Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Jan Vančo"'
Autor:
Barbora Vyhlídalová, Kristýna Krasulová, Petra Pečinková, Adéla Marcalíková, Radim Vrzal, Lenka Zemánková, Jan Vančo, Zdeněk Trávníček, Jan Vondráček, Martina Karasová, Sridhar Mani, Zdeněk Dvořák
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 7, p 2614 (2020)
We examined the effects of gut microbial catabolites of tryptophan on the aryl hydrocarbon receptor (AhR). Using a reporter gene assay, we show that all studied catabolites are low-potency agonists of human AhR. The efficacy of catabolites differed s
Externí odkaz:
https://doaj.org/article/04270e0b74804ce4a71a903df1898c26
Autor:
Kristýna Krasulová, Jan Vančo, Zdeněk Dvořák, Zdeněk Trávníček, Iveta Bartoňková, Barbora Vyhlídalová, Sridhar Mani, Karolína Poulíková
Publikováno v:
Toxicology letters. 313
Mono-methylindoles (MMI) were described as agonists and/or antagonists of the human aryl hydrocarbon receptor (AhR). Here, we investigated the effects of MMI on AhR-CYP1A pathway in human hepatocytes and HepaRG cells derived from human progenitor hep
Autor:
Viktor Brabec, Jan Vančo, Olga Novakova, Radka Křikavová, Jana Kasparkova, Zdeněk Trávníček, Hana Kostrhunova
Publikováno v:
Angewandte Chemie (International ed. in English). 54(48)
We report toxic effects of a photoactivatable platinum(IV) complex conjugated with suberoyl-bis-hydroxamic acid in tumor cells. The conjugate exerts, after photoactivation, two functions: activity as both a platinum(II) anticancer drug and histone de
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1314 (2023)
The effects of two anticancer active copper(II) mixed-ligand complexes of the type [Cu(qui)(mphen)]Y·H2O, where Hqui = 2-phenyl-3-hydroxy- 1H-quinolin-4-one, mphen = bathophenanthroline, and Y = NO3 (complex 1) or BF4 (complex 2) on the activities o
Externí odkaz:
https://doaj.org/article/3f0b4d22e590414d9dd82aed747689e3
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 307 (2023)
A series of six heteroleptic copper(II) complexes with 2′-hydroxy-4-(dimethylamino)chalcone (HL) with the composition [Cu(N-N)(L)]NO3 (1–6), where N-N stands for dmbpy = 5,5′-dimethyl-2,2′-bipyridine (1), bphen = 4,7-diphenyl-1,10-phenanthrol
Externí odkaz:
https://doaj.org/article/23d3c1c5a05144c8af08582652534d9d
Autor:
Zdeněk Trávníček, Ján Vančo, Jan Belza, Jan Hošek, Zdeněk Dvořák, René Lenobel, Igor Popa, Karel Šmejkal, Pavel Uhrin
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2293 (2023)
Motivated by the clinical success of gold(I) metallotherapeutic Auranofin in the effective treatment of both inflammatory and cancer diseases, we decided to prepare, characterize, and further study the [Au(kin)(PPh3)] complex (1), where Hkin = kineti
Externí odkaz:
https://doaj.org/article/32e26e30bb4d41c08111dbac4ab39590
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 14, p 7626 (2021)
A series of new heteroleptic copper(II) complexes of the composition [Cu(L)(bpy)]NO3·2MeOH (1), [Cu(L)(dimebpy)]NO3·2H2O (2), [Cu(L)(phen)]NO3·2MeOH (3), [Cu(L)(bphen)]NO3·MeOH (4), [Cu(L)(dppz)]NO3·MeOH (5) was prepared, where HL = 3-(3,4-dihyd
Externí odkaz:
https://doaj.org/article/9f6dbcf819b94946b64d06c3d92dd79e
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 5, Pp 9520-9539 (2015)
A series of anionic heavy lanthanide complexes, involving the N-salicylideneglycinato(2-) Schiff base ligand (salgly) and having the general formula K[Ln(salgly)2(H2O)2]∙H2O (1–6), where Ln stands for Gd, Tb, Dy, Ho, Er and Tm, was prepared using
Externí odkaz:
https://doaj.org/article/d6481eea137f4e9482110c8dde27b4b0
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181822 (2017)
We report in vitro and in vivo anti-inflammatory activities of a series of copper(II)-lawsone complexes of the general composition [Cu(Law)2(LN)x(H2O)(2-x)]·yH2O; where HLaw = 2-hydroxy-1,4-naphthoquinone, x = 1 when LN = pyridine (1) and 2-aminopyr
Externí odkaz:
https://doaj.org/article/126a4a9529064b6b8b183d6d95bd33e8
Autor:
Hana Michnová, Šárka Pospíšilová, Tomáš Goněc, Iva Kapustíková, Peter Kollár, Violetta Kozik, Robert Musioł, Izabela Jendrzejewska, Ján Vančo, Zdeněk Trávníček, Alois Čížek, Andrzej Bąk, Josef Jampílek
Publikováno v:
Molecules, Vol 24, Iss 16, p 2991 (2019)
A series of twenty-six methoxylated and methylated N-aryl-1-hydroxynaphthalene- 2-carboxanilides was prepared and characterized as potential anti-invasive agents. The molecular structure of N-(2,5-dimethylphenyl)-1-hydroxynaphthalene-2-carboxamide as
Externí odkaz:
https://doaj.org/article/884e86021aa640b5a4bf3ac1e04a6b7b