Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jan Vomacka"'
Autor:
Fabian Koczian, Olga Nagło, Jan Vomacka, Binje Vick, Phil Servatius, Themistoklis Zisis, Britta Hettich, Uli Kazmaier, Stephan A. Sieber, Irmela Jeremias, Stefan Zahler, Simone Braig
Publikováno v:
Haematologica, Vol 104, Iss 3 (2019)
Combination chemotherapy has proven to be a favorable strategy to treat acute leukemia. However, the introduction of novel compounds remains challenging and is hindered by a lack of understanding of their mechanistic interactions with established dru
Externí odkaz:
https://doaj.org/article/1c116d8e9a6c4e9e97dc21f8d511861f
Autor:
Katharina Beck, Angelo Vedani, Wolfgang Heydenreuter, Jan Vomacka, Lydia Barth, Martin Smieško, Alex Odermatt, Petra Strajhar, Erika A. Crane, Karl Gademann, Elma Mons, Markus Neuburger, Stephan A. Sieber
To identify new potential therapeutic targets for neurodegenerative diseases, we initiated activity-based protein profiling studies with withanolide A (WitA), a known neuritogenic constituent of Withania somnifera root with unknown mechanism of actio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74ce6482be808c6fa2a578d3852dd4bd
https://www.zora.uzh.ch/id/eprint/196514/
https://www.zora.uzh.ch/id/eprint/196514/
Autor:
Franziska A. Mandl, Stephan A. Sieber, Klaus Richter, Ilke Ugur, Christian Fetzer, Iris Antes, Jan Vomacka, Volker C. Kirsch, Thilo M. Fuchs, Sabine Schneider, Elena Kunold
Publikováno v:
Angewandte Chemie International Edition. 55:14852-14857
Gram-negative bacteria represent a challenging task for antibacterial drug discovery owing to their impermeable cell membrane and restricted uptake of small molecules. We herein describe the synthesis of natural-product-derived epoxycyclohexenones an
Autor:
Elena Kunold, Klaus Richter, Ilke Ugur, Iris Antes, Jan Vomacka, Volker C. Kirsch, Stephan A. Sieber, Franziska A. Mandl, Thilo M. Fuchs, Christian Fetzer, Sabine Schneider
Publikováno v:
Angewandte Chemie. 128:15074-15079
Aufgrund ihrer undurchlassigeren Zellmembran und der damit verbundenen eingeschrankten Aufnahme von niedermolekularen Verbindungen stellen Gram-negative Bakterien eine grose Herausforderung fur die Entwicklung neuer Antibiotika dar. Hier wurden natur
Autor:
Martin H. Kunzmann, Stephan A. Sieber, Thomas Böttcher, Joanna Krysiak, Oliver Baron, Franziska Weinandy, Jan Vomacka, Katrin Lorenz-Baath, Vadim S. Korotkov, Bianca Bauer
Publikováno v:
Chemistry - A European Journal. 22:1622-1630
Methicillin-resistant Staphylococcus aureus (MRSA) causes severe infections with only few effective antibiotic therapies currently available. To approach this challenge, chemical entities with a novel and resistance-free mode of action are desperatel
Autor:
Klaus Richter, Marie-Theres Vielberg, Markus Lakemeyer, Vadim S. Korotkov, Martin L. Stein, Herbert Waldmann, Axel Pahl, Jan Vomacka, Christian Fetzer, Mathias W. Hackl, Michael Groll, Katrin Lorenz-Baath, Stephan A. Sieber
Publikováno v:
Angewandte Chemie. 127:16121-16126
Autor:
Markus Lakemeyer, Stephan A. Sieber, Matthias Stahl, Jan Vomacka, Joanna Krysiak, Christian Fetzer, Anja Fux
Publikováno v:
Journal of proteome research. 16(3)
β-Lactones have recently been introduced as the first selective ClpP inhibitors that attenuate virulence of both sensitive Staphylococcus aureus and multiresistant strains (MRSA). Although previous knockout studies showed that ClpP is essential for
Autor:
Jan Vomacka, Patrick C. Rämer, Norbert Reiling, Ulrike Protzer, Knud Esser, Johannes Lehmann, Katharina Kolbe, Stephan A. Sieber, Matthew B. Nodwell
Publikováno v:
MedChemComm 7, 1797-1801 (2016)
Lalistat inhibits growth of Mycobacterium tuberculosis in bacterial culture as well as in infected macrophages. Target identification by quantitative proteomics revealed a cluster of 20 hydrolytic proteins including members of the lipase family. Lipa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad48a987f2cd16e1d9c3a8e12a68850b
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=49794
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=49794
Autor:
Martin L. Stein, Christian Fetzer, Michael Groll, Jan Vomacka, Stephan A. Sieber, Klaus Richter, Herbert Waldmann, Mathias W. Hackl, Katrin Lorenz-Baath, Axel Pahl, Markus Lakemeyer, Vadim S. Korotkov, Marie-Theres Vielberg
Publikováno v:
Angewandte Chemie (International ed. in English). 54(52)
Caseinolytic protease P (ClpP) is an important regulator of Staphylococcus aureus pathogenesis. A high-throughput screening for inhibitors of ClpP peptidase activity led to the identification of the first non-covalent binder for this enzyme class. Co