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Molecular Modification of Anpirtoline, a Non-Opioid Centrally Acting Analgesic

Autor: Wieland Hafner, Petr Hezký, Ivan Krejci, Jan Proška, Stanislav Radl, Jan Taimr

Publikováno v: Scopus-Elsevier

Molecular modification of anpirtoline (2a) is described. Several methods of preparation of 4-[(3-chlorophenyl)sulfanyl]-1-methylpiperidine (3a) and its demethylation led to the deazaanpirtoline (3c). Nucleophilic substitution of piperidine-4-thiole w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0761e707645b520d72a1aa61f40d899e
https://doi.org/10.1135/cccc19990363

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Revised structure of isoschizogamine

Autor: Josef Hajicek, Jan Taimr, Miloš Buděšínský

Publikováno v: Tetrahedron Letters. 39:505-508

Isoschizogamine was isolated from the twigs of Schizozygia caffaeoides and its structure revised to 10 on the basis of NMR analysis. It is shown to possess as yet undescribed hexacyclic skeleton of N-acyl 1,2,3,4-tetrahydroquinoline type, the nitroge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b1e220a29af52bfc95e1ed40fb65d93b
https://doi.org/10.1016/s0040-4039(97)10588-3

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Chiral Forms of 4-(2',4'-Difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic Acid (Flobufen) and Its Metabolite.Synthesis and Basic Biological Properties

Autor: Hana Zůnová, Miroslav Kuchař, Hana Tomková, Alexandr Jegorov, Antonín Jandera, Marie Poppová, Jan Taimr, Vladimíra Panajotovová, Miloš Buděšínský

Publikováno v: Collection of Czechoslovak Chemical Communications. 62:498-509

4-(2',4'-Difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acid (1, flobufen) is subjected to clinical testing in the treatment of rheumatoid arthritis. Owing to the occurrence of a centre of chirality, the compound exists in two enantiomers, and its maj

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e9eed9b3d6672ced17875266152f62c
https://doi.org/10.1135/cccc19970498

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Cyclic Dipeptides with 1-Aminocyclopropane-1-carboxylic Acid

Autor: Jarmila Vinšová, Antonin Sturc, Jan Taimr, E. Kasafirek, Jaroslav Moural

Publikováno v: Scopus-Elsevier

Cyclic dipeptides of the formula cyclo(-Acc-X-), where Acc = 1-aminocyclopropane-1-carboxylic acid, X = Gly, Ala, Val, Leu, Phe or Tyr, were synthesized. The prepared 2,5-piperazinediones showed no proliferative or antiproliferative activity on norma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ed582c24865f0e9e63ecfa3feb5af7e
https://doi.org/10.1135/cccc19970941

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Some Analogs of 4-(2',4'-Difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic Acid: Synthesis and Antiinflammatory Activity

Autor: Hana Tomková, Marie Poppová, Eva Knězová, Václav Vosátka, Vladimíra Panajotovová, Jan Taimr, Miroslav Kuchař

Publikováno v: Collection of Czechoslovak Chemical Communications. 60:1026-1033

Analogs of 4-(2',4'-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acid (I, flobufen), containing a double bond (II, IV, V, VII, VIII) or a methyl group in position 3 (VI) were prepared. Their antiinflammatory activity was evaluated and compared with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::790866a257c80133448a5736beac325e
https://doi.org/10.1135/cccc19951026

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Potential Nootropic Agents: Synthesis of Some 1,4-Disubstituted 2-Oxopyrrolidines and Some Related Compounds

Autor: Jiří Urban, Vladimír Valenta, Zdeněk Polívka, Jan Taimr

Publikováno v: Collection of Czechoslovak Chemical Communications. 59:1126-1136

4-(Aminomethyl)-1-benzyl-2-oxopyrrolidine (VI) was transformed by treatment with (4-benzhydrylpiperazin-1-yl)carbonyl chlorides IIIb - IIId and with (4-methylpiperazin-1-yl)carbonyl chloride (IIIa) to the carboxamides IVa - IVd. Heating of 1-(ethoxyc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::023589da04d52795e07b1e81ff70c2d7
https://doi.org/10.1135/cccc19941126

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