580 (2022)
Antimicrobial drug resistance is currently one of the most critical health issues. Pathogens resistant to last-resort antibiotics are increasing, and very few effective antibacterial agents have been introduced in recent years. The promising drug can
Externí odkaz:
https://doaj.org/article/272fa446ccac49b29f63ff1088d904e1
Synthesis, Biological Evaluation, and In Silico Modeling of N-Substituted Quinoxaline-2-Carboxamides
Autor:
Ghada Bouz, Sarah Bouz, Ondřej Janďourek, Klára Konečná, Pavel Bárta, Jarmila Vinšová, Martin Doležal, Jan Zitko
Publikováno v:
Pharmaceuticals, Vol 14, Iss 8, p 768 (2021)
Despite the established treatment regimens, tuberculosis remains an alarming threat to public health according to WHO. Novel agents are needed to overcome the increasing rate of resistance and perhaps achieve eradication. As part of our long-term res
Externí odkaz:
https://doaj.org/article/9837cdb516af40088446b84f4bb1efd2
Autor:
Luping Pang, Stephen D. Weeks, Martin Juhás, Sergei V. Strelkov, Jan Zitko, Arthur Van Aerschot
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 7793 (2021)
Human cytosolic prolyl-tRNA synthetase (HcProRS) catalyses the formation of the prolyl-tRNAPro, playing an important role in protein synthesis. Inhibition of HcProRS activity has been shown to have potential benefits in the treatment of fibrosis, aut
Externí odkaz:
https://doaj.org/article/dfaabee4a65b4218937b61f6a288934d
Autor:
Weronika Ambrożkiewicz, Marta Kučerová-Chlupáčová, Ondřej Janďourek, Klára Konečná, Pavla Paterová, Pavel Bárta, Jarmila Vinšová, Martin Doležal, Jan Zitko
Publikováno v:
Molecules, Vol 25, Iss 7, p 1561 (2020)
According to the World Health Organization, tuberculosis is still in the top ten causes of death from a single infectious agent, killing more than 1.7 million people worldwide each year. The rising resistance developed by Mycobacterium tuberculosis a
Externí odkaz:
https://doaj.org/article/cbb2f0eea373485fbfbe31ebb479da48
Autor:
Martin Juhás, Lucie Kučerová, Ondřej Horáček, Ondřej Janďourek, Vladimír Kubíček, Klára Konečná, Radim Kučera, Pavel Bárta, Jiří Janoušek, Pavla Paterová, Jiří Kuneš, Martin Doležal, Jan Zitko
Publikováno v:
Molecules, Vol 25, Iss 7, p 1518 (2020)
Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis (Mtb), each year causing millions of deaths. In this article, we present the synthesis and biological evaluations of new potential antimycobacterial compounds containing a fra
Externí odkaz:
https://doaj.org/article/3ebe505765e4433694cb85089c82811a
Autor:
Ghada Bouz, Martin Juhás, Lluis Pausas Otero, Cristina Paredes de la Red, Ondřej Janďourek, Klára Konečná, Pavla Paterová, Vladimír Kubíček, Jiří Janoušek, Martin Doležal, Jan Zitko
Publikováno v:
Molecules, Vol 25, Iss 1, p 138 (2019)
We prepared a series of substituted N-(pyrazin-2-yl)benzenesulfonamides as an attempt to investigate the effect of different linkers connecting pyrazine to benzene cores on antimicrobial activity when compared to our previous compounds of amide or re
Externí odkaz:
https://doaj.org/article/4cd83c171006456d912e56b43889f76b
Autor:
Lucia Semelkova, Klara Konecna, Pavla Paterova, Vladimir Kubicek, Jiri Kunes, Lucie Novakova, Jan Marek, Lieve Naesens, Matus Pesko, Katarina Kralova, Martin Dolezal, Jan Zitko
Publikováno v:
Molecules, Vol 20, Iss 5, Pp 8687-8711 (2015)
A series of N-alkyl-3-(alkylamino)pyrazine-2-carboxamides and their N-alkyl-3-chloropyrazine-2-carboxamide precursors were prepared. All compounds were characterized by analytical methods and tested for antimicrobial and antiviral activity. The antim
Externí odkaz:
https://doaj.org/article/3653008a8d034514ae0939014f3aae09
Autor:
Ondrej Jandourek, Martin Dolezal, Jiri Kunes, Vladimir Kubicek, Pavla Paterova, Matus Pesko, Vladimir Buchta, Katarina Kralova, Jan Zitko
Publikováno v:
Molecules, Vol 19, Iss 7, Pp 9318-9338 (2014)
A series of 18 N-alkyl substituted 3-aminopyrazine-2-carboxamides was prepared in this work according to previously experimentally set and proven conditions using microwave assisted synthesis methodology. This approach for the aminodehalogenation rea
Externí odkaz:
https://doaj.org/article/e67a8d04c70a4355bea366772026d6dc