Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Jan Verhoeff"'
Autor:
Lynn van Olst, Alwin Kamermans, Sem Halters, Susanne M. A. van der Pol, Ernesto Rodriguez, Inge M. W. Verberk, Sanne G. S. Verberk, Danielle W. R. Wessels, Carla Rodriguez-Mogeda, Jan Verhoeff, Dorine Wouters, Jan Van den Bossche, Juan J. Garcia-Vallejo, Afina W. Lemstra, Maarten E. Witte, Wiesje M. van der Flier, Charlotte E. Teunissen, Helga E. de Vries
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-21 (2024)
Abstract Background Alzheimer’s disease (AD) is the most frequent cause of dementia. Recent evidence suggests the involvement of peripheral immune cells in the disease, but the underlying mechanisms remain unclear. Methods We comprehensively mapped
Externí odkaz:
https://doaj.org/article/bbeaac8f21914591a0b29202e34aed6d
Autor:
Job Saris, Sanne Bootsma, Jan Verhoeff, Jurriaan B. Tuynman, Manon E. Wildenberg, Esther Siteur-van Rijnstra, Kristiaan J. Lenos, Juan J. Garcia Vallejo, Louis Vermeulen, Joep Grootjans
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundThe occurrence of peritoneal metastasis (PM) in patients with colorectal cancer (CRC) has a dismal prognosis. There is often limited response to systemic- and immunotherapy, even in microsatellite unstable (MSI) CRC. To overcome therapy res
Externí odkaz:
https://doaj.org/article/0db70c82f5d3425981c96647ff398c29
Autor:
Sophie A. Dusoswa, Jan Verhoeff, Saskia van Asten, Joyce Lübbers, Marlous van den Braber, Sophie Peters, Sanne Abeln, Matheus H.W. Crommentuijn, Pieter Wesseling, William Peter Vandertop, Jos W. R. Twisk, Thomas Würdinger, David Noske, Yvette van Kooyk, Juan J. Garcia-Vallejo
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundGlioblastomas manipulate the immune system both locally and systemically, yet, glioblastoma-associated changes in peripheral blood immune composition are poorly studied. Age and dexamethasone administration in glioblastoma patients have bee
Externí odkaz:
https://doaj.org/article/60114ef332f047a9a98da36bc515e04a
Autor:
Tom D. Y. Reijnders, Alex R. Schuurman, Jan Verhoeff, Marlous van den Braber, Renée A. Douma, Daniël R. Faber, Alberta G. A. Paul, W. Joost Wiersinga, Anno Saris, Juan J. Garcia Vallejo, Tom van der Poll
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundCommunity-acquired pneumonia (CAP) represents a major health burden worldwide. Dysregulation of the immune response plays an important role in adverse outcomes in patients with CAP.MethodsWe analyzed peripheral blood mononuclear cells by 36
Externí odkaz:
https://doaj.org/article/1c395277784f45d4a2292698566e39b7
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-15 (2022)
Abstract Background Current methods of high-dimensional unsupervised clustering of mass cytometry data lack means to monitor and evaluate clustering results. Whether unsupervised clustering is correct is typically evaluated by agreement with dimensio
Externí odkaz:
https://doaj.org/article/06240bb5478c4d44a0302085c8399d54
Autor:
Manon de Krijger, Ishtu L. Hageman, Andrew Y. F. Li Yim, Jan Verhoeff, Juan J. Garcia Vallejo, Patricia H. P. van Hamersveld, Evgeni Levin, Theodorus B. M. Hakvoort, Manon E. Wildenberg, Peter Henneman, Cyriel Y. Ponsioen, Wouter J. de Jonge
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundPrimary sclerosing cholangitis (PSC) is a chronic inflammatory liver disease affecting the intra- and extrahepatic bile ducts, and is strongly associated with ulcerative colitis (UC). In this study, we explored the peripheral blood DNA meth
Externí odkaz:
https://doaj.org/article/ecb2a98c38e74c07ac01f6e645bbf90b
