Zobrazeno 1 - 10
of 260
pro vyhledávání: '"Jan Weber"'
Autor:
Nadine Janis Pohontsch, Jan Weber, Stephanie Stiel, Franziska Schade, Friedemann Nauck, Janina Timm, Martin Scherer, Gabriella Marx
Publikováno v:
BMC Primary Care, Vol 25, Iss 1, Pp 1-9 (2024)
Abstract Background Chronic, non-malignant diseases (CNMD) like chronic obstructive pulmonary disease (COPD), congestive heart failure (CHF) and dementia in advanced stages are very burdensome for patients. Timely palliative care with strong collabor
Externí odkaz:
https://doaj.org/article/969b94bfac5d4a688b12f76a7663b162
Autor:
Ebru Aydin, Silke Schreiner, Jacqueline Böhme, Birte Keil, Jan Weber, Bojan Žunar, Timo Glatter, Cornelia Kilchert
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract mRNA biogenesis in the eukaryotic nucleus is a highly complex process. The numerous RNA processing steps are tightly coordinated to ensure that only fully processed transcripts are released from chromatin for export from the nucleus. Here, w
Externí odkaz:
https://doaj.org/article/3fbb9ea2bfe447e5baf932641fa8afde
Autor:
Jianliang Gong, Chun-Yin Or, Eric Tung-Po Sze, Sidney Man-Ngai Chan, Pak-Long Wu, Peggy Miu-Yee Poon, Anthony K. Y. Law, Lucie Ulrychová, Jan Hodek, Jan Weber, Hui Ouyang, My Yang, Stephanie M. Eilts, Montserrat Torremorell, Yaakov Knobloch, Christopher J. Hogan, Christine Atallah, Juliette Davies, John Winkler, Ryan Gordon, Reza Zarghanishiraz, Mojtaba Zabihi, Cole Christianson, Deanne Taylor, Alan Rabinowitz, Jared Baylis, Joshua Brinkerhoff, Jonathan P. Little, Ri Li, Jeanne Moldenhauer, Michael K. Mansour
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 9 (2024)
ABSTRACT Infection control measures to prevent viral and bacterial infection spread are critical to maintaining a healthy environment. Pathogens such as viruses and pyogenic bacteria can cause infectious complications. Viruses such as SARS-CoV-2 are
Externí odkaz:
https://doaj.org/article/2aad4202781b4442825e694ebf9d28e3
Delivery of N-heterocyclic drugs, acids, phenols, and thiols via Tailor−made Self−immolative linkers
Autor:
Vahid Barati, Anna Hruzíková, Eliška Procházková, Martin Zavřel, Jaroslav Kozák, Jana Trylčová, Dominik Rejman, Jan Weber, Kateřina Bogdanová, Milan Kolář, Ondřej Baszczyňski
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 12, Iss , Pp 100216- (2024)
Heterocyclic drugs display diverse pharmacological activities and metabolic stability. However, their poor solubility and pharmacokinetic properties often compromise bioavailability and clinical outcomes. Nevertheless, the prodrug approach provides a
Externí odkaz:
https://doaj.org/article/02da55a35360455dbc11c50a0c3d790f
Autor:
Hoang Yen Nguyenova, Marie Hubalek Kalbacova, Marcela Dendisova, Miriama Sikorova, Jaroslava Jarolimkova, Zdenka Kolska, Lucie Ulrychova, Jan Weber, Alena Reznickova
Publikováno v:
Heliyon, Vol 10, Iss 9, Pp e30601- (2024)
Stability and cytotoxicity of PEGylated Au NPs is crucial for biomedical application. In this study, we have focused on thermal stability of PEGylated Au NPs at 4 and 37 °C and after sterilization in autoclave. Gold nanoparticles were prepared by di
Externí odkaz:
https://doaj.org/article/4d47922eae7e49e680b3c7a983a4bf38
Autor:
Jan Weber, Anne-Kristin Solbakk, Alejandro O. Blenkmann, Anais Llorens, Ingrid Funderud, Sabine Leske, Pål Gunnar Larsson, Jugoslav Ivanovic, Robert T. Knight, Tor Endestad, Randolph F. Helfrich
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Contextual cues and prior evidence guide human goal-directed behavior. The neurophysiological mechanisms that implement contextual priors to guide subsequent actions in the human brain remain unclear. Using intracranial electroencephalograph
Externí odkaz:
https://doaj.org/article/9d35870273aa4dc5882bad10f4a1e30b
Autor:
Eszter Boglárka Lőrincz, Gergely Tóth, Júlia Spolárics, Mihály Herczeg, Jan Hodek, István Zupkó, Renáta Minorics, Dorottya Ádám, Attila Oláh, Christos C. Zouboulis, Jan Weber, Lajos Nagy, Eszter Ostorházi, Ildikó Bácskay, Anikó Borbás, Pál Herczegh, Ilona Bereczki
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-20 (2023)
Abstract (−)-Cannabidiol (CBD) and (−)-cannabigerol (CBG) are two major non-psychotropic phytocannabinoids that have many beneficial biological properties. However, due to their low water solubility and prominent first-pass metabolism, their oral
Externí odkaz:
https://doaj.org/article/5a9a372dc9b844a19bbb1a3fff919b53
Autor:
Sandra Žáčková, Marcela Pávová, Jana Trylčová, Jitka Chalupová, Anastasiia Priss, Ondřej Lukšan, Jan Weber
Publikováno v:
Cells, Vol 13, Iss 10, p 791 (2024)
Adhesion G protein-coupled receptors (aGPCRs) play an important role in neurodevelopment, immune defence and cancer; however, their role throughout viral infections is mostly unexplored. We have been searching for specific aGPCRs involved in SARS-CoV
Externí odkaz:
https://doaj.org/article/e28df66bff804be5adc544f42663c831
Autor:
Mikolaj Zmudzinski, Wioletta Rut, Kamila Olech, Jarosław Granda, Mirosław Giurg, Małgorzata Burda-Grabowska, Rafał Kaleta, Michala Zgarbova, Renata Kasprzyk, Linlin Zhang, Xinyuanyuan Sun, Zongyang Lv, Digant Nayak, Malgorzata Kesik-Brodacka, Shaun K. Olsen, Jan Weber, Rolf Hilgenfeld, Jacek Jemielity, Marcin Drag
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Proteases encoded by SARS-CoV-2 constitute a promising target for new therapies against COVID-19. SARS-CoV-2 main protease (Mpro, 3CLpro) and papain-like protease (PLpro) are responsible for viral polyprotein cleavage—a process crucial for
Externí odkaz:
https://doaj.org/article/01362b97d3a24b76b811f51a8665c29d
Autor:
Andreas Günther, Sybille Schmid, Uta Weidlich-Wichmann, Eileen Czaputa, Martina Hasseler, Jan Weber
Publikováno v:
Resuscitation Plus, Vol 16, Iss , Pp 100508- (2023)
Aim: The realities of emergency care and resuscitation research involving nursing home (NH) residents suggest an overuse of resuscitation attempts in NHs. A complete analysis of all NH resident deaths is needed to provide a complementary perspective
Externí odkaz:
https://doaj.org/article/c948fb440f524ea58a790639cf2ecb8a