Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Jan Willem Thuring"'
Autor:
Min Chul Kwon, Olivier Querolle, Xuedong Dai, Jan Willem Thuring, Tinne Verhulst, Ann Marien, Dries Goffin, Wei Cai, Vikki Keersmaekers, Filmon Eyassu, Karin Verstraeten, Sara El Ashkar, Shanna M Hogeling, Frank Jacob, Petra Vinken, Nicolas Darville, Vineet Pande, Daniel Krosky, Gregor Urbanietz, Bie Verbist, Lucille A. Ferrante, Christina Diane Drenberg, David Wilson, Ricardo M. Attar, Jan Jacob Schuringa, Nikki Daskalakis, Kathryn Packman, Christine Pietsch, Yusri Elsayed, Ulrike Philippar
Publikováno v:
Blood. 140:5928-5929
Autor:
Zeina Neouchy, Jan Hullaert, Jonas Verhoeven, Lieven Meerpoel, Jan-Willem Thuring, Guido Verniest, Johan Winne
The synthesis of cyclopropyl pinacol boronic esters from dibromocyclopropanes via Matteson–Pasto rearrangement is reported. The method is readily scalable and shows limited levels of stereoinduction, with a selectivity that is in part complementary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cdc3adf115e0176c7967ec1d75f8435
https://biblio.vub.ac.be/vubir/synthesis-of-cyclopropyl-pinacol-boronic-esters-from-dibromocyclopropanes(41234753-b831-4e2e-9931-f543901fa654).html
https://biblio.vub.ac.be/vubir/synthesis-of-cyclopropyl-pinacol-boronic-esters-from-dibromocyclopropanes(41234753-b831-4e2e-9931-f543901fa654).html
Autor:
Jan Willem Thuring, Hanchu Kong, Guido Verniest, Wenbin Wang, Kristof Van Hecke, Lieven Meerpoel, Yongbin Zhao, Vineet Pande, Marta Brambilla, Jonas Verhoeven
Publikováno v:
Synlett. 32:892-896
The stereoselective preparation of a novel 4′-spirocyclopropyl nucleoside analogue has been developed by using a semibenzilic Favorskii rearrangement of a 4′-(2-chloro-3-oxocyclobutyl)spirofuranose as a key step. These chiral spirocyclic intermed
Autor:
Lijs Beke, Didier Berthelot, David Brown, Colin Robinson, Lieven Meerpoel, Weimei Sun, Dirk Brehmer, Tongfei Wu, Viellevoye Marcel, Thomas Nys, Cois Sommen, Jordi Corbera, Vineet Pande, Marc Parade, Steve Irving, Jan Willem Thuring
Publikováno v:
ACS Med Chem Lett
[Image: see text] Protein arginine methyltransferase 5 (PRMT5) is an enzyme that can symmetrically dimethylate arginine residues in histones and nonhistone proteins by using S-adenosyl methionine (SAM) as the methyl donating cofactor. We have designe
Autor:
Ann Vos, Freija De Vleeschouwer, Tongfei Wu, Guido Verniest, Jan Willem Thuring, Weimei Sun, Jonas Verhoeven, Hanchu Kong, Vineet Pande, Kristof Van Hecke, Lieven Meerpoel
Publikováno v:
Chemistry – A European Journal. 25:15419-15423
Despite the large variety of modified nucleosides that have been reported, the preparation of constrained 4 '-spirocyclic adenosine analogues has received very little attention. We discovered that the [2+2]-cycloaddition of dichloroketene on readily
Autor:
Zeina, Neouchy, Jonas, Verhoeven, Hanchu, Kong, Yongbin, Zhao, Wenbin, Wang, Marta, Brambilla, Kristof, Van Hecke, Lieven, Meerpoel, Jan Willem, Thuring, Guido, Verniest, Johan, Winne
Publikováno v:
The Journal of organic chemistry. 86(23)
Cyclopropane fusion of the only rotatable carbon-carbon bond in furanosyl nucleosides (i.e., exocyclic 4'-5') is a powerful design strategy to arrive at conformationally constrained analogues. Herein, we report a direct stereodivergent route toward t
Autor:
Guido Verniest, Yongbin Zhao, Lucile Marguerite Jouffroy, Jan Willem Thuring, Hanchu Kong, Jonas Verhoeven, Marta Brambilla, Wenbin Wang, Lieven Meerpoel, Johan M. Winne
Publikováno v:
Organic letters. 23(22)
Novel C-4′,C-5′ cyclobutane-fused spirocyclic ribonucleoside analogues were prepared. Thermal [2 + 2] cycloaddition between dichloroketene and readily derived 4′-exo-methylene furanoses afforded a first entry to the required constrained ribofur
Autor:
Tinne Verhulst, Lieven Meerpoel, Emmanuel Gustin, Weimei Sun, Matthew V. Lorenzi, Junchen Gu, Longen Zhou, Wim Bert Griet Schepens, Hillary Millar, Tongfei Wu, Viellevoye Marcel, Vineet Pande, Petra Vinken, Desiree De Lange, An Boeckx, Christopher Moy, Friederike Pastore, Geert Mannens, Sylvie Laquerre, Ulrike Philippar, Vipul Bhargava, Gaston Stanislas Marcella Diels, Thomas Nys, Kathryn Packman, Jan Willem Thuring, Erika van Heerde, Bie Verbist, Sumit Rai, Lijs Beke, Pegah Safabakhsh, Timothy A. Graubert, Yue Fan, Angelique N Gilbert, Dirk Brehmer, Vikki Keersmaekers, Barbara Morschhäuser, Danilo Fiore, David Walker, Amy J. Johnson
Publikováno v:
Molecular cancer therapeutics. 20(12)
The protein arginine methyltransferase 5 (PRMT5) methylates a variety of proteins involved in splicing, multiple signal transduction pathways, epigenetic control of gene expression, and mechanisms leading to protein expression required for cellular p
Autor:
Weimei Sun, Jan Willem Thuring, Frank De Proft, Xavier Deraet, Mercedes Alonso, Lieven Meerpoel, Guido Verniest, Jonas Verhoeven, Vineet Pande
Publikováno v:
The Journal of organic chemistry. 85(23)
A novel class of substituted spiro[3.4]octanes can be accessed via a [2 + 2]-cycloaddition of dichloroketene on a readily prepared exo-methylene cyclopentane building block. This reaction sequence was found to be robust on a multigram scale and affor
Autor:
Lucile Jouffroy, Jonas Verhoeven, Marta Brambilla, Guido Verniest, Hanchu Kong, Yongbin Zhao, Wenbin Wang, Lieven Meerpoel, Jan Willem Thuring, Johan M. Winne
Publikováno v:
Organic Letters. 24:798-798