Drug development of an affinity enhanced, broadly neutralizing heavy chain-only antibody that restricts SARS-CoV-2 in rodents

Autor: Piet Maes, Martin Schwemmle, Allison Turner, Annette Ohnemus, Wander Van Breedam, Greetje Vande Velde, Bert Schepens, Sieglinde De Cae, Suzanne J.F. Kaptein, Nick Devoogdt, James Heads, Mark Ellis, Peter Staeheli, Gitte Michielsen, Bruno Dombrecht, Julius Beer, Dominique Tersago, Robbert Boudewijns, Sofie Jacobs, Leen Delang, Dries Van Herpe, João Paulo Portela Catani, Dirk Jochmans, Alistair Henry, Rana Abdelnabi, Nico Callewaert, Birgit Weynand, Sandrine Vanmarcke, Sarah Creytens, Simon Devos, George D. Moschonas, Isabel Remory, Annelies Van Hecke, Lana Langendries, Daniel Schnepf, Catelijne Stortelers, Koen Sedeyn, Ana Filipa Oliveira, Laura Seldeslachts, Xin Zhang, Xavier Saelens, Loes van Schie, Laurens Liesenborghs, Dorien De Vlieger, Chiara Lonigro, Frank Peelman, Massimiliano Germano, Joana Rocha-Pereira, Kevin Brady, Wannes Weyts, Hendrik Jan Tibaut, Sebastiaan ter Horst, Kai Dallmeier, Hannah Eeckhaut, Jackeline Cecilia Zavala Marchan, Kenny Roose, Johan Neyts, Wim Nerinckx, Daria Fijalkowska, Andy Popplewell, Iebe Rossey, Caroline Shi-Yan Foo, Jimmy Borloo

We have identified camelid single-domain antibodies (VHHs) that cross-neutralize SARS-CoV-1 and −2, such as VHH72, which binds to a unique highly conserved epitope in the viral receptor-binding domain (RBD) that is difficult to access for human ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d213f47d21cc67cf73c8fd52a12112a4
https://doi.org/10.1101/2021.03.08.433449

Acceleration of a BEM based solution of the velocity–vorticity formulation of the Navier–Stokes equations by the cross approximation method

Autor: Leopold Škerget, Jan Tibaut, Jure Ravnik

Publikováno v: Engineering Analysis with Boundary Elements. 82:17-26

In this paper, we present a method to decrease the computational demand of the boundary-domain integral equation based 3D flow solver. We focus on the solution of the velocity–vorticity formulation of the Navier–Stokes equation, which governs inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::73b71c5c8c4e7e5e1e9397121e6b60ea
https://doi.org/10.1016/j.enganabound.2017.05.013

An accelerated Boundary‐Domain Integral Method for three‐dimensional fluid flow analysis

Autor: Jure Ravnik, Jan Tibaut

Publikováno v: PAMM. 19

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e8b498b0ed97a15dfd85ab0895ad052
https://doi.org/10.1002/pamm.201900320

Stochastic modelling of nanofluids using the fast Boundary-Domain Integral Method

Autor: Jan Tibaut, Dragan Poljak, Jure Ravnik, Anna Susnjara, Mario Cvetković

In this paper, we couple a numerical method aimed at simulation of flow and heat transfer of nanofluids with stochastic modelling of input and material parameters. In order to simulate nanofluids, an in-house numerical method was developed, based on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ff85feb33e1210a20a15e1c9b6da01
https://doi.org/10.1016/j.enganabound.2019.07.014

NanoRound: A benchmark study on the numerical approach in nanofluids' simulation

Autor: Anna di Pasqua, Angel Huminic, Peter Farber, Niklas Wichmann, Jan Steffens, Sébastien Poncet, Ghofrane Sekrani, Jan Tibaut, Bernardo Buonomo, Jure Ravnik, Razvan Mahu, Gabriela Huminic, Oronzio Manca, Kavien Raaj Karpaiya, Cristina Oprea, Jonas Burggraf, Alina Adriana Minea, Davide Ercole

Publikováno v: International Communications in Heat and Mass Transfer. 108:104292

Numerical simulation of nanofluid flows is of maximum importance for a large area of applications, especially in the solar energy technology. Even though a lot of numerical studies are available in the open literature, there is still a large debate i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efb54688b393a04cb4e69159db41fa2e
https://doi.org/10.1016/j.icheatmasstransfer.2019.104292