Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jan Ungewiss"'
Autor:
Maria Lucey, Philip Pickford, Stavroula Bitsi, James Minnion, Jan Ungewiss, Katja Schoeneberg, Guy A. Rutter, Stephen R. Bloom, Alejandra Tomas, Ben Jones
Publikováno v:
Molecular Metabolism, Vol 37, Iss , Pp 100991- (2020)
Objective: The objective of this study was to determine how pharmacokinetically advantageous acylation impacts on glucagon-like peptide-1 receptor (GLP-1R) signal bias, trafficking, anti-hyperglycaemic efficacy, and appetite suppression. Methods: In
Externí odkaz:
https://doaj.org/article/6622263a11a0409ea4a255d09f36f3b7
Autor:
Dirk Zboralski, Frank Osterkamp, Esben Christensen, Anne Bredenbeck, Anne Schumann, Aileen Hoehne, Eberhard Schneider, Matthias Paschke, Jan Ungewiss, Christian Haase, Liliane Robillard, Andrew D. Simmons, Thomas C. Harding, Minh Nguyen
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging.
Purpose FAP is a membrane-bound protease under investigation as a pan-cancer target, given its high levels in tumors but limited expression in normal tissues. FAP-2286 is a radiopharmaceutical in clinical development for solid tumors that consists of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdd4a37db504ea8cc30fd8827c34bb4f
https://doi.org/10.1007/s00259-023-06211-6
https://doi.org/10.1007/s00259-023-06211-6
Autor:
Dirk Zboralski, Aileen Hoehne, Anne Bredenbeck, Anne Schumann, Minh Nguyen, Eberhard Schneider, Jan Ungewiss, Matthias Paschke, Christian Haase, Jan L. von Hacht, Tanya Kwan, Kevin K. Lin, Jan Lenore, Thomas C. Harding, Jim Xiao, Andrew D. Simmons, Ajay-Mohan Mohan, Nicola Beindorff, Ulrich Reineke, Christiane Smerling, Frank Osterkamp
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 49:3651-3667
Purpose Fibroblast activation protein (FAP) is a membrane-bound protease that has limited expression in normal adult tissues but is highly expressed in the tumor microenvironment of many solid cancers. FAP-2286 is a FAP-binding peptide coupled to a r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4850c6231a32e27da84462b88a71eaaf
https://doi.org/10.1007/s00259-022-05842-5
https://doi.org/10.1007/s00259-022-05842-5
Autor:
James Minnion, Alejandra Tomas, Philip Pickford, Ben Jones, Guy A. Rutter, Jan Ungewiss, Katja Schoeneberg, Stephen R. Bloom, Maria Lucey
Publikováno v:
bioRxiv
ObjectiveTo determine how pharmacokinetically advantageous acylation impacts on glucagon-like peptide-1 receptor (GLP-1R) signal bias, trafficking, anti-hyperglycaemic efficacy and appetite suppression.MethodsIn vitro signalling responses were measur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fedd1c716a085ce9f42a303cde8d8708
https://doi.org/10.1101/855874
https://doi.org/10.1101/855874
Autor:
Philip Pickford, Guy A. Rutter, Alejandra Tomas, Stephen R. Bloom, James Minnion, Ben Jones, Katja Schoeneberg, Stavroula Bitsi, Jan Ungewiss, Maria Lucey
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 37, Iss, Pp 100991-(2020)
Molecular Metabolism, Vol 37, Iss, Pp 100991-(2020)
Objective The objective of this study was to determine how pharmacokinetically advantageous acylation impacts on glucagon-like peptide-1 receptor (GLP-1R) signal bias, trafficking, anti-hyperglycaemic efficacy, and appetite suppression. Methods In vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eea458e3c27345ef8e319b61a8f529f
https://pubmed.ncbi.nlm.nih.gov/32278079
https://pubmed.ncbi.nlm.nih.gov/32278079
Publikováno v:
Journal of pharmaceutical sciences. 108(3)
The plasma protein binding capability of drug substances represents an important assay parameter in drug discovery and development. For very strong plasma protein binding molecules, however, the free fraction in plasma f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7ee7f4cb8930db75b6cdb422fba7a561
https://pubmed.ncbi.nlm.nih.gov/30342006
https://pubmed.ncbi.nlm.nih.gov/30342006
Autor:
Hermann Fromme, Ludwig Gruber, Martin Schlummer, Sigrun Böhmer, Jan Ungewiss, Gerd Wolz, Angela Möller, Wolfgang Dekant, D Twardella, Richard Mayer, Bernhard Liebl
Publikováno v:
Environmental Science & Technology. 41:7928-7933
Because dietary intake is supposed to be an important route of human exposure we quantified the dietary intake of perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), perfluorohexane sulfonate (PFHxS), perfluorohexanoate (PFHxA), and perfluor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9ee50422b4efb546b1b541d280eab6
https://doi.org/10.1021/es071244n
https://doi.org/10.1021/es071244n
Autor:
Klaus-Peter Wittern, Claudius Rapp, Reiner Salzer, Hartmut Dr. Schmidt-Lewerkühne, Jan Ungewiß, Jens-Peter Vietzke
Publikováno v:
Analytical and Bioanalytical Chemistry. 381:1401-1407
Cationic polysaccharides containing N-hydroxypropyl-N,N,N-trimethylammonium substituents are widely used as conditioning agents for hair-care products. A sensitive method has been developed for the quantitation of these polymers. After acidic extract
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d99e76e0becfaee655d1a2813e69a595
https://doi.org/10.1007/s00216-005-3107-6
https://doi.org/10.1007/s00216-005-3107-6
Autor:
Simon Michaelis, Anna K. Schrey, Olivia Y. Graebner, Hubert Koester, Anne Diehl, Jenny J. Fischer, Sabine Horzowski, Mirko Glinski, Mathias Dreger, Friedrich Kroll, Jan Ungewiss
Publikováno v:
Proteomics. 11(20)
Suberoylanilide hydroxamic acid (SAHA) is a potent histone deacetylase (HDAC) inhibitor. Inhibitors of HDACs are used in cancer therapy based on the role HDACs play in transcription by regulating chromatin compaction and non-histone proteins such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbfabc2f22ad5971cf12d34e68f055dc
https://pubmed.ncbi.nlm.nih.gov/21898820
https://pubmed.ncbi.nlm.nih.gov/21898820
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