Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jan W. van Nispen"'
Autor:
Thijs de Boer, Chris L.E. Broekkamp, Jan W. van Nispen, Jane M. L. van der Werf‐Pieters, Pedro H. H. Hermkens, Harry C. J. Ottenheijm
Publikováno v:
Recueil des Travaux Chimiques des Pays-Bas. 112:95-106
The design cycle of peptidomimetics having CCK-A agonistic activity is discussed. The phases of this strategic approach are discussed briefly and results obtained either in our laboratories or by other groups are elaborated in this framework. Most of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b165738c495cb3b0a8ae536671c8538
https://doi.org/10.1002/recl.19931120205
https://doi.org/10.1002/recl.19931120205
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 33:233-243
Methionine and cysteine containing peptides can be labelled with 35S by coupling of 35S-cysteine or 35S-methionine with a large excess of suitably protected peptide precursors. This is illustrated for [pGlu4, Cyt6]AVP-(4-9), β-endorphin-(5-17) and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b1de9ae6f3e5e764ffe2a76cebc05f1
https://doi.org/10.1002/jlcr.2580330309
https://doi.org/10.1002/jlcr.2580330309
Publikováno v:
Tetrahedron Letters. 32:6025-6028
A facile, one-pot synthesis of Nα-t-Butyloxycarbonyl,Nδ,Nϖ-di-benzyloxycarbonyl-L-Arginine (3a) and Nα,Nδ,Nϖ-tri-benzyloxycarbonyl-L-Arginine (3b) is reported. Nα-t-Butyloxycarbonyl-L-Arginine (1b) is treated with trimethylsilylchloride and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c63970ee22b4cf964e141647802f4444
https://doi.org/10.1016/s0040-4039(00)79455-x
https://doi.org/10.1016/s0040-4039(00)79455-x
Publikováno v:
Journal of Pharmaceutical Sciences. 80:46-49
Four specific and sensitive antisera against 9-desglycinamide-8-arginine vasopressin (DGAVP) were obtained by means of site-specific immunization in rabbits, using a Keyhole Limpet haemocyanin-DGAVP conjugate synthesized by a specific reaction of a t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6269e6b21343070b72ef0fdf42d94a83
https://doi.org/10.1002/jps.2600800112
https://doi.org/10.1002/jps.2600800112
Autor:
Mieke Jetten, Peter D. J. Grootenhuis, Harry C. J. Ottenheijm, Jan W. van Nispen, Co A.M. Peters, A. Visser
Publikováno v:
Bioorganicmedicinal chemistry. 3(8)
In a study to combine the transition state analogue concept with the principle of catalytic site spanning, a series of peptide-derived transition state analogue (TSA) inhibitors of thrombin has been synthesized and tested. In the sequence H-D-Phe-Pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f12390b6b29fb1f3c894d75fa4c2aadc
https://pubmed.ncbi.nlm.nih.gov/7582983
https://pubmed.ncbi.nlm.nih.gov/7582983
Autor:
Jeroen A.D.M. Tonnaer, Wouter J. Florijn, Thijs de Boer, Jan W. van Nispen, Dirk H.G. Versteeg
Publikováno v:
European journal of pharmacology. 207(1)
ACTH-(1-24) decreased the binding of the dopamine D 2 receptor agonist, [ 3 H]N-propylnorapomorphine ([ 3 H]NPA), to rat striatal membranes in a concentration-dependent manner, with a K i of 5 × 10 −7 M. Saturation curves for [ 3 H]NPA binding in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b96ccc43368c311700ff8cda102220ab
https://pubmed.ncbi.nlm.nih.gov/1680721
https://pubmed.ncbi.nlm.nih.gov/1680721
Autor:
Béla Bohus, Jan W. van Nispen, David de Wied, J. Peter H. Burbach, Gábor L. Kovács, H. M. Greven
Publikováno v:
European Journal of Pharmacology. 94:125-131
An oxytocin fragment which accumulated during the incubation of oxytocin with brain synaptic membranes was chemically characterized as the hexapeptide pGlu-Asn-Cys(Cys)-Pro-Leu-Gly-NH2 [( pGlu4, Cyt6]OXT-(4-9]. This peptide was approximately a hundre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eebbb249e1d4513259b3dc540a973def
https://doi.org/10.1016/0014-2999(83)90449-1
https://doi.org/10.1016/0014-2999(83)90449-1
Publikováno v:
Collection of Czechoslovak Chemical Communications. 53:2537-2541
The feasibility of the synthesis of assymetric disulfide-containing peptides on solid phase resins was investigated. Using a fragment of [8-arginine]vasopressin as a model, the conversion of the S-acetamidomethylcysteine-containing peptide-resin into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c8b6c176299e918454e370f3b26ae94
https://doi.org/10.1135/cccc19882537
https://doi.org/10.1135/cccc19882537
Autor:
Jan W. van Nispen, Roger M Pinder
Publisher Summary Synaptic communication was long thought to be mediated solely by classical neurotransmitters such as monoamines, amino acids and acetylcholine. In the last decade, however, an increasing number of peptides have been found in CIS neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::937681f1c4c620df9ad24186500b3775
https://doi.org/10.1016/s0065-7743(08)61116-1
https://doi.org/10.1016/s0065-7743(08)61116-1
Publikováno v:
Biochemical and biophysical research communications. 98(2)
Met-enkephalin, injected i.p. 5 minutes before training, decreased acquisition of a step-up active avoidance response in rats. ACTH4–10 exerted a similar effect if given i.p. within 15 minutes of training. ACTH4–10 and Met-enkephalin share a phen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e8ff46d78362e37146a486e5916961a
https://pubmed.ncbi.nlm.nih.gov/6261739
https://pubmed.ncbi.nlm.nih.gov/6261739