First independent validation of the proton-boron capture therapy concept

Autor: Anna Jelínek Michaelidesová, Pavel Kundrát, Oldřich Zahradníček, Irina Danilová, Kateřina Pachnerová Brabcová, Jana Vachelová, Jan Vilimovský, Miroslav David, Vladimír Vondráček, Marie Davídková

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)

Abstract Boron has been suggested to enhance the biological effectiveness of proton beams in the Bragg peak region via the p + 11B → 3α nuclear capture reaction. However, a number of groups have observed no such enhancement in vitro or questioned

Externí odkaz: https://doaj.org/article/9ecbd0e4170f4b8a94c34aabe5128c1a

Continuous Flow Biocatalytic Reductive Amination by Co‐Entrapping Dehydrogenases with Agarose Gel in a 3D‐Printed Mould Reactor

Autor: Federico Croci, Jan Vilím, Theodora Adamopoulou, Vasilis Tseliou, Peter J. Schoenmakers, Tanja Knaus, Francesco G. Mutti

Publikováno v: ChemBioChem, 23(22):e202200549. Wiley-VCH Verlag

Herein, we show how the merge of biocatalysis with flow chemistry aided by 3D-printing technologies can facilitate organic synthesis. This concept was exemplified for the reductive amination of benzaldehyde catalysed by co-immobilised amine dehydroge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f6b56c39e54782e4ca197a3cc4c5812
https://doi.org/10.1002/cbic.202200549

Synthetic Evidence of the Amadori-Type Alkylation of Biogenic Amines by the Neurotoxic Metabolite Dopegal

Autor: Ed Zuidinga, Martin J. Wanner, Jan H. van Maarseveen, Dorette S. Tromp, Jan Vilím, Steen Ingemann Jørgensen

Publikováno v: The Journal of Organic Chemistry
Journal of Organic Chemistry, 85(2), 1202-1207. American Chemical Society

The neurotransmitter metabolite 3,4-dihydroxy-phenylglycolaldehyde (dopegal) damages neurons and the myocardium by protein cross-linking, resulting in conglomerations and cell death. We investigated this process on a synthetic scale, leading to the d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc413d28a834e2bc52a78c31ee11849
https://doi.org/10.1021/acs.joc.9b01948

Catalytic Promiscuity of Galactose Oxidase: A Mild Synthesis of Nitriles from Alcohols, Air, and Ammonia

Autor: Jan Vilím, Tanja Knaus, Francesco G. Mutti

Publikováno v: Angewandte Chemie (International Ed. in English)
Angewandte Chemie, 130(43), 14436-14440. John Wiley and Sons Ltd
Angewandte Chemie International Edition
Angewandte Chemie, International Edition, 57(43), 14240-14244. John Wiley and Sons Ltd

We report an unprecedented catalytically promiscuous activity of the copper‐dependent enzyme galactose oxidase. The enzyme catalyses the one‐pot conversion of alcohols into the related nitriles under mild reaction conditions in ammonium buffer, c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::406ff4785518b28261302f7293fce815
https://hdl.handle.net/11245.1/dd0c68f5-5c18-4250-8ef5-792227e1ee84

The ALDH21 gene found in lower plants and some vascular plants codes for a NADP(+) -dependent succinic semialdehyde dehydrogenase

Autor: Radka Končitíková, Armelle Vigouroux, David Kopečný, Lenka Jašková, Jan Vilím, Martina Kopečná, Klaus von Schwartzenberg, Eva Hajkova, Solange Moréra, Pierre Briozzo, Marek Šebela

Publikováno v: The Plant Journal: For Cell and Molecular Biology
The Plant Journal: For Cell and Molecular Biology, 2017, 92 (2), pp.229-243. ⟨10.1111/tpj.13648⟩

Lower plant species including some green algae, non-vascular plants (bryophytes) as well as the oldest vascular plants (lycopods) and ferns (monilophytes) possess a unique aldehyde dehydrogenase (ALDH) gene named ALDH21, which is upregulated during d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3398a171b335be53b27415a2eaff275
https://hal.archives-ouvertes.fr/hal-02389777