Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jan Tykvart"'
Autor:
Švitrigailė Grincevičienė, Daiva Vaitkienė, Daiva Kanopienė, Rasa Vansevičiūtė, Jan Tykvart, Artūras Sukovas, Joana Celiešiūtė, Ernesta Ivanauskaitė Didžiokienė, Arvydas Čižauskas, Aida Laurinavičienė, Vlastimil Král, Anna Hlavačková, Jitka Zemanová, Dovilė Stravinskienė, Aistė Sližienė, Agnė Petrošiūtė, Vytautas Petrauskas, Renata Balsytė, Jonas Grincevičius, Vaclav Navratil, Ullrich Jahn, Jan Konvalinka, Aurelija Žvirblienė, Daumantas Matulis, Jurgita Matulienė
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Precancerous lesions of human cervix uteri have a tendency for regression or progression. In cervical intraepithelial neoplasia grade 2 (CINII) case there is an uncertainty if a lesion will progress or regress. The carbonic anhydrase IX (CAI
Externí odkaz:
https://doaj.org/article/21f537fefc6c4782ad1d479862dddea8
Autor:
Tomáš Knedlík, Barbora Vorlová, Václav Navrátil, Jan Tykvart, František Sedlák, Šimon Vaculín, Miloslav Franěk, Pavel Šácha, Jan Konvalinka
Publikováno v:
FEBS Open Bio, Vol 7, Iss 9, Pp 1362-1378 (2017)
Glutamate carboxypeptidase II (GCPII), also known as prostate‐specific membrane antigen (PSMA) or folate hydrolase, is a metallopeptidase expressed predominantly in the human brain and prostate. GCPII expression is considerably increased in prostat
Externí odkaz:
https://doaj.org/article/289a58f040874623959efd5bfbca5e3c
Autor:
Jiří Brynda, Ullrich Jahn, Milan Potáček, Anna Hlavačková, Vlastimil Král, M. Kugler, Pavlína Řezáčová, Jiří Schimer, Milan Dejmek, Pavel Šácha, Jan Tykvart, Jan Konvalinka, Lukáš Tenora, Václav Navrátil, Jitka Zemanova, Pavel Majer
Publikováno v:
SLAS Discovery. 25:1026-1037
The DNA-linked inhibitor antibody assay (DIANA) has been recently validated for ultrasensitive enzyme detection and for quantitative evaluation of enzyme inhibitor potency. Here we present its adaptation for high-throughput screening of human carboni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e76834a8423743561d025c0c210238ea
https://doi.org/10.1177/2472555220918836
https://doi.org/10.1177/2472555220918836
Autor:
Pavel Šácha, Jan Konvalinka, Jan Tykvart, Václav Navrátil, Frantisek Sedlak, Miloslav Franěk, Tomáš Knedlík, Barbora Vorlová, Simon Vaculin
Publikováno v:
FEBS Open Bio
Glutamate carboxypeptidase II (GCPII), also known as prostate‐specific membrane antigen (PSMA) or folate hydrolase, is a metallopeptidase expressed predominantly in the human brain and prostate. GCPII expression is considerably increased in prostat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f2d1c3560a45abf1fa093ecd07e24b5
https://doi.org/10.1002/2211-5463.12276
https://doi.org/10.1002/2211-5463.12276
Autor:
Parama Pal, Srishti Garg, J. Stewart Aitchison, Frederic A. Fellouse, Edith M Hillan, James Jiahua Dou, Manoj M. Varma, Jan Tykvart, Sachdev S. Sidhu, Xilong Yuan, Anupriya Gopalsamy, Kevin de Haan
Publikováno v:
Biomed Opt Express
Dengue is one of the most rapidly spreading mosquito-borne viral diseases in the world. Differential diagnosis is a crucial step for the management of the disease and its epidemiology. Point-of-care testing of blood-borne dengue biomarkers provides a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f16d58621db108b7a8773abe54827747
https://doi.org/10.1364/boe.403803
https://doi.org/10.1364/boe.403803
Autor:
Jan Konvalinka, Václav Navrátil, Pavel Šácha, Jana Starková, Andrej Jančařík, Jiří Schimer, Pavel Majer, Karolína Šrámková, Jitka Bařinková, Jan Tykvart
Publikováno v:
Journal of Medicinal Chemistry. 58:4357-4363
We present here a structure-aided design of inhibitors targeting the active site as well as exosites of glutamate carboxypeptidase II (GCPII), a prostate cancer marker, preparing potent and selective inhibitors that are more than 1000-fold more activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3736f390dcb06f93a17ec9a7166b8d4a
https://doi.org/10.1021/acs.jmedchem.5b00278
https://doi.org/10.1021/acs.jmedchem.5b00278
Autor:
Pavel Šácha, Martin Hubálek, Jan Tykvart, Jan Konvalinka, Radko Souček, Cyril Bařinka, Jacek Lubkowski, Michal Svoboda, Václav Navrátil, Martin Hradilek
Publikováno v:
Journal of Biological Chemistry. 290:11321-11336
N-acetylated α-linked acidic dipeptidase-like protein (NAALADase L), encoded by the NAALADL1 gene, is a close homolog of glutamate carboxypeptidase II, a metallopeptidase that has been intensively studied as a target for imaging and therapy of solid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57fd5153e8ddb9ebbbea599239a94e34
https://doi.org/10.1074/jbc.m114.628149
https://doi.org/10.1074/jbc.m114.628149
Autor:
Jan Konvalinka, Jan Tykvart, Cyril Bařinka, F. Koukolík, Marco Colombatti, Pavel Šácha, Václav Navrátil, Eva Corey, Giulio Fracasso, Frantisek Sedlak
Publikováno v:
The Prostate. 74:1674-1690
BACKGROUND Prostate-specific membrane antigen (PSMA), also known as glutamate carboxypeptidase II (GCPII), is generally recognized as a diagnostic and therapeutic cancer antigen and a molecular address for targeted imaging and drug delivery studies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ad52541b1ee7ad463251d2cdbfac3db
https://doi.org/10.1002/pros.22887
https://doi.org/10.1002/pros.22887
Autor:
Pavel Majer, Pavel Šácha, Petr Pachl, Jan Tykvart, Lenka Poštová-Slavětínská, Jitka Bařinková, Jiří Schimer, Jan Konvalinka
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:4099-4108
Glutamate carboxypeptidase II (GCPII), also known as prostate specific membrane antigen (PSMA), is an established prostate cancer marker and is considered a promising target for specific anticancer drug delivery. Low-molecular-weight inhibitors of GC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41ae2879c7c355b36662eb0b1729be94
https://doi.org/10.1016/j.bmc.2014.05.061
https://doi.org/10.1016/j.bmc.2014.05.061
Autor:
Daniel J Toth, Martin Klima, Petr Man, Lenka Rezabkova, Rozálie Hexnerová, Adriana Baumlova, Vaclav Veverka, Evzen Boura, Nivedita Sengupta, Radim Nencka, Anna Dubankova, Dominika Chalupska, Jan Tykvart, Tamas Balla, Jana Humpolíčková
Publikováno v:
Scientific Reports
Phosphatidylinositol 4-kinase beta (PI4KB) is one of four human PI4K enzymes that generate phosphatidylinositol 4-phosphate (PI4P), a minor but essential regulatory lipid found in all eukaryotic cells. To convert their lipid substrates, PI4Ks must be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b8352c0c1082ac0cfa6d774174e0148
https://doi.org/10.1038/srep23641
https://doi.org/10.1038/srep23641