Adaptive immune changes associate with clinical progression of Alzheimer’s disease

Autor: Lynn van Olst, Alwin Kamermans, Sem Halters, Susanne M. A. van der Pol, Ernesto Rodriguez, Inge M. W. Verberk, Sanne G. S. Verberk, Danielle W. R. Wessels, Carla Rodriguez-Mogeda, Jan Verhoeff, Dorine Wouters, Jan Van den Bossche, Juan J. Garcia-Vallejo, Afina W. Lemstra, Maarten E. Witte, Wiesje M. van der Flier, Charlotte E. Teunissen, Helga E. de Vries

Publikováno v: Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-21 (2024)

Abstract Background Alzheimer’s disease (AD) is the most frequent cause of dementia. Recent evidence suggests the involvement of peripheral immune cells in the disease, but the underlying mechanisms remain unclear. Methods We comprehensively mapped

Externí odkaz: https://doaj.org/article/bbeaac8f21914591a0b29202e34aed6d

The immunological landscape of peripheral blood in glioblastoma patients and immunological consequences of age and dexamethasone treatment

Autor: Sophie A. Dusoswa, Jan Verhoeff, Saskia van Asten, Joyce Lübbers, Marlous van den Braber, Sophie Peters, Sanne Abeln, Matheus H.W. Crommentuijn, Pieter Wesseling, William Peter Vandertop, Jos W. R. Twisk, Thomas Würdinger, David Noske, Yvette van Kooyk, Juan J. Garcia-Vallejo

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

BackgroundGlioblastomas manipulate the immune system both locally and systemically, yet, glioblastoma-associated changes in peripheral blood immune composition are poorly studied. Age and dexamethasone administration in glioblastoma patients have bee

Externí odkaz: https://doaj.org/article/60114ef332f047a9a98da36bc515e04a

INFLECT: an R-package for cytometry cluster evaluation using marker modality

Autor: Jan Verhoeff, Sanne Abeln, Juan J. Garcia-Vallejo

Publikováno v: BMC Bioinformatics, Vol 23, Iss 1, Pp 1-15 (2022)

Abstract Background Current methods of high-dimensional unsupervised clustering of mass cytometry data lack means to monitor and evaluate clustering results. Whether unsupervised clustering is correct is typically evaluated by agreement with dimensio

Externí odkaz: https://doaj.org/article/06240bb5478c4d44a0302085c8399d54

A BET Protein Inhibitor Targeting Mononuclear Myeloid Cells Affects Specific Inflammatory Mediators and Pathways in Crohn’s Disease

Autor: Ahmed M. I. Elfiky, Ishtu L. Hageman, Marte A. J. Becker, Jan Verhoeff, Andrew Y. F. Li Yim, Vincent W. Joustra, Lieven Mulders, Ivan Fung, Inmaculada Rioja, Rab K. Prinjha, Nicholas N. Smithers, Rebecca C. Furze, Palwinder K. Mander, Matthew J. Bell, Christianne J. Buskens, Geert R. D’Haens, Manon E. Wildenberg, Wouter J. de Jonge

Publikováno v: Cells, Vol 11, Iss 18, p 2846 (2022)

Background: Myeloid cells are critical determinants of the sustained inflammation in Crohn’s Disease (CD). Targeting such cells may be an effective therapeutic approach for refractory CD patients. Bromodomain and extra-terminal domain protein inhib

Externí odkaz: https://doaj.org/article/006cf9b280ac4952bda401939457b659

Carboxylesterase-1 Assisted Targeting of HDAC Inhibitors to Mononuclear Myeloid Cells in Inflammatory Bowel Disease

Autor: Patricia van Hamersveld, Laura Tomlinson, Ishtu Hageman, Ahmed M. I. Elfiky, Sigrid E.M. Heinsbroek, Juan J. Garcia-Vallejo, Jan Verhoeff, Wouter J. de Jonge, Andrew Y. F. Li Yim, Matthew J Bell, Huw D. Lewis, Manon E. Wildenberg, Iris Admiraal, Rab K. Prinjha, Rebecca C. Furze, Richard Gregory, Mohammed Ghiboub, Palwinder K. Mander, Inmaculada Rioja, Manon de Krijger, Olaf Welting, Shafaque Rahman

Publikováno v: Elfiky, A M I, Ghiboub, M, Li Yim, A Y F, Hageman, I L, Verhoeff, J, de Krijger, M, van Hamersveld, P H P, Welting, O, Admiraal, I, Rahman, S, Garcia-Vallejo, J J, Wildenberg, M E, Tomlinson, L, Gregory, R, Rioja, I, Prinjha, R K, Furze, R C, Lewis, H D, Mander, P K, Heinsbroek, S E M, Bell, M J & de Jonge, W J 2022, ' Carboxylesterase-1 Assisted Targeting of HDAC Inhibitors to Mononuclear Myeloid Cells in Inflammatory Bowel Disease ', Journal of Crohn's and Colitis, vol. 16, no. 4, pp. 668-681 . https://doi.org/10.1093/ecco-jcc/jjab176
Journal of Crohn's and Colitis, 16(4), 668-681. Elsevier
Journal of Crohn's & colitis, 16(4), 668-681. Elsevier

Background and AimsHistone deacetylase inhibitors [HDACi] exert potent anti-inflammatory effects. Because of the ubiquitous expression of HDACs, clinical utility of HDACi is limited by off-target effects. Esterase-sensitive motif [ESM] technology aim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::082c0316620861e7964614f67286a50a
https://doi.org/10.1093/ecco-jcc/jjab176