Association of NQO2 With UDP-Glucuronosyltransferases Reduces Menadione Toxicity in Neuroblastoma Cells

Autor: Monivan Chhour, Pierre Perio, Regis Gayon, Hélène Ternet-Fontebasso, Gilles Ferry, Françoise Nepveu, Jean A. Boutin, Jan Sudor, Karine Reybier

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)

The balance between detoxification and toxicity is linked to enzymes of the drug metabolism Phase I (cytochrome P450 or oxidoreductases) and phase II conjugating enzymes (such as the UGTs). After the reduction of quinones, the product of the reaction

Externí odkaz: https://doaj.org/article/26bc792e0c0542f4b230c4e3914b1c67

Synthesis of 6-Amino-5-cyano-1,4-disubstituted-2(1H)-Pyrimidinones via Copper-(I)-catalyzed Alkyne-azide ‘Click Chemistry’ and Their Reactivity

Autor: Fethi Zribi, Romain Duval, Fakher Chabchoub, Françoise Nepveu, Ennaji Najahi, Jan Sudor

Publikováno v: Molecules, Vol 15, Iss 12, Pp 8841-8855 (2010)

In this paper we present the room temperature synthesis of a novel serie of 1,4-disubstituted-1,2,3-triazoles 4a-l by employing the (3 + 2) cycloaddition reaction of pyrimidinones containing alkyne functions with different model azides in the presenc

Externí odkaz: https://doaj.org/article/b21500e3bf604470b7ab65484bc18760

Legume Lectins with Different Specificities as Potential Glycan Probes for Pathogenic Enveloped Viruses

Autor: Annick Barre, Els J. M. Van Damme, Bernard Klonjkowski, Mathias Simplicien, Jan Sudor, Hervé Benoist, Pierre Rougé

Publikováno v: CELLS
Cells, Vol 11, Iss 339, p 339 (2022)

Pathogenic enveloped viruses are covered with a glycan shield that provides a dual function: the glycan structures contribute to virus protection as well as host cell recognition. The three classical types of N-glycans, in particular complex glycans,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a266def89d2b9b2d7f0743d08c8348
https://pubmed.ncbi.nlm.nih.gov/35159151

Oxidative stress and neurodegeneration: The possible contribution of quinone reductase 2

Autor: Françoise Nepveu, Karine Reybier, Jan Sudor, Laure-Estelle Cassagnes, Monivan Chhour, Régis Gayon, Pierre Perio, Jean A. Boutin, Gilles Ferry

Publikováno v: Free Radical Biology and Medicine
Free Radical Biology and Medicine, Elsevier, 2018, 120, pp.56-61. ⟨10.1016/j.freeradbiomed.2018.03.002⟩
Free Radical Biology and Medicine, 2018, 120, pp.56-61. ⟨10.1016/j.freeradbiomed.2018.03.002⟩

International audience; There is increasing evidence that oxidative stress is involved in the etiology and pathogenesis of neurodegenerative disorders. Overproduction of reactive oxygen species (ROS) is due in part to the reactivity of catecholamines

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::883ba737d694b3d84bf3f9793faf9536
https://pubmed.ncbi.nlm.nih.gov/29526807

Thermally Induced Gelation of Poly(acrylamide) Grafted with Poly(N-isopropylacrylamide): A Small-Angle Neutron Scattering Study

Autor: Annie Brulet, Valessa Barbier, Dominique Hourdet, Jean-Louis Viovy, Jan Sudor, Mélanie Herve

Publikováno v: Macromolecules. 37:5682-5691

Sieving matrixes of poly(acrylamide) grafted with poly(N-isopropylacrylamide) (PNIPAM) were developed in the framework of DNA sequencing by capillary electrophoresis. As a result of their thermodynamic properties, PNIPAM side chains self-aggregate ab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a6049374c276be976e3ce9318a6dac68
https://doi.org/10.1021/ma049182y