Výsledky vyhledávání - "Jan Teeuwsen"

On-line coupling of size exclusion and capillary zone electrophoresis via a reversed-phase C18 trapping column for the analysis of structurally related enkephalins in cerebrospinal fluid

Autor: Joop C. M. Waterval, G. Wiese, Gerhardus J. de Jong, Auke Bult, Jan Teeuwsen, Willy J. M. Underberg, Thom Stroink, H. Lingeman

Publikováno v: Electrophoresis, 24(5), 897-903. Wiley-VCH Verlag
Stroink, T, Wiese, G, Teeuwsen, J, Lingeman, H, Waterval, J C M, Bult, A, de Jong, G T & Underberg, W J M 2003, '
coupling of size exclusion and capillary zone electrophoresis via a reversed-phase C18 trapping column for the analysis of structurally related enkephalins in cerebrospinal fluid ', Electrophoresis, vol. 24, no. 5, pp. 897-903 . https://doi.org/10.1002/elps.200390113

On-line coupled analytical techniques can be advantageous in the assay of smaller peptides in complex biological matrices such as plasma, cerebrospinal fluid (CSF) and tissues. The present study shows the feasibility of a recently developed system, c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a604a76ef78b827e167b6bb40002fafc
https://doi.org/10.1002/elps.200390113

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On-line coupling of SEC and RP–LC for the determination of structurally related enkephalins in cerebrospinal fluid

Autor: Willy J. M. Underberg, Thom Stroink, H. Lingeman, Jan Teeuwsen, Joop C. M. Waterval, Auke Bult, G. Wiese, Gerhardus J. de Jong

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis, 30(4), 1393-401. Elsevier
Stroink, T, Wiese, G, Teeuwsen, J, Lingeman, H, Waterval, J C M, Bult, A, de Jong, G T & Underberg, W J M 2002, '
coupling of SEC and RP-LC for the determination of structurally related enkephalins in cerebrospinal fluid ', Journal of Pharmaceutical and Biomedical Analysis, vol. 30, no. 4, pp. 1393-401 . https://doi.org/10.1016/S0731-7085(02)00434-X

On-line coupled analytical techniques can be advantageous in the assay of smaller peptides in complex biological matrices such as plasma, cerebro-spinal fluid (CSF) and tissues. The present study shows the feasibility of the recently reported on-line

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ac67157d8e7e4571dccf6cff444248
https://doi.org/10.1016/s0731-7085(02)00434-x

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Comparison between transient isotachophoretic capillary zone electrophoresis and reversed-phase liquid chromatography for the determination of peptides in plasma

Autor: Willy J. M. Underberg, Joop C. M. Waterval, Hans Krabbe, Auke Bult, H. Lingeman, Jan Teeuwsen

Publikováno v: Electrophoresis, 20(14), 2909-2916. Wiley-VCH Verlag
Waterval, J C M, Krabbe, H, Teeuwsen, J, Bult, A, Lingeman, H & Underberg, W J M 1999, ' Comparison between transient isotachophoretic capillary zone electrophoresis and reversed-phase liquid chromatography for the determination of peptides in plasma ', Electrophoresis, vol. 20, no. 14, pp. 2909-2916 . https://doi.org/10.1002/(SICI)1522-2683(19991001)20:14<2909::AID-ELPS2909>3.0.CO;2-M

Low levels of peptide drugs in human plasma can be determined employing off-line solid-phase extraction, followed by capillary zone electrophoresis with UV detection. A bioanalytical procedure is presented, using gonadorelin and angiotensin II in hum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::320e7115398e11efcc8b2c4b03a6c24e
https://doi.org/10.1002/(sici)1522-2683(19991001)20:14<2909::aid-elps2909>3.0.co

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Qualitative and quantitative aspects of the degradation of several tripeptides derived from the antitumour peptide antagonist [Arg6, D-Trp7,9, MePhe8] substance P{6–11}

Autor: Mohamed Bouyakhrichan, Esther H.M Belshof, Jos H. Beijnen, Rianne J. van Maanen, Willy J. M. Underberg, Yunus Kellekule, Auke Bult, J.Léon E. Reubsaet, Ed Hop, Jan Teeuwsen

