Výsledky vyhledávání

Akademický článek

NDRG1 acts as an oncogene in triple-negative breast cancer and its loss sensitizes cells to mitochondrial iron chelation

Autor: Sukanya B. Jadhav, Michaela Vondrackova, Petra Potomova, Cristian Sandoval-Acuña, Jana Smigova, Kristyna Klanicova, Daniel Rosel, Jan Brabek, Jan Stursa, Lukas Werner, Jaroslav Truksa

Publikováno v: Frontiers in Pharmacology, Vol 15 (2024)

Multiple studies indicate that iron chelators enhance their anti-cancer properties by inducing NDRG1, a known tumor and metastasis suppressor. However, the exact role of NDRG1 remains controversial, as newer studies have shown that NDRG1 can also act

Externí odkaz: https://doaj.org/article/babf7f9ee7ce45d2aa4ee3ab2d7ec896

Zobrazit plný text záznamu

Akademický článek

Mitochondrially targeted tamoxifen as anticancer therapy: case series of patients with renal cell carcinoma treated in a phase I/Ib clinical trial

Autor: Zuzana Bielcikova, Lukas Werner, Jan Stursa, Vladimir Cerny, Ludmila Krizova, Jan Spacek, Stanislav Hlousek, Michal Vocka, Olga Bartosova, Michal Pesta, Katarina Kolostova, Petr Klezl, Vladimir Bobek, Jaroslav Truksa, Sona Stemberkova-Hubackova, Lubos Petruzelka, Pavel Michalek, Jiri Neuzil

Publikováno v: Therapeutic Advances in Medical Oncology, Vol 15 (2023)

Mitochondrially targeted anticancer drugs (mitocans) that disrupt the energy-producing systems of cancer are emerging as new potential therapeutics. Mitochondrially targeted tamoxifen (MitoTam), an inhibitor of mitochondrial respiration respiratory c

Externí odkaz: https://doaj.org/article/269f239884f64e4ea206c5d48ff311b3

Zobrazit plný text záznamu

Akademický článek

Mitochondrially targeted tamoxifen in patients with metastatic solid tumours: an open-label, phase I/Ib single-centre trialResearch in context

Publikováno v: EClinicalMedicine, Vol 57, Iss , Pp 101873- (2023)

Summary: Background: Mitochondria present an emerging target for cancer treatment. We have investigated the effect of mitochondrially targeted tamoxifen (MitoTam), a first-in-class anti-cancer agent, in patients with solid metastatic tumours. Methods

Externí odkaz: https://doaj.org/article/91ab15755d5b4f4c9326f015bc30ba5c

Zobrazit plný text záznamu

Akademický článek

Mitochondrially targeted tamoxifen alleviates markers of obesity and type 2 diabetes mellitus in mice

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

Senescent cells play a role in pathogenesis of diabetes, and senolytic agents can improve obesity- and diabetes-related pathologies. Here the authors report that mitochondrially targeted tamoxifen, a potential anti-cancer agent with senolytic activit

Externí odkaz: https://doaj.org/article/e1a97d3a7b444e588a78bce984149ca2

Zobrazit plný text záznamu

Akademický článek

Extremely rapid isotropic irradiation of nanoparticles with ions generated in situ by a nuclear reaction

Autor: Jan Havlik, Vladimira Petrakova, Jan Kucka, Helena Raabova, Dalibor Panek, Vaclav Stepan, Zuzana Zlamalova Cilova, Philipp Reineck, Jan Stursa, Jan Kucera, Martin Hruby, Petr Cigler

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)

Mass production of nanoparticles containing well-controlled structural defects is a challenge. Here the authors demonstrate the feasibility of homogeneous ion irradiation generated in a nuclear reactor, for the preparation of fluorescent nanodiamonds

Externí odkaz: https://doaj.org/article/d24191b157dd408483a7995aee04b7c0

Zobrazit plný text záznamu

Akademický článek

Characterisation of mesothelioma-initiating cells and their susceptibility to anti-cancer agents.

Autor: Elham Alizadeh Pasdar, Michael Smits, Michael Stapelberg, Martina Bajzikova, Marina Stantic, Jacob Goodwin, Bing Yan, Jan Stursa, Jaromira Kovarova, Karishma Sachaphibulkij, Ayenachew Bezawork-Geleta, Margaryta Sobol, Anatoly Filimonenko, Marco Tomasetti, Renata Zobalova, Pavel Hozak, Lan-Feng Dong, Jiri Neuzil

Publikováno v: PLoS ONE, Vol 10, Iss 5, p e0119549 (2015)

Malignant mesothelioma (MM) is an aggressive type of tumour causing high mortality. One reason for this paradigm may be the existence of a subpopulation of tumour-initiating cells (TICs) that endow MM with drug resistance and recurrence. The objectiv

Externí odkaz: https://doaj.org/article/a785e430df50486c96bc071f5315b30c

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání