Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jan Vincent V. Arafiles"'
Autor:
Masashi Kuriyama, Hisaaki Hirose, Toshihiro Masuda, Masachika Shudou, Jan Vincent V. Arafiles, Miki Imanishi, Masashi Maekawa, Yuji Hara, Shiroh Futaki
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/c2b128eeac154be18a9f286cef64caaa
Autor:
Yuna Nakagawa, Jan Vincent V. Arafiles, Yoshimasa Kawaguchi, Ikuhiko Nakase, Hisaaki Hirose, Shiroh Futaki
Publikováno v:
Bioconjugate Chemistry. 33:869-880
Macropinocytosis is a form of endocytosis that allows massive uptake of extracellular materials and is a promising route for intracellular delivery of biofunctional macromolecules and nanoparticles. Our laboratory developed a potent macropinocytosis-
Autor:
Yuki Nagano, Jan Vincent V. Arafiles, Keiko Kuwata, Yoshimasa Kawaguchi, Miki Imanishi, Hisaaki Hirose, Shiroh Futaki
Publikováno v:
Molecular Pharmaceutics. 19(2):558-567
Stapled peptides are a promising class of conformationally restricted peptides for modulating protein-protein interactions (PPIs). However, the low membrane permeability of these peptides is an obstacle to their therapeutic applications. It is common
Autor:
Kentarou Sakamoto, Hiroto Furukawa, Jan Vincent V. Arafiles, Miki Imanishi, Kazunori Matsuura, Shiroh Futaki
Publikováno v:
Bioconjugate Chemistry. 33:311-320
Nanocarriers that deliver functional proteins to cell interiors are an attractive platform for the intracellular delivery of intact proteins without further modification, with in vivo compatibility. Development of efficient methods for cargo protein
Autor:
Shiroh Futaki, Yusuke Hirai, Takahiro Iwata, Kentarou Sakamoto, Jan Vincent V. Arafiles, Hisaaki Hirose, Misao Akishiba, Miki Imanishi
Publikováno v:
Angewandte Chemie. 133:19957-19965
Fc region binding peptide conjugated with attenuated cationic amphiphilic lytic peptide L17E trimer [FcB(L17E)₃] was designed for immunoglobulin G (IgG) delivery into cells. Particle-like liquid droplets were generated by mixing Alexa Fluor 488 lab
Publikováno v:
Chemical communications (Cambridge, England). 58(60)
We report an efficient method to install electrophilic cysteine-selective ethynyl-phosphonamidates on peptides during Fmoc-based solid phase peptide synthesis (SPPS). By performing Staudinger-phosphonite reactions between different solid supported az
Autor:
Shiroh Futaki, Khongorzul Gerelbaatar, Takashi Morii, Eiji Nakata, Zhengxiao Zhang, Hisaaki Hirose, Jan Vincent V. Arafiles
Publikováno v:
Chemical Science
Realtime monitoring of the cellular environment, such as the intracellular pH, in a defined cellular space provides a comprehensive understanding of the dynamics processes in a living cell. Considering the limitation of spatial resolution in conventi
Autor:
Shiroh Futaki, Masashi Kuriyama, Maxwell M. Sakyiamah, Kazuhiro Sonomura, Jan Vincent V. Arafiles, Miki Imanishi, Hirokazu Tamamura, Akira Otaka, Wataru Nomura, Hisaaki Hirose, Yusuke Hirai
Publikováno v:
Angewandte Chemie International Edition. 60:11928-11936
Macropinocytosis is among ubiquitous cellular uptake mechanisms of peptide-based intracellular delivery. Due to its capability of engulfing large macromolecules, macropinocytosis shows promise as a route for the intracellular uptake of biomacromolecu
Autor:
Masashi Kuriyama, Hisaaki Hirose, Toshihiro Masuda, Masachika Shudou, Jan Vincent V. Arafiles, Miki Imanishi, Masashi Maekawa, Yuji Hara, Shiroh Futaki
Publikováno v:
Scientific Reports. 12
Macropinocytosis is a type of endocytosis accompanied by actin rearrangement-driven membrane deformation, such as lamellipodia formation and membrane ruffling, followed by the formation of large vesicles, macropinosomes. Ras-transformed cancer cells
Autor:
Shiroh Futaki, Jan Vincent V. Arafiles
Publikováno v:
Nature Chemistry. 13:517-519
The cell membrane acts as a border that restricts uptake of extracellular proteins. Now, peptide chemists have developed two new approaches for transporting functional and biologically relevant proteins across the cellular border by anchoring cyclic