Autor:
Ahmed M. I. Elfiky, Ishtu L. Hageman, Marte A. J. Becker, Jan Verhoeff, Andrew Y. F. Li Yim, Vincent W. Joustra, Lieven Mulders, Ivan Fung, Inmaculada Rioja, Rab K. Prinjha, Nicholas N. Smithers, Rebecca C. Furze, Palwinder K. Mander, Matthew J. Bell, Christianne J. Buskens, Geert R. D’Haens, Manon E. Wildenberg, Wouter J. de Jonge
Publikováno v:
Cells, Vol 11, Iss 18, p 2846 (2022)
Background: Myeloid cells are critical determinants of the sustained inflammation in Crohn’s Disease (CD). Targeting such cells may be an effective therapeutic approach for refractory CD patients. Bromodomain and extra-terminal domain protein inhib
Externí odkaz:
https://doaj.org/article/006cf9b280ac4952bda401939457b659
Autor:
Victor Cervera-Carrascon, Dafne C. A. Quixabeira, Joao M. Santos, Riikka Havunen, Ioanna Milenova, Jan Verhoeff, Camilla Heiniö, Sadia Zafar, Juan J. Garcia-Vallejo, Victor W. van Beusechem, Tanja D. de Gruijl, Aino Kalervo, Suvi Sorsa, Anna Kanerva, Akseli Hemminki
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Immune checkpoint inhibitors such as anti-PD-1 have revolutionized the field of oncology over the past decade. Nevertheless, the majority of patients do not benefit from them. Virotherapy is a flexible tool that can be used to stimulate and/or recrui
Externí odkaz:
https://doaj.org/article/83f20326145f4c23b1093abd1e916e0b
Autor:
Roxan F.C.P.A. Helderman, Daan R. Löke, Jan Verhoeff, Hans M. Rodermond, Gregor G.W. van Bochove, Menno Boon, Sanne van Kesteren, Juan J. Garcia Vallejo, H. Petra Kok, Pieter J. Tanis, Nicolaas A.P. Franken, Johannes Crezee, Arlene L. Oei
Publikováno v:
Cells, Vol 9, Iss 8, p 1775 (2020)
Cytoreductive surgery (CRS) followed by hyperthermic intraperitoneal chemotherapy (HIPEC) is a treatment with curative intent for peritoneal metastasis of colorectal cancer (CRC). Currently, there is no standardized HIPEC protocol: choice of drug, pe
Externí odkaz:
https://doaj.org/article/76bcb2b9a97843feaf72ac336c95b1d5
Autor:
Patricia van Hamersveld, Laura Tomlinson, Ishtu Hageman, Ahmed M. I. Elfiky, Sigrid E.M. Heinsbroek, Juan J. Garcia-Vallejo, Jan Verhoeff, Wouter J. de Jonge, Andrew Y. F. Li Yim, Matthew J Bell, Huw D. Lewis, Manon E. Wildenberg, Iris Admiraal, Rab K. Prinjha, Rebecca C. Furze, Richard Gregory, Mohammed Ghiboub, Palwinder K. Mander, Inmaculada Rioja, Manon de Krijger, Olaf Welting, Shafaque Rahman
Publikováno v:
Elfiky, A M I, Ghiboub, M, Li Yim, A Y F, Hageman, I L, Verhoeff, J, de Krijger, M, van Hamersveld, P H P, Welting, O, Admiraal, I, Rahman, S, Garcia-Vallejo, J J, Wildenberg, M E, Tomlinson, L, Gregory, R, Rioja, I, Prinjha, R K, Furze, R C, Lewis, H D, Mander, P K, Heinsbroek, S E M, Bell, M J & de Jonge, W J 2022, ' Carboxylesterase-1 Assisted Targeting of HDAC Inhibitors to Mononuclear Myeloid Cells in Inflammatory Bowel Disease ', Journal of Crohn's and Colitis, vol. 16, no. 4, pp. 668-681 . https://doi.org/10.1093/ecco-jcc/jjab176
Journal of Crohn's and Colitis, 16(4), 668-681. Elsevier
Journal of Crohn's & colitis, 16(4), 668-681. Elsevier
Journal of Crohn's and Colitis, 16(4), 668-681. Elsevier
Journal of Crohn's & colitis, 16(4), 668-681. Elsevier
Background and AimsHistone deacetylase inhibitors [HDACi] exert potent anti-inflammatory effects. Because of the ubiquitous expression of HDACs, clinical utility of HDACi is limited by off-target effects. Esterase-sensitive motif [ESM] technology aim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::082c0316620861e7964614f67286a50a
https://doi.org/10.1093/ecco-jcc/jjab176
https://doi.org/10.1093/ecco-jcc/jjab176