Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jan Svadlenka"'
Publikováno v:
Biochemistry and Biophysics Reports, Vol 5, Iss C, Pp 246-252 (2016)
Multifunctional adapter and chaperone protein Daxx participates in the regulation of a number of mainly transcription-related processes. Most notably in a complex with chromatin-remodelling ATPase ATRX, Daxx serves as a histone H3.3 chaperone at telo
Externí odkaz:
https://doaj.org/article/5f41b3fe813d4cb7bf09983fd1be254a
Autor:
Pavel Klener, Marek Trneny, Robert Pytlik, Roman Kodet, Mahmudul Alam, Bokang Calvin Lenyeletse Maswabi, Jan Molinsky, Lucie Lateckova, Petra Vockova, Karel Helman, Radek Jaksa, Dana Vejmelkova, Dana Prukova, Jan Soukup, Simona Benesova, Jan Svadlenka, Jan Brazina, Ladislav Andera, Magdalena Klanova
Western blot analysis showing protein expression profile of key regulators of apoptosis in 18 DLBCL cell lines (12 germinal center B-cell-like (GCB) and 6 activated B-cell-like (ABC) DLBCL cell lines). *UPF4D cell line (GCB origin) was derived in our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c173972cf2e268702b74b82a1e49d1e3
https://doi.org/10.1158/1078-0432.22457130
https://doi.org/10.1158/1078-0432.22457130
Autor:
Pavel Klener, Marek Trneny, Robert Pytlik, Roman Kodet, Mahmudul Alam, Bokang Calvin Lenyeletse Maswabi, Jan Molinsky, Lucie Lateckova, Petra Vockova, Karel Helman, Radek Jaksa, Dana Vejmelkova, Dana Prukova, Jan Soukup, Simona Benesova, Jan Svadlenka, Jan Brazina, Ladislav Andera, Magdalena Klanova
Purpose: To investigate the roles of BCL2, MCL1, and BCL-XL in the survival of diffuse large B-cell lymphoma (DLBCL).Experimental designs: Immunohistochemical analysis of 105 primary DLBCL samples, and Western blot analysis of 18 DLBCL cell lines for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f7657670078fc56e9d1f3aa2eb5276
https://doi.org/10.1158/1078-0432.c.6523509.v1
https://doi.org/10.1158/1078-0432.c.6523509.v1
Autor:
Pavel Klener, Marek Trneny, Robert Pytlik, Roman Kodet, Mahmudul Alam, Bokang Calvin Lenyeletse Maswabi, Jan Molinsky, Lucie Lateckova, Petra Vockova, Karel Helman, Radek Jaksa, Dana Vejmelkova, Dana Prukova, Jan Soukup, Simona Benesova, Jan Svadlenka, Jan Brazina, Ladislav Andera, Magdalena Klanova
Shown are examples of different levels of semi-quantitative protein expression (0-3).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d072966c6995f80fa38e44a6170501a
https://doi.org/10.1158/1078-0432.22457133
https://doi.org/10.1158/1078-0432.22457133
Autor:
Pavel Klener, Marek Trneny, Robert Pytlik, Roman Kodet, Mahmudul Alam, Bokang Calvin Lenyeletse Maswabi, Jan Molinsky, Lucie Lateckova, Petra Vockova, Karel Helman, Radek Jaksa, Dana Vejmelkova, Dana Prukova, Jan Soukup, Simona Benesova, Jan Svadlenka, Jan Brazina, Ladislav Andera, Magdalena Klanova
To investigate whether the expression level of BCL2 proteins detected by western blot is comparable with the expression level assessed by IHC analysis, we analyzed protein expression (by IHC) of BCL2, MCL1 and BCL-XL from subcutaneous lymphoma xenogr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63969706514c34ab22db984109d7a24f
https://doi.org/10.1158/1078-0432.22457115.v1
https://doi.org/10.1158/1078-0432.22457115.v1
Autor:
Pavel Klener, Marek Trneny, Robert Pytlik, Roman Kodet, Mahmudul Alam, Bokang Calvin Lenyeletse Maswabi, Jan Molinsky, Lucie Lateckova, Petra Vockova, Karel Helman, Radek Jaksa, Dana Vejmelkova, Dana Prukova, Jan Soukup, Simona Benesova, Jan Svadlenka, Jan Brazina, Ladislav Andera, Magdalena Klanova
(A) Comparison of the extent of apopotosis induced by HHT (after 24hrs exposure) in HHT-resistant (HHT-R) clones compared to the original cell lines (CTRL). (B) Western blot analysis demonstrates upregulation of BCL-XL protein in HHT-R clones compare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::883706f3111a5507d671c92a8ec2bf45
https://doi.org/10.1158/1078-0432.22457118
https://doi.org/10.1158/1078-0432.22457118
Autor:
Pavel Klener, Marek Trneny, Robert Pytlik, Roman Kodet, Mahmudul Alam, Bokang Calvin Lenyeletse Maswabi, Jan Molinsky, Lucie Lateckova, Petra Vockova, Karel Helman, Radek Jaksa, Dana Vejmelkova, Dana Prukova, Jan Soukup, Simona Benesova, Jan Svadlenka, Jan Brazina, Ladislav Andera, Magdalena Klanova
The graphs show the extent of apoptosis of DLBCL cell lines induced by different concentrations of HHT, ABT-199 and ABT-737 after 24hrs exposure to particular agents.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a5e50a0a51e72b6007cddc684aa7ff2
https://doi.org/10.1158/1078-0432.22457124.v1
https://doi.org/10.1158/1078-0432.22457124.v1
Autor:
Pavel Klener, Marek Trneny, Robert Pytlik, Roman Kodet, Mahmudul Alam, Bokang Calvin Lenyeletse Maswabi, Jan Molinsky, Lucie Lateckova, Petra Vockova, Karel Helman, Radek Jaksa, Dana Vejmelkova, Dana Prukova, Jan Soukup, Simona Benesova, Jan Svadlenka, Jan Brazina, Ladislav Andera, Magdalena Klanova
Cell of origin (COO), BCL2 expression status and IC100 for ABT-199 (µM) and HHT (nM) are shown.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1397d4117a0aff828cfc6dc72b61ae48
https://doi.org/10.1158/1078-0432.22457112.v1
https://doi.org/10.1158/1078-0432.22457112.v1
Publikováno v:
Biochemistry and Biophysics Reports
Biochemistry and Biophysics Reports, Vol 5, Iss C, Pp 246-252 (2016)
Biochemistry and Biophysics Reports, Vol 5, Iss C, Pp 246-252 (2016)
Multifunctional adapter and chaperone protein Daxx participates in the regulation of a number of mainly transcription-related processes. Most notably in a complex with chromatin-remodelling ATPase ATRX, Daxx serves as a histone H3.3 chaperone at telo
Autor:
Simona Benesova, Ladislav Andera, Jiri Neuzil, Marie Ksandrova, Zuzana Nahacka, Martin Peterka, Jan Svadlenka
Publikováno v:
Biochimica et biophysica acta. Molecular cell research. 1865(3)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a cytokine that can trigger apoptosis in many types of human cancer cells via engagement of its two pro-apoptotic receptors TRAIL-R1 (DR4) and TRAIL-R2 (DR5). TRAIL can also activate