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 19:277-284

The tripeptides Arg-Trp-Phe, Arg-Trp-Phe-NH2, Phe-Trp-Arg and Phe-Trp-Arg-NH2 were subjected to a degradation study to get a more detailed insight into the degradation processes of the antitumor hexapeptide antagonist [Arg(6), D-Trp(7,9), MePhe(8)] s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baf4c0e2a5ab2de09e96f763745ae0ae
https://doi.org/10.1016/s0731-7085(98)00115-0

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Oxidation of recombinant methionyl human granulocyte colony stimulating factor

Autor: Auke Bult, Ed Hop, J.Léon E. Reubsaet, Serge D. Scholten, Willy J. M. Underberg, Jos H. Beijnen, Jan Teeuwsen

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 17:283-289

The oxidation of methionine residues in recombinant methionyl human granulocyte colony stimulating factor with hydrogen peroxide has been investigated. Kinetic data of the oxidation were obtained by using reversed phase-high performance liquid chroma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eaeb1f2e3f6ffd8a0989e9c9068f6d6
https://doi.org/10.1016/s0731-7085(97)00199-4

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Degradation Kinetics of Antagonist [Arg6, D-Trp7,9, MePhe8]-Substance-P {6-11} in Aqueous Solutions

Autor: W.J.M. Underberg, Jan Teeuwsen, O.A.G.J. Vanderhouwen, Jos H. Beijnen, A. Bult, E.H.M. Koster, J.L.E. Reubsaet

Publikováno v: Analytical Biochemistry. 227:334-341

Antagonist [Arg6, D-Trp7,9, MePhe8]-substance P {6-11} was subjected to a systematic stability study in which kinetic parameters were obtained for the degradation of this hexapeptide under several well-defined conditions. The influences of pH, temper

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eed4f758b657f9c6815bc2b818704d82
https://doi.org/10.1006/abio.1995.1289

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Reversed-Phase High-Performance Liquid Chromatography and Capillary Electrophoresis in the Stability Study of the Neuropeptide Growth Factor Antagonist [Arg6,D-Trp7,9,MePhe8]-Substance P {6-11}: A Comparative Study

Autor: W.J.M. Underberg, A. Bult, Jos H. Beijnen, Joop C. M. Waterval, J.L.E. Reubsaet, Jan Teeuwsen, E.H.M. Koster

Publikováno v: Analytical Biochemistry. 220:98-102

Reversed-phase high-performance liquid chromatography and capillary zone electrophoresis are widely used in protein and peptide analysis. Degradation of the basic peptide [Arg 6 , D-Trp 7,9 , MePhe 8 ]-substance P {6-11} (antagonist G) was monitored

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::537dac5cb8c5d5ad1bdcd41241fa155f
https://doi.org/10.1006/abio.1994.1304

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Degradation kinetics of 7-N-(p-hydroxyphenyl)mitomycin C (M-83) in aqueous solution in the presence of γ-cyclodextrin

Autor: Auke Bult, O.A.G.J. van der Houwen, Jan Teeuwsen, Jos H. Beijnen, Otto Bekers, Willy J. M. Underberg

Publikováno v: International Journal of Pharmaceutics. 105:249-254

The degradation kinetics of 7- N -( p -hydroxyphenyl)mitomycin C in the presence of cyclodextrin have been investigated over the pH region 0.3–11. Degradation mixtures were analysed by means of UV-Vis spectrometry and high-performance liquid chroma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d6428b52fca564b6b1bf0f6a28e61807
https://doi.org/10.1016/0378-5173(94)90109-0

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High-performance liquid chromatographic determination of amantadine in urine after micelle-mediated pre-column derivatization with 1-fluoro-2,4-dinitrobenzene

Autor: U.A.Th. Brinkman, J.J.M. Holthuis, F.A.L. Van Der Horst, Jan Teeuwsen

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 8:799-804

Cationic micelles have been used for the derivatization of the anti-Parkinson drug amantadine with the chromophore 1-fluoro-2,4-dinitrobenzene in urine. In the presence of 90 mM cetyltrimethylammonium bromide (CTAB), the conversion of amantadine into

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::158c074ea4ae4a7673fc34047d547555
https://doi.org/10.1016/0731-7085(90)80124-8

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