Zobrazeno 1 - 10 of 215 pro vyhledávání: '"Jan Ter Meulen"'
1
Akademický článek
Novel intranasal vaccine targeting SARS-CoV-2 receptor binding domain to mucosal microfold cells and adjuvanted with TLR3 agonist Riboxxim™ elicits strong antibody and T-cell responses in mice
Autor: Dennis Horvath, Nigel Temperton, Martin Mayora-Neto, Kelly Da Costa, Diego Cantoni, Reinhold Horlacher, Armin Günther, Alexander Brosig, Jenny Morath, Barbara Jakobs, Marcus Groettrup, Heinz Hoschuetzky, Jacques Rohayem, Jan ter Meulen
Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract SARS-CoV-2 continues to circulate in the human population necessitating regular booster immunization for its long-term control. Ideally, vaccines should ideally not only protect against symptomatic disease, but also prevent transmission via
Externí odkaz: https://doaj.org/article/4520b07600b543c4bea38899ef4dcba3
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4
Akademický článek
Intratumoral expression of IL-12 from lentiviral or RNA vectors acts synergistically with TLR4 agonist (GLA) to generate anti-tumor immunological memory.
Autor: Jardin A Leleux, Tina C Albershardt, Rebecca Reeves, Reice James, Jordan Krull, Andrea J Parsons, Jan Ter Meulen, Peter Berglund
Publikováno v: PLoS ONE, Vol 16, Iss 12, p e0259301 (2021)
Systemic interleukin-12 (IL12) anti-tumor therapy is highly potent but has had limited utility in the clinic due to severe toxicity. Here, we present two IL12-expressing vector platforms, both of which can overcome the deficiencies of previous system
Externí odkaz: https://doaj.org/article/b0930d7daf3d499b8f67741020c6c439
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5
Akademický článek
A Phase 1b Study Evaluating the Safety, Tolerability, and Immunogenicity of CMB305, a Lentiviral-Based Prime-Boost Vaccine Regimen, in Patients with Locally Advanced, Relapsed, or Metastatic Cancer Expressing NY-ESO-1
Autor: Neeta Somaiah, Sant P. Chawla, Matthew S. Block, John C. Morris, Khanh Do, Joseph W. Kim, Mihaela Druta, Kamalesh K. Sankhala, Patrick Hwu, Robin L. Jones, Sacha Gnjatic, Seunghee Kim-Schulze, Kevin Tuballes, Mahlet Yishak, Hailing Lu, Adam Yakovich, Jan Ter Meulen, Michael Chen, Richard T. Kenney, Chet Bohac, Seth M. Pollack
Publikováno v: OncoImmunology, Vol 9, Iss 1 (2020)
Preclinical data suggest that a “prime-boost” vaccine regimen using a target-expressing lentiviral vector for priming, followed by a recombinant protein boost, may be effective against cancer; however, this strategy has not been evaluated in a cl
Externí odkaz: https://doaj.org/article/aeaf8cf7e6dc4867be463362683d875c
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6
Akademický článek
Double Lock of a Human Neutralizing and Protective Monoclonal Antibody Targeting the Yellow Fever Virus Envelope
Autor: Xishan Lu, Haixia Xiao, Shihua Li, Xuefei Pang, Jian Song, Sheng Liu, Huijun Cheng, Yan Li, Xiangxi Wang, Chaobin Huang, Tianling Guo, Jan ter Meulen, Stephane Daffis, Jinghua Yan, Lianpan Dai, Zihe Rao, Hans-Dieter Klenk, Jianxun Qi, Yi Shi, George F. Gao
Publikováno v: Cell Reports, Vol 26, Iss 2, Pp 438-446.e5 (2019)
Summary: Yellow fever virus (YFV), a deadly human pathogen, is the prototype of the genus Flavivirus. Recently, YFV re-emerged in Africa and Brazil, leading to hundreds of deaths, with some cases imported to China. Prophylactic or therapeutic counter
Externí odkaz: https://doaj.org/article/c3a5fa3ab3944365be3c35854778caa6
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