Zobrazeno 1 - 10
of 441
pro vyhledávání: '"Jan Tavernier"'
Autor:
Willem Daneels, Alexander Van Parys, Leander Huyghe, Elke Rogge, Steffi De Rouck, Ruben Christiaen, Lennart Zabeau, Sylvie Taveirne, Jo Van Dorpe, Niko Kley, Anje Cauwels, Erik Depla, Jan Tavernier, Fritz Offner
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-20 (2024)
Abstract Type I interferon (IFN) is a potent antitumoral drug, with an important history in the treatment of hematologic malignancies. However, its pleiotropic nature leads to severe dose-limiting toxicities that blunt its therapeutic potential. To a
Externí odkaz:
https://doaj.org/article/c7a5f686a979439ab7a58e3892219770
Autor:
Sofie J. Desmet, Jonathan Thommis, Tineke Vanderhaeghen, Edmee M.F. Vandenboorn, Dorien Clarisse, Yunkun Li, Steven Timmermans, Daria Fijalkowska, Dariusz Ratman, Evelien Van Hamme, Lode De Cauwer, Bart Staels, Luc Brunsveld, Frank Peelman, Claude Libert, Jan Tavernier, Karolien De Bosscher
Publikováno v:
Molecular Metabolism, Vol 84, Iss , Pp 101938- (2024)
Objective: The peroxisome proliferator-activated receptor α (PPARα) is a transcription factor driving target genes involved in fatty acid β-oxidation. To what extent various PPARα interacting proteins may assist its function as a transcription fa
Externí odkaz:
https://doaj.org/article/1e23832839bc4f67a6376a644117993b
Autor:
Sandra Van Lint, Alexander Van Parys, Bram Van Den Eeckhout, Niels Vandamme, Stephane Plaisance, Annick Verhee, Dominiek Catteeuw, Elke Rogge, Jennifer De Geest, Nele Vanderroost, Jana Roels, Yvan Saeys, Gilles Uzé, Niko Kley, Anje Cauwels, Jan Tavernier
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-21 (2023)
Abstract Despite major improvements in immunotherapeutic strategies, the immunosuppressive tumor microenvironment remains a major obstacle for the induction of efficient antitumor responses. In this study, we show that local delivery of a bispecific
Externí odkaz:
https://doaj.org/article/72e457857a534bb8861f2b6b4e37b51c
Autor:
Hong-Wen Tang, Kerstin Spirohn, Yanhui Hu, Tong Hao, István A. Kovács, Yue Gao, Richard Binari, Donghui Yang-Zhou, Kenneth H. Wan, Joel S. Bader, Dawit Balcha, Wenting Bian, Benjamin W. Booth, Atina G. Coté, Steffi de Rouck, Alice Desbuleux, Kah Yong Goh, Dae-Kyum Kim, Jennifer J. Knapp, Wen Xing Lee, Irma Lemmens, Cathleen Li, Mian Li, Roujia Li, Hyobin Julianne Lim, Yifang Liu, Katja Luck, Dylan Markey, Carl Pollis, Sudharshan Rangarajan, Jonathan Rodiger, Sadie Schlabach, Yun Shen, Dayag Sheykhkarimli, Bridget TeeKing, Frederick P. Roth, Jan Tavernier, Michael A. Calderwood, David E. Hill, Susan E. Celniker, Marc Vidal, Norbert Perrimon, Stephanie E. Mohr
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Generating reference maps of interactome networks illuminates genetic studies by providing a protein-centric approach to finding new components of existing pathways, complexes, and processes. We apply state-of-the-art methods to identify bin
Externí odkaz:
https://doaj.org/article/e41758225ff34dd59dda7af0132321d4
Autor:
Laura Corneillie, Irma Lemmens, Karin Weening, Amse De Meyer, Freya Van Houtte, Jan Tavernier, Philip Meuleman
Publikováno v:
Viruses, Vol 15, Iss 12, p 2412 (2023)
Throughout their life cycle, viruses interact with cellular host factors, thereby influencing propagation, host range, cell tropism and pathogenesis. The hepatitis E virus (HEV) is an underestimated RNA virus in which knowledge of the virus–host in
Externí odkaz:
https://doaj.org/article/23e11388b4bb41cb8d0c3e7a62c97abd
Autor:
Frederik Paulussen, Chetan P. Kulkarni, Frank Stolz, Eveline Lescrinier, Stijn De Graeve, Suzan Lambin, Arnaud Marchand, Patrick Chaltin, Peter In't Veld, Joseph Mebis, Jan Tavernier, Patrick Van Dijck, Walter Luyten, Johan M. Thevelein
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2023)
The presence of sugar in the gut causes induction of SGLT1, the sodium/glucose cotransporter in intestinal epithelial cells (enterocytes), and this is accompanied by stimulation of sugar absorption. Sugar sensing was suggested to involve a G-protein
Externí odkaz:
https://doaj.org/article/4ae53f76b62b4a54b8ca432078659319
Autor:
Anje Cauwels, Sandra Van Lint, Elke Rogge, Annick Verhee, Bram Van Den Eeckhout, Shengru Pang, Marco Prinz, Niko Kley, Gilles Uzé, Jan Tavernier
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Type I Interferon (IFN) was the very first drug approved for the treatment of Multiple Sclerosis (MS), and is still frequently used as a first line therapy. However, systemic IFN also causes considerable side effects, affecting therapy adher
Externí odkaz:
https://doaj.org/article/2d42a731cebf4e52a6429aa1ceb3e0ed
Autor:
Roser Corominas, Xinping Yang, Guan Ning Lin, Shuli Kang, Yun Shen, Lila Ghamsari, Martin Broly, Maria Rodriguez, Stanley Tam, Shelly A. Wanamaker, Changyu Fan, Song Yi, Murat Tasan, Irma Lemmens, Xingyan Kuang, Nan Zhao, Dheeraj Malhotra, Jacob J. Michaelson, Vladimir Vacic, Michael A. Calderwood, Frederick P. Roth, Jan Tavernier, Steve Horvath, Kourosh Salehi-Ashtiani, Dmitry Korkin, Jonathan Sebat, David E. Hill, Tong Hao, Marc Vidal, Lilia M. Iakoucheva
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/edb05198b36e4cc985f08dabf9c3560d
Autor:
Karen Rosier, Molly T. McDevitt, Joél Smet, Brendan J. Floyd, Maxime Verschoore, Maria J. Marcaida, Craig A. Bingman, Irma Lemmens, Matteo Dal Peraro, Jan Tavernier, Benjamin F. Cravatt, Natalia V. Gounko, Katlijn Vints, Yenthe Monnens, Kritika Bhalla, Laetitia Aerts, Edrees H. Rashan, Arnaud V. Vanlander, Rudy Van Coster, Luc Régal, David J. Pagliarini, John W.M. Creemers
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103460- (2021)
Summary: Deficiency of the serine hydrolase prolyl endopeptidase-like (PREPL) causes a recessive metabolic disorder characterized by neonatal hypotonia, feeding difficulties, and growth hormone deficiency. The pathophysiology of PREPL deficiency and
Externí odkaz:
https://doaj.org/article/a2916c2ecc194c18bb66fc5774a5e60f
Autor:
Bram Van Den Eeckhout, Leander Huyghe, Sandra Van Lint, Elianne Burg, Stéphane Plaisance, Frank Peelman, Anje Cauwels, Gilles Uzé, Niko Kley, Sarah Gerlo, Jan Tavernier
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 11 (2021)
Externí odkaz:
https://doaj.org/article/d36241b88658437b966c5cf4b40f4553