Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Jan Willem Van Der Laan"'
Autor:
Todd Bourcier, Timothy McGovern, Tania Cavaliero, Geoffrey Ebere, Akiyoshi Nishikawa, Jihei Nishimura, Kumiko Ogawa, Markku Pasanen, Alisa Vespa, Jan Willem Van der Laan
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
Introduction: The International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) initiated a process in 2012 to revise the S1B Guideline “Testing for Carcinogenicity of Pharmaceuticals”. Previous retrosp
Externí odkaz:
https://doaj.org/article/33fbb9510add4dbf852e75ae21296a20
Autor:
Jan Willem Van Der Laan
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
Externí odkaz:
https://doaj.org/article/e9101fb0412f401ebcf10bfe54d955e0
Autor:
Jan Willem Van Der Laan, Wenny Buitenhuis, Laura Wagenaar, Ans Soffers, Eugene van Someren, Cyrille Krul, Ruud Woutersen
Publikováno v:
Frontiers in Medicine, Vol 3 (2016)
In an exercise designed to reduce animal use, we analysed the results of rat sub-chronic toxicity studies from 289 pharmaceutical compounds with the aim to predict the tumour outcome of carcinogenicity studies in this species. The results were obtain
Externí odkaz:
https://doaj.org/article/d2a51666cf6d46ac9e73565fb53125b4
Autor:
J Christopher Corton, Constance A Mitchell, Scott Auerbach, Pierre Bushel, Heidrun Ellinger-Ziegelbauer, Patricia A Escobar, Roland Froetschl, Alison H Harrill, Kamin Johnson, James E Klaunig, Arun R Pandiri, Alexei A Podtelezhnikov, Julia E Rager, Keith Q Tanis, Jan Willem van der Laan, Alisa Vespa, Carole L Yauk, Syril D Pettit, Frank D Sistare
Publikováno v:
Toxicological Sciences. 188:4-16
There is growing recognition across broad sectors of the scientific community that use of genomic biomarkers has the potential to reduce the need for conventional rodent carcinogenicity studies of industrial chemicals, agrochemicals, and pharmaceutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab1ea167ef959d91cb05ee2aeb0e6fc9
https://doi.org/10.1093/toxsci/kfac041
https://doi.org/10.1093/toxsci/kfac041
Autor:
Tineke van den Hoorn, Jan Willem van der Laan, Peter Bouwman, Annabel Goudriaan, Sylvia E. Le Dévédec, Wanda van der Stel, Bob van de Water, Britt Duijndam
Publikováno v:
Toxicological Sciences
Toxicological Sciences, 181(2), 187-198. Oxford University Press (OUP)
Toxicological Sciences, 181(2), 187-198. Oxford University Press (OUP)
Estrogen receptor alpha (ERα) belongs to the nuclear hormone receptor family of ligand-inducible transcription factors and regulates gene networks in biological processes such as cell growth and proliferation. Disruption of these networks by chemica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc2ab5cb7a285a46135273e8519eebd
https://doi.org/10.1093/toxsci/kfab037
https://doi.org/10.1093/toxsci/kfab037
Autor:
Peter van Meer, Jan Willem van der Laan, Carla Herberts, Tineke van den Hoorn, Peter T. Theunissen
Publikováno v:
British Journal of Clinical Pharmacology. 87:2425-2427
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1efa0ba8ea7c5175ee491a98a5957f9
https://doi.org/10.1111/bcp.14544
https://doi.org/10.1111/bcp.14544
Autor:
Ruud A. Woutersen, Frédéric Schorsch, Marco Corvaro, Robin Gommans, Phil Botham, Gerrit Wolterink, Jan Willem van der Laan, Raffaella Corvi, Irene Manou, Federica Madia, Harm J. Heusinkveld, Jyotigna Mehta, Mirjam Luijten, Dick Lewis, Hedwig M. Braakhuis
Chemical substances are subjected to assessment of genotoxic and carcinogenic effects before being marketed to protect man and the environment from health risks. For agrochemicals, the long-term rodent carcinogenicity study is currently required from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b440c09a4b5cd12a6f885f03ceb039c
http://hdl.handle.net/10029/624557
http://hdl.handle.net/10029/624557
Autor:
A. Charlotte M. T. de Wolf, Anna M G Pasmooij, Jan Willem van der Laan, Tahira Nakchedi, Carla Herberts, Tineke van den Hoorn
Publikováno v:
British journal of clinical pharmacologyREFERENCES. 87(6)
Aims The field of cell-based therapies for human diseases is currently evolving from promising treatment options to established therapeutic concepts. The design of the nonclinical development program for cell-based products, intended to provide a rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3d57ab29450e8257914e1348bf42471
https://pubmed.ncbi.nlm.nih.gov/32790909
https://pubmed.ncbi.nlm.nih.gov/32790909
Autor:
Emiel Rorije, Edwin P. Zwart, Evelyn D. Olthof, Hedwig M. Braakhuis, Wout Slob, Mirjam Luijten, Jan van Benthem, Gerrit Wolterink, Ruud Woutersen, Jan Willem van der Laan, Eric R. Gremmer
Publikováno v:
Critical Reviews in Toxicology. 48:500-511
Non-genotoxic carcinogens (NGTXCs) do not cause direct DNA damage but induce cancer via other mechanisms. In risk assessment of chemicals and pharmaceuticals, carcinogenic risks are determined using carcinogenicity studies in rodents. With the aim to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e37aa5f02448a20eadd96effface8cf6
https://doi.org/10.1080/10408444.2018.1458818
https://doi.org/10.1080/10408444.2018.1458818