Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jan Willem Terpstra"'
Autor:
Nancy Faber-Hilhorst, Adri van den Hoogenband, Jack A. J. den Hartog, Josephus H. M. Lange, Jan Willem Terpstra
Publikováno v:
Tetrahedron Letters. 50:5040-5043
An efficient three-step synthetic route from 2,6-dichloro-4-iodopyridine to 1,3-dichloro-5,8-dihydroisoquinoline is described. A ring-closing-metathesis reaction constitutes the key step in this synthetic sequence. The reactivity of both chloro atoms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96badea33afc905a9618d583657c67e5
https://doi.org/10.1016/j.tetlet.2009.06.101
https://doi.org/10.1016/j.tetlet.2009.06.101
Autor:
Paul C. J. Kamer, Gino P. F. van Strijdonck, Adri van den Hoogenband, Jan Willem Terpstra, Mark Kuil, Piet W. N. M. van Leeuven, Gerben M. Visser, E. Koen Bekedam
Publikováno v:
Tetrahedron Letters, 46(14), 2405-2409
Tetrahedron Letters 46 (2005) 14
Tetrahedron Letters, 46(14), 2405-2409. Elsevier
Tetrahedron Letters 46 (2005) 14
Tetrahedron Letters, 46(14), 2405-2409. Elsevier
A highly efficient copper(I)-catalyzed N -arylation of azaheterocycles with various aryl halides is reported. The N -arylation reaction can be carried out using as low as 0.5 mol % of (Cu(I)OTf) 2 ·PhH and 1.0 mol % of 4,7-dichloro-1,10-phenanthroli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c51179edacccff23c7790ddeaf552e72
https://doi.org/10.1016/j.tetlet.2005.02.074
https://doi.org/10.1016/j.tetlet.2005.02.074
Autor:
Johann T. B. H. Jastrzebski, Melle Koch, Josephus H. M. Lange, Ties J. Korstanje, Jan Willem Terpstra, Adri van den Hoogenband, Visser Gerben M, Martin Visser
Publikováno v:
Tetrahedron Letters 49 (2008) 26
Tetrahedron Letters, 49(26), 4122-4124
Tetrahedron Letters, 49(26), 4122-4124
A Ruphos-mediated Suzuki cross-coupling between (hetero)aryl bromides and secondary alkyltrifluoroborates is described using palladium catalysis. The Ruphos ligand showed superior properties as compared to S-Phos in this type of reaction. This method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbe3b02282305ffbb7cf728863a8d79e
https://doi.org/10.1016/j.tetlet.2008.04.129
https://doi.org/10.1016/j.tetlet.2008.04.129
Publikováno v:
Tetrahedron Letters. 45:8535-8537
A novel efficient synthetic route to the pharmaceutical key intermediate N -(piperidin-4-yl)-1,3-dihydroindol-2-one is described. The key step involves a high-yielding intramolecular palladium-catalyzed amination reaction using Buchwald’s X-Phos li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0b8259a06e1c6fdbdfcdf5e4c8cbe2e
https://doi.org/10.1016/j.tetlet.2004.09.121
https://doi.org/10.1016/j.tetlet.2004.09.121
Publikováno v:
Journal of medicinal chemistry. 51(11)
A novel scoring algorithm based on molecular interaction fingerprints (IFPs) was comparatively evaluated in its scaffold hopping efficiency against four virtual screening standards (GlideXP, Gold, ROCS, and a Bayesian classifier). Decoy databases for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82051a8be3fab806a46cf5b7a8b3701f
https://pubmed.ncbi.nlm.nih.gov/18447336
https://pubmed.ncbi.nlm.nih.gov/18447336
Autor:
Adri van den Hoogenband, Feenstra Roelof W, Wouter I. Iwema-Bakker, Jack A. J. den Hartog, Jan Willem Terpstra, Josephus H. M. Lange, Jord van Schaik
Publikováno v:
ChemInform. 37
An unprecedented synthetic approach to novel 4-aryl-1-methyloxindoles is described. The method involves the intramolecular palladium-catalyzed amidation of N-methyl-2,6-dibromophenylacetamide followed by an in situ Suzuki cross-coupling reaction with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::134538aededd63b090691f9309c6ca8a
https://doi.org/10.1002/chin.200640116
https://doi.org/10.1002/chin.200640116
Autor:
Martin Berkheij, Dennis J. den Boer, Claudia Sewing, Jan H. van Maarseveen, Wouter I. Iwema Bakker, Jan Willem Terpstra, Lisan van der Sluis, Henk Hiemstra, Adri van den Hoogenband
Publikováno v:
Tetrahedron Letters, 46(14), 2369-2371. Elsevier
A novel efficient synthetic route towards the pharmaceutically relevant 2-substituted piperazine class is described. The key step involves α-lithiation of N-Boc piperazines, followed by reaction with several electrophiles. To obtain high yields, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a8e56d8273e7515b33df40890bb4f13
https://doi.org/10.1002/chin.200530146
https://doi.org/10.1002/chin.200530146
Autor:
Adri van den Hoogenband, Sander S. van Berkel, Moniek Tromp, Jan Willem Terpstra, Piet W. N. M. van Leeuwen, Gino P. F. van Strijdonck
Publikováno v:
Tetrahedron Letters, 45(41), 7659-7662. Elsevier
The coupling of arylboronic acids with imidazole in the presence of binuclear bis-μ-hydroxy copper(II) complexes is reported. The reactions can be performed in air as well as under nitrogen atmosphere. Reactions are carried out at ambient temperatur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93a192e240fd0d565a9519eb9bb6f209
https://dare.uva.nl/personal/pure/en/publications/basefree-anaerobic-cuiicatalyzed-arylnitrogen-bond-formations(aafb0e75-dfc2-442c-aba8-8457795f8b56).html
https://dare.uva.nl/personal/pure/en/publications/basefree-anaerobic-cuiicatalyzed-arylnitrogen-bond-formations(aafb0e75-dfc2-442c-aba8-8457795f8b56).html
Publikováno v:
Tetrahedron Letters, 22(50), 5097-5100. PERGAMON-ELSEVIER SCIENCE LTD
Selected ortho-disubstituted pyridines and thiopenes react with Michael acceptors to give functionalized quinolines or benzo[b]thiopenes, respectively.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bfde0dd4bd8e3b99182958383f3a059
https://research.rug.nl/en/publications/6af5100f-db61-4998-ab4e-25e3934b22c6
https://research.rug.nl/en/publications/6af5100f-db61-4998-ab4e-25e3934b22c6