Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Jan Willem Van der Laan"'
Autor:
Todd Bourcier, Timothy McGovern, Tania Cavaliero, Geoffrey Ebere, Akiyoshi Nishikawa, Jihei Nishimura, Kumiko Ogawa, Markku Pasanen, Alisa Vespa, Jan Willem Van der Laan
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
Introduction: The International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) initiated a process in 2012 to revise the S1B Guideline “Testing for Carcinogenicity of Pharmaceuticals”. Previous retrosp
Externí odkaz:
https://doaj.org/article/33fbb9510add4dbf852e75ae21296a20
Autor:
Jan Willem Van Der Laan
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
Externí odkaz:
https://doaj.org/article/e9101fb0412f401ebcf10bfe54d955e0
Autor:
Jan Willem Van Der Laan, Wenny Buitenhuis, Laura Wagenaar, Ans Soffers, Eugene van Someren, Cyrille Krul, Ruud Woutersen
Publikováno v:
Frontiers in Medicine, Vol 3 (2016)
In an exercise designed to reduce animal use, we analysed the results of rat sub-chronic toxicity studies from 289 pharmaceutical compounds with the aim to predict the tumour outcome of carcinogenicity studies in this species. The results were obtain
Externí odkaz:
https://doaj.org/article/d2a51666cf6d46ac9e73565fb53125b4
Autor:
J Christopher Corton, Constance A Mitchell, Scott Auerbach, Pierre Bushel, Heidrun Ellinger-Ziegelbauer, Patricia A Escobar, Roland Froetschl, Alison H Harrill, Kamin Johnson, James E Klaunig, Arun R Pandiri, Alexei A Podtelezhnikov, Julia E Rager, Keith Q Tanis, Jan Willem van der Laan, Alisa Vespa, Carole L Yauk, Syril D Pettit, Frank D Sistare
Publikováno v:
Toxicological Sciences. 188:4-16
There is growing recognition across broad sectors of the scientific community that use of genomic biomarkers has the potential to reduce the need for conventional rodent carcinogenicity studies of industrial chemicals, agrochemicals, and pharmaceutic
Autor:
Tineke van den Hoorn, Jan Willem van der Laan, Peter Bouwman, Annabel Goudriaan, Sylvia E. Le Dévédec, Wanda van der Stel, Bob van de Water, Britt Duijndam
Publikováno v:
Toxicological Sciences
Toxicological Sciences, 181(2), 187-198. Oxford University Press (OUP)
Toxicological Sciences, 181(2), 187-198. Oxford University Press (OUP)
Estrogen receptor alpha (ERα) belongs to the nuclear hormone receptor family of ligand-inducible transcription factors and regulates gene networks in biological processes such as cell growth and proliferation. Disruption of these networks by chemica
Autor:
Peter van Meer, Jan Willem van der Laan, Carla Herberts, Tineke van den Hoorn, Peter T. Theunissen
Publikováno v:
British Journal of Clinical Pharmacology. 87:2425-2427
Autor:
Ruud A. Woutersen, Frédéric Schorsch, Marco Corvaro, Robin Gommans, Phil Botham, Gerrit Wolterink, Jan Willem van der Laan, Raffaella Corvi, Irene Manou, Federica Madia, Harm J. Heusinkveld, Jyotigna Mehta, Mirjam Luijten, Dick Lewis, Hedwig M. Braakhuis
Chemical substances are subjected to assessment of genotoxic and carcinogenic effects before being marketed to protect man and the environment from health risks. For agrochemicals, the long-term rodent carcinogenicity study is currently required from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b440c09a4b5cd12a6f885f03ceb039c
http://hdl.handle.net/10029/624557
http://hdl.handle.net/10029/624557
Autor:
A. Charlotte M. T. de Wolf, Anna M G Pasmooij, Jan Willem van der Laan, Tahira Nakchedi, Carla Herberts, Tineke van den Hoorn
Publikováno v:
British journal of clinical pharmacologyREFERENCES. 87(6)
Aims The field of cell-based therapies for human diseases is currently evolving from promising treatment options to established therapeutic concepts. The design of the nonclinical development program for cell-based products, intended to provide a rat
Evaluation of Juvenile Animal Studies for Pediatric CNS-Targeted Compounds: A Regulatory Perspective
Autor:
Jan Willem van der Laan, Nico C B de Jager, Cláudio Gouveia Roque, Isabel Vieira, Jacqueline Carleer, Karen van Malderen, Dinah Duarte, Fabien Lavergne, Lutz Wiesner, Gunter F. Egger
Publikováno v:
International Journal of Toxicology. SAGE Publications Inc.
Central nervous system (CNS)-targeted products are an important category of pediatric pharmaceuticals. In view of the significant postnatal maturation of the CNS, juvenile animal studies (JAS) are performed to support pediatric development of these n