Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Jan Wouter Drijfhout"'
Autor:
Nesrine Bouhrour, Tanny J. K. van der Reijden, Michella M. Voet, Bep Schonkeren-Ravensbergen, Robert A. Cordfunke, Jan Wouter Drijfhout, Farida Bendali, Peter H. Nibbering
Publikováno v:
Antibiotics, Vol 12, Iss 12, p 1743 (2023)
The antibiotic management of catheter-related infections (CRIs) often fails owing to the emergence of antimicrobial-resistant strains and/or biofilm/persister apparitions. Thus, we investigated the efficacy of two novel antimicrobial agents, i.e., th
Externí odkaz:
https://doaj.org/article/af0519dbe2154ec59334aa1c7d95c655
Autor:
Iris N. Pardieck, Tetje C. van der Sluis, Esmé T. I. van der Gracht, Dominique M. B. Veerkamp, Felix M. Behr, Suzanne van Duikeren, Guillaume Beyrend, Jasper Rip, Reza Nadafi, Elham Beyranvand Nejad, Nils Mülling, Dena J. Brasem, Marcel G. M. Camps, Sebenzile K. Myeni, Peter J. Bredenbeek, Marjolein Kikkert, Yeonsu Kim, Luka Cicin-Sain, Tamim Abdelaal, Klaas P. J. M. van Gisbergen, Kees L. M. C. Franken, Jan Wouter Drijfhout, Cornelis J. M. Melief, Gerben C. M. Zondag, Ferry Ossendorp, Ramon Arens
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Vaccination regimens and the number of doses required for optimal immunity and protection are critical factors in the translation of vaccines. Here the authors show administration of a three dose protocol of a single T cell epitope to the SARS-CoV-2
Externí odkaz:
https://doaj.org/article/cd51eadba8a3427fbfa02b68f915520a
Autor:
Willemijn van der Wulp, Anna M. Gram, Boris Bleijlevens, Renate S. Hagedoorn, Can Araman, Robbert Q. Kim, Jan Wouter Drijfhout, Paul W. H. I. Parren, Richard G. Hibbert, Rob C. Hoeben, Sander I. van Kasteren, Janine Schuurman, Maaike E. Ressing, Mirjam H. M. Heemskerk
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Therapeutic antibody-epitope conjugates (AECs) are promising new modalities to deliver immunogenic epitopes and redirect virus-specific T-cell activity to cancer cells. Nevertheless, many aspects of these antibody conjugates require optimization to i
Externí odkaz:
https://doaj.org/article/458e15a064ab40b08049bc6f97a6578d
Autor:
Miriam E. van Gent, Bep Schonkeren-Ravensbergen, Asma Achkif, Daan Beentjes, Natasja Dolezal, Krista E. van Meijgaarden, Jan Wouter Drijfhout, Peter H. Nibbering
Publikováno v:
Journal of Innate Immunity, Pp 1-1 (2023)
Synthetic antibacterial and anti-biofilm peptide (SAAP)-148 was developed to combat bacterial infections not effectively treatable with current antibiotics. SAAP-148 is highly effective against antimicrobial-resistant bacteria without inducing resist
Externí odkaz:
https://doaj.org/article/76b66b7d2eca43a99e7ec8371c01fedc
Autor:
Ayse Ön, Djenana Vejzovic, James Jennings, Lena Parigger, Robert A. Cordfunke, Jan Wouter Drijfhout, Karl Lohner, Nermina Malanovic
Publikováno v:
Antibiotics, Vol 12, Iss 7, p 1163 (2023)
OP-145 and SAAP-148, two 24-mer antimicrobial peptides derived from human cathelicidin LL-37, exhibit killing efficacy against both Gram-positive and Gram-negative bacteria at comparable peptide concentrations. However, when it comes to the killing a
Externí odkaz:
https://doaj.org/article/6b4dd8f2c7874557aee2f6e8f7a1acba
Autor:
Colin Bournez, Martijn Riool, Leonie de Boer, Robert A. Cordfunke, Leonie de Best, Remko van Leeuwen, Jan Wouter Drijfhout, Sebastian A. J. Zaat, Gerard J. P. van Westen
Publikováno v:
Antibiotics, Vol 12, Iss 4, p 725 (2023)
To combat infection by microorganisms host organisms possess a primary arsenal via the innate immune system. Among them are defense peptides with the ability to target a wide range of pathogenic organisms, including bacteria, viruses, parasites, and
Externí odkaz:
https://doaj.org/article/bba35ed07cc441348c3987da0c9147cf
Autor:
Miriam E. van Gent, Tom van Baaren, Sylvia N. Kłodzińska, Muhanad Ali, Natasja Dolezal, Bjorn R. van Doodewaerd, Erik Bos, Amy M. de Waal, Roman I. Koning, Jan Wouter Drijfhout, Hanne Mørck Nielsen, Peter H. Nibbering
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 429 (2023)
Chronic wound infections colonized by bacteria are becoming more difficult to treat with current antibiotics due to the development of antimicrobial resistance (AMR) as well as biofilm and persister cell formation. Synthetic antibacterial and antibio
Externí odkaz:
https://doaj.org/article/b518551780ec46efb7e3e99e2e77ddab
Autor:
Miriam E. van Gent, Tanny J. K. van der Reijden, Patrick R. Lennard, Adriëtte W. de Visser, Bep Schonkeren-Ravensbergen, Natasja Dolezal, Robert A. Cordfunke, Jan Wouter Drijfhout, Peter H. Nibbering
Publikováno v:
Antibiotics, Vol 11, Iss 5, p 673 (2022)
Recently, using a deep learning approach, the novel antibiotic halicin was discovered. We compared the antibacterial activities of two novel bactericidal antimicrobial agents, i.e., the synthetic antibacterial and antibiofilm peptide (SAAP)-148 with
Externí odkaz:
https://doaj.org/article/14e56718b98c40b79d1011d2b3794d33
Autor:
Paulina Piller, Heimo Wolinski, Robert A. Cordfunke, Jan Wouter Drijfhout, Sandro Keller, Karl Lohner, Nermina Malanovic
Publikováno v:
Biomolecules, Vol 12, Iss 4, p 523 (2022)
The development of antimicrobial agents against multidrug-resistant bacteria is an important medical challenge. Antimicrobial peptides (AMPs), human cathelicidin LL-37 and its derivative OP-145, possess a potent antimicrobial activity and were under
Externí odkaz:
https://doaj.org/article/46e80550e57d4f48b239ea04b59ff369
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
The mode of action of four cationic amphipathic antimicrobial peptides (AMPs) was evaluated against the non-pathogenic, Gram-positive, spore-forming bacterium, Bacillus subtilis. The AMPs were TC19, TC84, BP2, and the lantibiotic Nisin A. TC19 and TC
Externí odkaz:
https://doaj.org/article/b12ae0f97e3648898b68f4ab138db448