Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Jan Wim Vrijbloed"'
Autor:
Jan Wim Vrijbloed, Olena Butenko, Ruggero Fariello, Consuelo Filippo, Marina Boido, Alessandro Vercelli, Roberta Schellino
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 3, p e0228653 (2020)
PLoS ONE, Vol 15, Iss 3, p e0228653 (2020)
Current efforts to improve muscle performance are focused on muscle trophism via inhibition of the myostatin pathway: however they have been unsuccessful in the clinic to date. In this study, a novel protein has been created by combining the soluble
Autor:
Steven J. Demarco, Kerstin Moehle, Christian Ludin, Thomas Klimkait, François Hamy, Federico Brianza, Vincent Brondani, Sergio Lociuro, Alexander Lederer, Frank Gombert, John A. Robinson, Jürg Zumbrunn, Reshmi Mukherjee, Heiko Henze, Jean-Pierre Obrecht, Daniel Obrecht, Barbara Romagnoli, Jan Wim Vrijbloed
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:8396-8404
Novel highly potent CXCR4 inhibitors with good pharmacokinetic properties were designed and optimized starting from the naturally occurring beta-hairpin peptide polyphemusin II. The design involved incorporating important residues from polyphemusin I
Autor:
Kerstin Moehle, Oliver Zerbe, Jan Wim Vrijbloed, Ricardo Augusto Dias, John A. Robinson, Daniel Obrecht, Rudi Fasan
Publikováno v:
Angewandte Chemie. 116:2161-2164
The design of novel protein ligands and inhibitors of protein– protein interactions is an important goal in post-genomic proteome analyses and in drug and vaccine discovery. Unfortunately, the design of synthetic molecules that target surface-expos
Publikováno v:
The Journal of Biological Chemistry, 277(38), 34785-34792. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
The cytoplasmic coenzyme NAD(+)-dependent alcohol (methanol) dehydrogenase (MDH) employed by Bacillus methanolicus during growth on C(1)-C(4) primary alcohols is a decameric protein with 1 Zn(2+)-ion and 1-2 Mg(2+)-ions plus a tightly bound NAD(H) co
Autor:
Shuo Lin, Monika Haubitz, Filippo Oliveri, Jan Wim Vrijbloed, Markus A. Rüegg, Stefan Kucsera, Stefan Hettwer, Ruggero Fariello
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 2, p e88739 (2014)
PLoS ONE, Vol 9, Iss 2, p e88739 (2014)
Treatment of neuromuscular diseases is still an unsolved problem. Evidence over the last years strongly indicates the involvement of malformation and dysfunction of neuromuscular junctions in the development of such medical conditions. Stabilization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::068ad78c8590a3336a7135ae7551d01f
https://edoc.unibas.ch/34842/
https://edoc.unibas.ch/34842/
Autor:
Pius Dahinden, Guido M. Schuster, Michael Drey, Christoph Beeler, Jürgen M. Bauer, Armin Mäder, Benjamin Krieger, Thomas Bertsch, Thomas Unterer, Jan Wim Vrijbloed, Stefan Zollinger, Cornel C. Sieber, Stefan Hettwer
Publikováno v:
Journal of the American Medical Directors Association. 15(6)
Sarcopenia, age-related muscle wasting, is associated with increased morbidity and mortality in the affected individuals. The pathogenesis of sarcopenia is not yet fully understood. A multifactorial concept is currently favored. The reduced number of
Autor:
Katja Zerbe-Burkhardt, John A. Robinson, Andreas Grubelnik-Leiser, Jan Wim Vrijbloed, Ananda Ratnatilleke
Publikováno v:
Journal of Bacteriology. 181:5600-5605
The coenzyme B 12 -dependent isobutyryl coenzyme A (CoA) mutase (ICM) and methylmalonyl-CoA mutase (MCM) catalyze the isomerization of n -butyryl-CoA to isobutyryl-CoA and of methylmalonyl-CoA to succinyl-CoA, respectively. The influence that both mu
Publikováno v:
Journal of Molecular Biology. 285:805-815
A complex formed between the extracellular human interferon gamma receptor alpha-chain (hIFNgammaR) and the Fab fragment of the neutralizing antibody A6 has been studied by site-directed mutagenesis. Five complementarity determining regions of the A6
Autor:
Nathalie Philippon, John A. Robinson, Daniel Hess, Peter Hunziker, Katja Zerbe-Burkhardt, Jan Wim Vrijbloed, Ananda Ratnatilleke, Ashley Birch, Andreas Leiser
Publikováno v:
Journal of Biological Chemistry. 273:6508-6517
Purification of the coenzyme B12-dependent isobutyryl-CoA mutase (ICM) from Streptomyces cinnamonensis gave a protein of approximately 65 kDa by SDS-polyacrylamide gel electrophoresis, whose gene icmA was cloned using sequences derived from tryptic p
Publikováno v:
FEMS Microbiology Letters, 136(3), 275-281. Oxford University Press
Mutants of the actinomycete Amycolatopsis methanolica blocked in aromatic amino acid biosynthesis were isolated using brief ultrasonic treatments to obtain single cells. After UV irradiation, auxotrophic mutants were selected as pinpoint colonies on